Compilation of Conversion Coefficients for the Dose to the Lens of the Eye

Behrens, R.

doi:10.1093/rpd/ncw194

Cited by 14 publications

(22 citation statements)

References 9 publications

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“…One observes very good agreement between the different sets of coefficients with the exception of 36 Cl, where the dose rate calculated with the 2017 coefficients from Behrens is 25% higher than the value obtained with the 2011 coefficients from the same author. In the 2017 compilation, Behrens gave the maximum coefficients of the left and right eye lens for the realistic eye model inserted in a phantom (Behrens 2017a), while in the 2010 paper, the coefficients had been calculated in an isolated eye (Behrens et al 2010). Hence, the 2017 coefficients for electrons at energies under 700 keV, where most of the 36 Cl beta emission is found, were larger than those of the 2010 paper.…”

Section: Resultsmentioning

confidence: 98%

“…Later, in 2017, Behrens produced an extensive compilation of photon, electron and positron dose coefficients (Behrens 2017a). In particular, this compilation provides photon coefficients for all combinations of the following parameters:…”

Section: Photon Coefficientsmentioning

confidence: 99%

“…but this time for the realistic eye model inserted in a whole-body phantom, and by exposing the head and the trunk to the incident electrons (Behrens 2012b). Behrens also included dose coefficients for electrons and positrons in his major compilation (Behrens 2017a), and those values were also largely adopted by the ICRP. They are found in its publication 116 (ICRP 2010).…”

Section: Photon Coefficientsmentioning

confidence: 99%

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A New Software for the Calculation of Eye-lens Dosimetry Quantities Based on Dose-rate Coefficients

Dubeau,

Sun

2023

Health Physics

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In the last decade, the International Commission on Radiological Protection recommended a reduction in the annual limits to the dose to the lens of the eye from 150 mSv to 20 mSv y−1, averaged over defined periods of 5 y, with no single year exceeding 50 mSv. To assist the health physics community in this task, many groups have calculated protection and operational fluence dose coefficients. This led to the publication of multiple coefficient tables that were calculated for arrays of different parameters, including particle type, angle of incidence, target phantom models, presence or absence of secondary charged particle equilibrium, etc. The coefficients available in the literature include protection dose values calculated in a realistic eye model and operational values calculated in a simplified cylindrical head phantom at a point 3 mm below the surface. This paper reports on a simple Windows™ application that was written to aid health physics professionals in accessing and using the large body of available protection and operational eye-lens data. The application is called the Eye-Lens Dose Calculator, as it also performs calculations of the eye-lens dose for radionuclides, where the complete emissions of the selected radionuclides are considered. Test cases show that there is good agreement between the calculated protection and operational dose quantities when radionuclide emission characteristics are considered.

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Section: Resultsmentioning

confidence: 98%

Section: Photon Coefficientsmentioning

confidence: 99%

Section: Photon Coefficientsmentioning

confidence: 99%

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A New Software for the Calculation of Eye-lens Dosimetry Quantities Based on Dose-rate Coefficients

Dubeau,

Sun

2023

Health Physics

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“…About the eye geometry implemented into the model, we referred to the classical works by Bherens 18 , 19 and El Basha 20 that can be considered the state of the art: the resulting geometry has been described in Fig. 2 c. The material’s characteristics (Tables 1 , 3 ), properly tuned for a Monte Carlo transport simulation, have been set accordingly to the above cited references.…”

Section: Methodsmentioning

confidence: 99%

DNA damage in lens epithelial cells exposed to occupationally-relevant X-ray doses and role in cataract formation

Udroiu

Sgura

Chendi

et al. 2020

Sci Rep

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The current framework of radiological protection of occupational exposed medical workers reduced the eye-lens equivalent dose limit from 150 to 20 mSv per year requiring an accurate dosimetric evaluation and an increase understanding of radiation induced effects on Lens cells considering the typical scenario of occupational exposed medical operators. Indeed, it is widely accepted that genomic damage of Lens epithelial cells (LEC) is a key mechanism of cataractogenesis. However, the relationship between apoptosis and cataractogenesis is still controversial. In this study biological and physical data are combined to improve the understanding of radiation induced effects on LEC. To characterize the occupational exposure of medical workers during angiographic procedures an INNOVA 4100 (General Electric Healthcare) equipment was used (scenario A). Additional experiments were conducted using a research tube (scenario B). For both scenarios, the frequencies of binucleated cells, micronuclei, p21-positive cells were assessed with different doses and dose rates. A Monte-Carlo study was conducted using a model for the photon generation with the X-ray tubes and with the Petri dishes considering the two different scenarios (A and B) to reproduce the experimental conditions and validate the irradiation setups to the cells. The simulation results have been tallied using the Monte Carlo code MCNP6. The spectral characteristics of the different X-ray beams have been estimated. All irradiated samples showed frequencies of micronuclei and p21-positive cells higher than the unirradiated controls. Differences in frequencies increased with the delivered dose measured with Gafchromic films XR-RV3. The spectrum incident on eye lens and Petri, as estimated with MCNP6, was in good agreement in the scenario A (confirming the experimental setup), while the mean energy spectrum was higher in the scenario B. Nevertheless, the response of LEC seemed mainly related to the measured absorbed dose. No effects on viability were detected. Our results support the hypothesis that apoptosis is not responsible for cataract induced by low doses of X-ray (i.e. 25 mGy) while the induction of transient p21 may interfere with the disassembly of the nuclear envelop in differentiating LEC, leading to cataract formation. Further studies are needed to better clarify the relationship we suggested between DNA damage, transient p21 induction and the inability of LEC enucleation.

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“…The dose per energy rapidly increases to this maximum and then slowly decreases after to stagnate around 8.6 Â 10 −12 Sv beta −1 . As photons have been discarded, and therefore annihilation photons do not create secondary electrons in the environment, greater importance of dose from positrons at low energy has not been observed as in other publications (Behrens 2017). Photons have been discarded to avoid taking them into account in the Q B coefficient (IAEA 2012).…”

Section: Methods For Q B Calculationmentioning

confidence: 99%

Spectrum and Yield to Dose Conversion Coefficients for Beta Skin Doses Linked to the Q System

et al. 2019

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Monte Carlo simulations are a state-of-the-art method to calculate dose coefficients and could be used with the Q system for radioactive material packaging. These simulations often take a long time to converge with sufficient precision. Furthermore, if multiple sources have to be taken into account, many weeks of calculations may be needed. In order to reduce the calculation time, this paper proposes a new method based on a transfer function to instantly compute Q values associated with beta skin doses. The method developed in this paper can be applied to compute beta skin dose and easily could be extended to other particles and different depths in organs with various kinds of shielding configurations between source and target.

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Compilation of Conversion Coefficients for the Dose to the Lens of the Eye

Cited by 14 publications

References 9 publications

A New Software for the Calculation of Eye-lens Dosimetry Quantities Based on Dose-rate Coefficients

A New Software for the Calculation of Eye-lens Dosimetry Quantities Based on Dose-rate Coefficients

DNA damage in lens epithelial cells exposed to occupationally-relevant X-ray doses and role in cataract formation

Spectrum and Yield to Dose Conversion Coefficients for Beta Skin Doses Linked to the Q System

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