Complement component consumption in sepsis correlates better with hemostatic system parameters than with inflammatory biomarkers

Lendak, Dajana; Mihajlović, D; Mitić, Gorana; Ubavić, M; Novakov-Mikic, Aleksandra; Boban, Jasmina; Brkić, Snežana

doi:10.1016/j.thromres.2018.08.013

Cited by 16 publications

(12 citation statements)

References 25 publications

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“…At a cut-off value of 25, the AUC (95%CI) was 0.81 (0.761-1.000). While different studies have so far shown the ability of APACHE II scores to predict mortality and similar AUC has been reported in other studies for patients calculating APACHE II for varied causes, as our study has demonstrated the strongest correlation to date with an AUC of 0.81 as compared to 0.65-0.86 in other studies [10][11][12][13][14].…”

Section: Discussionsupporting

confidence: 88%

Prediction of Mortality in Patients After Oncologic Gastrointestinal Surgery: Comparison of the ASA, APACHE II, and POSSUM Scoring Systems

Kisa¹,

Kisa²,

Çevik³

2021

Cureus

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Scoring systems have been developed to predict the expected mortality and morbidity in surgical procedures. In this study, our aim was to compare the ASA (American Society of Anesthesiologists), APACHE (Acute Physiology and Chronic Health Evaluation) II, POSSUM (Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity) scoring systems as predictors of mortality in patients who underwent gastrointestinal oncologic surgery, followed, and were admitted to the intensive care unit during the postoperative period. We examined the files of 82 patients who underwent oncologic gastrointestinal surgery and followed up in the intensive care units (ICUs). The patients' APACHE II scores and predicted mortality rates (PMR) according to the APACHE II, POSSUM, and ASA scores were calculated. The receiver operator characteristic (ROC) curve analysis was used when evaluating the performances of the ASA, APACHE, and POSSUM scoring systems in terms of accurate assessment of mortality. Accordingly, the area under the curve (AUC) = 0.5 no distinction, 0.5

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Section: Discussionsupporting

confidence: 88%

Prediction of Mortality in Patients After Oncologic Gastrointestinal Surgery: Comparison of the ASA, APACHE II, and POSSUM Scoring Systems

Kisa¹,

Kisa²,

Çevik³

2021

Cureus

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“…C3 is the most abundant in the human blood complement system and plays an essential role in the complement activation pathway and is an important inflammatory transmitter . A significant depletion of the complement including C3 was observed in sepsis . In our study, we found that TNF‐α and IL‐1β were higher in CLP, which was inhibited by miR‐574 agomir, and that the down‐regulation of C3 by small RNA interference improved cell viability and suppressed apoptosis evidences by down‐regulating GRP78, CHOP and Caspase‐12 at mRNA levels.…”

Section: Discussionmentioning

confidence: 48%

“…42 A significant depletion of the complement including C3 was observed in sepsis. 22 In our study, we found that TNF-α and IL-1β were higher in CLP, which was inhibited by miR-574 agomir, and that the down-…”

Section: Discussionmentioning

confidence: 56%

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Up‐regulation of microRNA‐574 attenuates lipopolysaccharide‐ or cecal ligation and puncture‐induced sepsis associated with acute lung injury

Sun

2020

Cell Biochemistry & Function

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Acute lung injury (ALI) is the most vulnerable organ in sepsis, however, its underlying mechanism remains unclear. Cell viability and apoptosis were detected by cell counting kit-8 and flow cytometry. The expressions of miR-574, Complement 3 (C3), glucose regulatory protein 78 (GRP78), C/EBP homologous protein (CHOP) and Caspase-12 were determined using quantitative real time (qRT)-PCR and Western blot. Histopathology of mice was stained by haematoxylin and eosin staining. The levels of tumour necrosis factor-α (TNF-α) and interleukin (IL)-1β were determined using ELISA. The expression of miR-574 was positively correlated with cell viability in lipopolysaccharide (LPS)-treated cells. Cell viability was improved and apoptosis was inhibited by mimics. Meanwhile, the levels of GRP78, CHOP and Caspase-12 were suppressed by mimics and agomir in LPS-treated human bronchial epithelial (HBE) cells and cecal ligation and puncture (CLP)-treated mice. In vivo, lung tissue damages were ameliorated by agomir, which also decreased the levels of neutrophils, macrophages and albumin. C3 was a target gene of miR-574 and could be decreased by mimics. SiC3 enhanced cell viability and inhibited apoptosis, however, it suppressed the mRNA levels of GRP78, CHOP and Caspase-12. Up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced endoplasmic reticulum stress (ERS). Significance of the study: Clinically, the mortality rate of ALI induced by sepsis remains at a high level, thus, clarifying the mechanism of induction of ALI through pathogen infection will provide a new target for clinical treatment of ALI. In this study, up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced ERS. Our study provides a deeper understanding of sepsis.

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“…Complement depletion is a typical manifestation and also used as disease activity marker in SLE, and it has been found that it makes patients with SLE vulnerable to infection. In our study, the complements (C3 and C4) are lower in the patients with defective levels of free protein S, especially C3 were found to be associated independently with the low levels of free protein S. A study showed the depletion of complements was correlated positively with protein S as one of various inflammatory parameters in sepsis (Lendak et al 2018). This study could identify the correlation between free protein S and complement levels, which represents not only systemic inflammation clinically, but also the defects in clearance of apoptotic debris as major pathogenesis of SLE.…”

Section: Discussionsupporting

confidence: 49%

Plasma Free Protein S Is Correlated with Disease Activity, but not with Subclinical Atherosclerosis among Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study

Jung

Lee

Kim

et al. 2019

Tohoku J. Exp. Med.

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A defect in clearance of apoptotic materials is pivotal in the pathogenesis of systemic lupus erythematosus (SLE). Protein S participates in the removal of apoptotic remnants and the anticoagulation pathway. The aim of the study was to clarify the relationship between plasma levels of free protein S and the disease activity or subclinical atherosclerosis in SLE. Free protein S was measured by an enzyme-linked immunosorbent assay, and patients were classified into two groups of free protein S levels: low (< 50%) and normal (≥ 50%). One hundred-eleven Korean female patients with SLE were enrolled, and the levels of free protein S were 67.4 ± 19.7%. Carotid plaque was detected in 25 (22.5%) patients. Twenty-one patients with low free protein S had lower hemoglobin (11.4

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Complement component consumption in sepsis correlates better with hemostatic system parameters than with inflammatory biomarkers

Cited by 16 publications

References 25 publications

Prediction of Mortality in Patients After Oncologic Gastrointestinal Surgery: Comparison of the ASA, APACHE II, and POSSUM Scoring Systems

Prediction of Mortality in Patients After Oncologic Gastrointestinal Surgery: Comparison of the ASA, APACHE II, and POSSUM Scoring Systems

Up‐regulation of microRNA‐574 attenuates lipopolysaccharide‐ or cecal ligation and puncture‐induced sepsis associated with acute lung injury

Plasma Free Protein S Is Correlated with Disease Activity, but not with Subclinical Atherosclerosis among Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study

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