Complement C3 and C4, but not their regulators or activated products, are associated with incident metabolic syndrome: the CODAM study

Xin, Ying; Hertle, Elisabeth; Kallen, Carla; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Greevenbroek, Marleen M.J. van

doi:10.1007/s12020-018-1712-3

Cited by 19 publications

(22 citation statements)

References 43 publications

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“…A study conducted among people of Caucasian descent above 40 years showed significant associations of C1q with TG, HDL-C, and FPG. As reported in that study, the relationship between C1q and MetS was modest (42), which was inconsistent with our results. This difference may be attributed to the subjects belonging to a specific population of individuals who already exhibit moderately increased risk of cardiometabolic diseases.…”

Section: Discussioncontrasting

confidence: 99%

Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents

Yang

Zhao

et al. 2020

Front. Endocrinol.

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BackgroundComplement C1q (C1q) has been confirmed to be related to obesity, metabolic syndrome (MetS), and its components. However, human data regarding the associations are relatively scarce. This study aimed to investigate associations of C1q with obesity as well as MetS in Chinese adolescents.MethodsA total of 1,191 Chinese adolescents aged 13–18 years were enrolled in this study. The biochemical and anthropometric variables of all the subjects were evaluated using standardized procedures. C1q was measured using the immunoturbidometric assay. The relationship between C1q and obesity or MetS was analyzed using multiple regression analyses.ResultsObesity was more prevalent among participants in the highest tertile than in the lowest tertile of C1q levels. The highest tertile of C1q was related to a greater effect on the risk of MetS, and its trend test was statistically significant. Except for hyperglycemia, the prevalence of other components of MetS significantly increased relative to an increase in C1q tertile. Receiver operating characteristic (ROC) curve analysis of C1q for predicting adolescents with MetS illustrated that the area under the curve (AUC) was 0.82 [95% confidence interval (CI): 0.76, 0.88; P<0.001] in the total population after adjusting for confounders.ConclusionsThis study observed a significantly higher prevalence of obesity and MetS features in adolescents with high C1q. The findings of the current study also reported a significant relationship between C1q levels and MetS components [except for fasting plasma glucose (FPG)] in Chinese adolescents. C1q may represent a biomarker for predicting obesity or MetS in adolescents.

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Section: Discussioncontrasting

confidence: 99%

Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents

Yang

Zhao

et al. 2020

Front. Endocrinol.

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“…Glutamic oxalacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) used to evaluate liver whether injury [35] . Complement system is considered that defense system for resistance against microbial infection, mainly included C3 and C4 [36] . Superoxide dismutase (SOD) can eliminate free radicals, like hydroxyl radicals and superoxide anion radicals, improve antioxidant capacity [37] .…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary soy isoflavone and soy saponin on growth performance, intestinal structure, intestinal immunity and gut microbiota community on rice field eel (Monopterus albus)

et al. 2021

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Background: Soy iso avone and soy saponin are heat-stable glycosides present in soybean meal, which is the major factor restrict soy protein using in aquatic feed. This study is aimed to conduct that dietary soy iso avone and soy saponin on growth performance, intestinal structure, intestinal immunity and gut microbiota community on rice eld eel (Monopterus albus), and revealed its mechanism. Results: In current study, dietary 1g/kg soy iso avone, 2g/kg soy saponin and their mixed feed decreased growth of M. albus. Dietary 1g/kg soy iso avone signi cantly increased serum alkaline phosphatase (P < 0.05), dietary 2g/kg soy saponin remarkably declined intestinal immunoglobulin M (P < 0.05). Dietary 1g/kg soy iso avone and 2g/kg soy saponin mixed feed signi cantly decreased intestinal complement 3, complement 4 and immunoglobulin M, amounts of intestinal goblet cells per root and shannon of gut microbiota (P < 0.05). Dietary 1g/kg soy iso avone, 2g/kg soy saponin and their mixed feed down regulated intestinal tight junction protein (Interleukin-12, Interleukin-15, Tight junction protein ZO-2-like) and anti-in ammatory (Interleukin-10, Transforming growth factor beta 2) mRNA expression, up regulated pri-in ammatory factors (Interleukin-1 β, Interleukin-6, Interleukin-8, Interleukin-12 and Interleukin-15) mRNA expression. Conclusion: Based on the current results, dietary soy iso avone and soy saponin could damage the intestinal structure and changes gut bacteria community of M. albus, and destroyed the intestinal barrier, eventually induced intestinal in ammatory occurring, soy iso avone and soy saponin mixed feed has more serious effect than they single supplemented.

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“…Some studies also showed a significant improvement in homeostasis assessment for the insulin resistance index after lowering the level of SUA (Liu et al, 2015;Takir et al, 2015). Previous researches revealed that the levels of serum C3 and C4 positively correlated with the development of the metabolic syndrome and had been identified as important markers relevant to this disease (Meng et al, 2017;Meng et al, 2018;Xin et al, 2018). The increased activation products of C3 can accelerate the uptake of free fatty acids, the synthesis of triacylglycerol, and inhibit hormone-sensitive lipase in several adipocytes, thus contribute to the development of the metabolic syndrome (Phieler et al, 2013;Barbu et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study

Zhu

et al. 2020

PeerJ

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Objectives This study was aimed to assess the relationship between serum uric acid (SUA) level and the clinical, pathological phenotype of IgA nephropathy (IgAN), and to determine the role of SUA level in the progression and prognosis of IgAN. Methods A total of 208 patients with IgAN were included in this study, and were classified into the normo-uricemia group and hyperuricemia group according to the SUA level. The clinical data at baseline, IgAN Oxford classification scores (MEST-C scoring system), and other pathological features were collected and further analyzed. All patients were followed up and the prognosis was assessed using Kaplan-Meier survival curves. GraphPad Prism 7.0 and SPSS 23.0 were used for statistical analyses. Results In clinical indicators, patients with hyperuricemia had the significantly higher proportion of males to females, mean arterial pressure, the levels of total cholesterol, triglyceride, Scr, BUN, 24 hour-urine protein, C3, and C4, the lower levels of high-density lipoprotein cholesterol and eGFR than those without (p < 0.05). In terms of pathological characteristics, the tubular atrophy/interstitial fibrosis scores, vascular injury scores, and glomerular sclerosis percentage were significantly higher in patients with hyperuricemia compared with those without (p < 0.01). There was no significant difference in the scores of mesangial hypercellularity, endocapillary hypercellularity, focal segmental glomerulosclerosis, as well as crescents between the two groups (p > 0.05). As for the depositions of immune complexes deposition in IgAN, the hyperuricemia group had less deposition of immunoglobulin G and FRA than the normo-uricemia group (p < 0.05), while the deposition of immunoglobulin A, immunoglobulin M, and complement C3 in the two groups showed no statistical difference. The survival curve suggested that patients in the hyperuricemia group have significantly poorer renal outcome than those in the normo-uricemia group (p = 0.0147). Results also revealed that the SUA level is a valuable predictor of renal outcome in patients with IgAN. The optimal cutoff value was 361.1 µmol/L (AUC = 0.76 ± 0.08167) and 614 µmol/L (AUC = 0.5728 ± 0.2029) for female and male, respectively. Conclusions The level of SUA is associated with renal function level and pathological severity of IgAN, and maybe a prognostic indicator of IgAN.

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Complement C3 and C4, but not their regulators or activated products, are associated with incident metabolic syndrome: the CODAM study

Cited by 19 publications

References 43 publications

Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents

Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents

Effects of dietary soy isoflavone and soy saponin on growth performance, intestinal structure, intestinal immunity and gut microbiota community on rice field eel (Monopterus albus)

Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study

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