Competitive molecular interaction among paeonol-loaded liposomes: Differential scanning calorimetry and synchrotron X-ray diffraction studies

Wu, Rui-Guang; Dai, Jundong; Wu, Fugen; Zhang, Xiaohua; Li, Weifeng; Wang, Yurong

doi:10.1016/j.ijpharm.2012.08.052

Cited by 33 publications

(23 citation statements)

References 39 publications

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“…U svim uzorcima nakon procesa sprej sušenja vrednosti promene entalpije bile su veće nego nakon liofilizacije, osim kod čistog ekstrakta. Generalno, visoke vrednosti promene entalpije ukazuju na prisustvo stabilizirajućih interakcija između inkapsuliranih komponenata i nosača [23].…”

Section: Slika 6 -Sem Analiza žElatinskih Inkapsulata Ekstrakta Majčiunclassified

Gelatin as a carrier system for delivery of polyphenols compounds

Jovanović¹,

Djordjević²,

Lević³

et al. 2017

Tehnika

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Section: Slika 6 -Sem Analiza žElatinskih Inkapsulata Ekstrakta Majčiunclassified

Gelatin as a carrier system for delivery of polyphenols compounds

Jovanović¹,

Djordjević²,

Lević³

et al. 2017

Tehnika

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“…Pae-loaded liposomes were successfully constructed by Wu et al, but there was no further antitumor evaluation. 15 Previous studies have shown that, when used as a sustained drug delivery system, drug-loaded nanoparticles can effectively accumulate in tumor cells by endocytosis, and at the tumor site through the enhanced permeability and retention effect. 3,16 In this study, methoxy PEG-PCL (mPEG-PCL) nanoparticles were adopted as drug carriers to prepare Pae-loaded nanoparticles (Pae-NPs).…”

Section: Introductionmentioning

confidence: 99%

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects

Chen¹,

Feng²,

Hou³

et al. 2017

IJN

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Paeonol (Pae; 2′-hydroxy-4′-methoxyacetophenone) has attracted intense attention as a potential therapeutic agent against various cancers. However, the use of Pae is limited owing to its hydrophobicity. Recently, biodegradable polymeric nanoparticles with amphiphilic copolymers have been used as drug carriers; these have better bioavailability and are promising tumor-targeted drug delivery systems. In the current study, we prepared Pae-loaded nanoparticles (Pae-NPs) with amphiphilic block copolymers using nanoprecipitation. The physiochemical characteristics and antitumor effects of nanoparticles were evaluated in different cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays showed substantial inhibition of cell growth by Pae-NPs. Moreover, lower doses of Pae-NPs inhibited cell growth more efficiently than the equivalent doses of free Pae. Inhibition was characterized by significant elevation of intracellular reactive oxygen species and subsequent inhibition of Akt and regulation of apoptotic proteins, which could be partly reversed by pretreatment with the antioxidant N-acetylcysteine. In vivo results also demonstrated that Pae-NPs could exert much stronger antitumor effects than free Pae. Therefore, Pae-NPs represent a promising delivery system to overcome the low solubility of Pae and enable its use in treating cancer.

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“…Paeonol (see Fig. 1) is the major active ingredient of the root cortex Moutan peony (Chinese name: Mudan, which is the national flower of China) [24,31,32]. Numerous pharmacological studies showed that paeonol is a volatile compound with analgesic, antipyretic, sedative, anti-inflammatory, anti-oxidative, and antibacterial properties [7,13,[31][32][33].…”

Section: Introductionmentioning

confidence: 99%

“…As a major component of lecithins (L-α-phosphatidylcholines), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, as shown in Fig. 1) has often been chosen to prepare liposomes both because lecithins are the major components in mammalian membranes and also because they show a sharp, strong, thermotropic transition near the physiological temperature [5,11,26,27,31,32]. Cholesterol (as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

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Structural properties of paeonol encapsulated liposomes at physiological temperature: Synchrotron small-angle and wide-angle X-ray diffraction studies

Sun

Zhao

et al. 2016

BSI

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Abstract. Structural properties of paeonol-encapsulated liposomes containing cholesterol or stigmasterol at 37°C have been investigated by synchrotron small-angle X-ray scattering (SAXS) and wide-angle X-ray scattering (WAXS) techniques. We compared the structural properties of pure dipalmitoylphosphatidylcholine (DPPC) liposomes, sterol-DPPC liposomes, and those of paeonol-sterol-DPPC liposomes at different molar ratios. Three conclusions can be drawn: First, phase separation occurs in both sterol-DPPC and paeonol-sterol-DPPC liposomes. Second, the incorporation of paeonol molecules into sterol-DPPC liposomes weakens the membrane order. Third, cholesterol has a stronger tendency to interact with DPPC as compared to its counterpart in plant, stigmasterol.

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Competitive molecular interaction among paeonol-loaded liposomes: Differential scanning calorimetry and synchrotron X-ray diffraction studies

Cited by 33 publications

References 39 publications

Gelatin as a carrier system for delivery of polyphenols compounds

Gelatin as a carrier system for delivery of polyphenols compounds

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects

Structural properties of paeonol encapsulated liposomes at physiological temperature: Synchrotron small-angle and wide-angle X-ray diffraction studies

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