2024
DOI: 10.1172/jci167665
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Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice

Arijita Jash,
Thomas Pridmore,
James B. Collins
et al.

Abstract: Administration of anti-RhD immunoglobulin (Ig) to decrease maternal alloimmunization (antibody-mediated immune suppression [AMIS]) was a landmark clinical development. However, IgG has potent immune-stimulatory effects in other settings (antibody-mediated immune enhancement [AMIE]). The dominant thinking has been that IgG causes AMIS for antigens on RBCs but AMIE for soluble antigens. However, we have recently reported that IgG against RBC antigens can cause either AMIS or AMIE as a function of an IgG subclass… Show more

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