1978
DOI: 10.1111/j.1365-2133.1978.tb02016.x
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Complement and immunoglobulin deposits in the skin of patients with atopic dermatitis

Abstract: The immunofluorescent patterns of uninvolved and involved skin biopsies from eight patients with atopic dermatitis were studied, using direct immunofluorescence techniques to identify deposits of the immunoglobulins G, A and M as well as the complement factors C1q, C3, C4, C5, factor B and properdin. Immunoglobulin deposits (mainly IgG) were found in five patients, complement deposits in three patients in the basement membrane zone. In three patients the immunofluorescence was positive for C3, in two patients … Show more

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Cited by 35 publications
(18 citation statements)
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“…Itch-mediating receptors are free endings of thin, unmyelinated, slow-conducting C-fibers showing their highest density at the dermal-epidermal junction level [14,15]. In patients with atopic eczema, complement and immunoglobulin deposits near this level of the skin have been found [16]. For a long time, the nature of itch-specific nerve fibers was questioned [14,17]; itch was regarded as a subquality of pain.…”
Section: Pathophysiologymentioning
confidence: 99%
“…Itch-mediating receptors are free endings of thin, unmyelinated, slow-conducting C-fibers showing their highest density at the dermal-epidermal junction level [14,15]. In patients with atopic eczema, complement and immunoglobulin deposits near this level of the skin have been found [16]. For a long time, the nature of itch-specific nerve fibers was questioned [14,17]; itch was regarded as a subquality of pain.…”
Section: Pathophysiologymentioning
confidence: 99%
“…We believe an array (antibody and cell-mediated) of immune re sponses might operate in this group. It is possible to speculate that in this form of CMA an asymptomatic gut mucosal IgE hypersensitivity response and the persistence of dietary antigen might act in synergy to result in the enhanced absorption of antigen [18], en hanced production [22] and local deposition [23] of immune complexes and complement, and the subse quent recruitment of lymphoid cells [24], resulting in cell-mediated damage to the target tissue. Such a series of events could well contribute to the chronic diarrhea and failure to thrive seen in a number of pa tients in this series with gastrointestinal responses and described previously by others [3,25].…”
Section: Discussionmentioning
confidence: 99%
“…The Langerhans' cell number is increased in chronic lichenified plaques to a greater degree than in acute erythematous lesions (10,17).…”
Section: Immunopathologymentioning
confidence: 99%