Complement C4 Is a Marker for Adult Rheumatoid Arthritis

O'Neill, Geoffrey J.; Nerl, ChristophW.; Kay, P.; Christiansen, F.; McCluskey, James; Dawkins, R. L.

doi:10.1016/s0140-6736(82)91057-1

Cited by 35 publications

(17 citation statements)

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“…The high frequency of C4 null alleles and some C4 allotypes like C4B3 in patients with an autoimmune or immune complex disease such as lupus erythematosus [17], rheuma toid arthritis [18] and glomerulonephritis [19], further supports the functional rele vance of C4 polymorphism. It has not been established, however, what role these null alleles play in the clinical picture: do they serve only as a genetic marker for genes pre disposing to those diseases or do they have an active role in the pathogenesis of the dis ease.…”

Section: Resultsmentioning

confidence: 81%

Changes in Plasma Complement C4 and Factor B Allotypes after Liver Transplantation

Koskimies

Lokki²,

Höckerstedt³

1991

Complement Inflamm

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Plasma complement allotypes for C4 and factor B were determined in 21 patients before and after liver transplantation together with donor typing. In 17 transplantations allelic differences between the patient and the donor could be shown. In all cases the patient’s C4 and factor-B types converted to that of the donor, showing that the liver is the major source of plasma complement C4 and factor B.

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Section: Resultsmentioning

confidence: 81%

Changes in Plasma Complement C4 and Factor B Allotypes after Liver Transplantation

Koskimies

Lokki²,

Höckerstedt³

1991

Complement Inflamm

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“…Also, among 350 normal haplotypes the C4B*3 allele is almost always part of this extended haplotype. Recently, using data from random unrelated individuals with RA, it has been inferred that the haplotype, HLA-A2, B15(W62), CW3, DR4, BF*S, C2*C, C4A*3, C4B*3, is associated with RA (13,14). The present study demonstrates that the C4B*3 allele is increased in RA patients selected at random, and from studies in families identified with multiple cases of RA, this extended haplotype has an increased incidence in patients.…”

mentioning

confidence: 99%

Extended haplotypes of chromosome 6 in adult rheumatoid arthritis

Raum

Awdeh

Glass

et al. 1984

Arthritis & Rheumatism

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In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA—‐B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.

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“…[8]) and are, therefore, often difficult to define precisely. This test also excludes the possi bility that nonhemolytically active C4B products exist similar to those which are already known to occur at the C4A locus (C4F1 or C4A6 [9]). …”

Section: Electrophoretic Characterization Of C4mentioning

confidence: 99%

C4 Polymorphism: Use of a Monoclonal Antibody to Distinguish C4A and C4B Locus Products

O'Neill¹

1984

Vox Sanguinis

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A monoclonal antibody reactive against C4B locus products was used in a passive immunoblotting technique to distinguish C4B from C4A electrophoretic variants. The technique is simple and has the advantage ofbeing able to distinguish clearly those C4B variants which may be either difficult to define by conventional hemolytic assay alone or which would normally be designated as C4B products on account of their lack of hemolytic function. Patterns detected by immunoblotting can be compared directly with patterns obtained by immunofixation with anti-C4 from the same gel.

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Complement C4 Is a Marker for Adult Rheumatoid Arthritis

Cited by 35 publications

References 0 publications

Changes in Plasma Complement C4 and Factor B Allotypes after Liver Transplantation

Changes in Plasma Complement C4 and Factor B Allotypes after Liver Transplantation

Extended haplotypes of chromosome 6 in adult rheumatoid arthritis

C4 Polymorphism: Use of a Monoclonal Antibody to Distinguish C4A and C4B Locus Products

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