Complement contributions to COVID-19

Conway, Edward M.; Pryzdial, Edward L. G.

doi:10.1097/moh.0000000000000724

Cited by 9 publications

(5 citation statements)

References 64 publications

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“…Similarly, complement activation occurs during COVID-19 infection (19). Several reports have indicated a reduction in serum C 3 and C 4 levels in SARS-CoV-2-infected patients (1,(20)(21)(22). It has also been reported that serum C 3 and C 4 levels are reduced in other viral diseases, such as hepatitis B (23).…”

Section: Discussionmentioning

confidence: 98%

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Reduction of Complements C3 and C4 in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection

Rahimi Petrudi,

Mirzaii-Dizgah,

Atashabparvar

et al. 2023

Ann Mil Health Sci Res

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Background: The complement system plays a role in chronic immune activation during viral infections. Objectives: This study aimed to evaluate the levels of saliva and serum complements C3 and C4 in coronavirus disease 2019 (COVID-19) patients and healthy individuals. Methods: This cross-sectional study included 36 severe and 22 critical COVID-19 hospitalized patients and 22 healthy individuals. Serum and unstimulated salivary C3 and C4 levels were assessed using the immunoturbidimetric method and analyzed using one-way analysis of variance (ANOVA) with the Student-Newman-Keuls test as a post hoc analysis. Results: Salivary C3 and C4 levels were significantly lower in patients with severe and critical COVID-19 than in healthy individuals. There was no significant difference between the groups infected with severe and critical COVID-19. Serum C3 and C4 levels were lower in critical COVID-19 patients than in healthy individuals; nevertheless, no significant difference was observed between severe COVID-19 patients and healthy individuals. Additionally, serum C4 levels were lower in critical COVID-19 patients than in severe COVID-19 patients. Conclusions: It appears that serum and salivary C3 and C4 levels decrease in patients with COVID-19 infection.

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Section: Discussionmentioning

confidence: 98%

“…The coronavirus disease 2019 (COVID-19) remains a global concern and continues to claim victims. In severe cases, as with other serious illnesses, there is evidence of changes in serum complement levels (1). Respiratory deterioration in this disease has been associated with increased viral loads and an inadequate immune response (2).…”

Section: Introductionmentioning

confidence: 99%

Reduction of Complements C3 and C4 in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection

Rahimi Petrudi,

Mirzaii-Dizgah,

Atashabparvar

et al. 2023

Ann Mil Health Sci Res

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“…There is abundant evidence from biomarker studies to indicate that complement dysregulation involving all activation pathways is ubiquitous during acute infection with SARS-CoV-2, especially in individuals with severe COVID-19. [10][11][12][13][14][15][16][17] Moreover, admission levels of several complement biomarkers, including the activation fragment Ba, predict outcome in hospitalized patients with acute COVID-19. 10 Progressive changes in the concentrations of some complement biomarkers have also been reported in the context of severe disease.…”

Section: Discussionmentioning

confidence: 99%

“…Dysregulation of the complement cascade has been implicated as a driver of inflammation in many diseases, including acute COVID-19. [9][10][11][12] Indeed, the complement system is markedly dysregulated in severe acute COVID-19, and biomarkers spanning all activation pathways predict disease outcome. 10,[13][14][15][16][17] On the basis of these observations, we hypothesized that complement dysregulation could play a key role in the pathogenesis of long COVID.…”

Section: Introductionmentioning

confidence: 99%

Complement dysregulation is a predictive and therapeutically amenable feature of long COVID

Baillie,

Davies,

Keat

et al. 2023

Preprint

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Background: Long COVID encompasses a heterogeneous set of ongoing symptoms that affect many individuals after recovery from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The underlying biological mechanisms nonetheless remain obscure, precluding accurate diagnosis and effective intervention. Complement dysregulation is a hallmark of acute COVID-19 but has not been investigated as a potential determinant of long COVID. Methods: We quantified a series of complement proteins, including markers of activation and regulation, in plasma samples from healthy convalescent individuals with a confirmed history of infection with SARS-CoV-2 and age/ethnicity/gender/infection/vaccine-matched patients with long COVID. Findings: Markers of classical (C1s-C1INH complex), alternative (Ba, iC3b), and terminal pathway (C5a, TCC) activation were significantly elevated in patients with long COVID. These markers in combination had a receiver operating characteristic predictive power of 0.794. Other complement proteins and regulators were also quantitatively different between healthy convalescent individuals and patients with long COVID. Generalized linear modeling further revealed that a clinically tractable combination of just four of these markers, namely the activation fragments iC3b, TCC, Ba, and C5a, had a predictive power of 0.785. Conclusions: These findings suggest that complement biomarkers could facilitate the diagnosis of long COVID and further suggest that currently available inhibitors of complement activation could be used to treat long COVID. Funding: This work was funded by the National Institute for Health Research (COV-LT2-0041), the PolyBio Research Foundation, and the UK Dementia Research Institute.

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“…COVID-19 emerged as a health emergency in the 21st century across the globe. Despite the hope that the widespread vaccine use will reduce morbidity and mortality associated with COVID-19, the pathogenic and ever-mutating SARS-CoV-2 remains a major global concern [ 24 ]. While many infected individuals were reported to suffer pathological changes in multiple organs and systems such as lung, heart, liver, kidney, and gastrointestinal mucosa, the first organ with pathological changes was the lung, such as lung consolidation, infiltration of inflammatory cytokines, etc.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcomes of lung cancer patients with COVID-19: A systematic review and meta-analysis protocol

Liu

Yang

et al. 2022

PLoS ONE

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Background COVID-19 is spreading rapidly worldwide, and the population is generally susceptible to SARS-CoV-2, especially those with cancer. Hence, our study aims to design a protocol for a systematic review and meta-analysis of the clinical characteristics and prognoses of lung cancer patients with COVID-19. Methods The protocol is prepared following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The literature will be searched in Embase, Pubmed, the Cochrane Library, LitCovid, and CNKI for potentially eligible articles. The quality of the articles will be used in the Newcastle-Ottawa Quality Assessment Scale (NOS) and Cochrane Handbook for Systematic Reviews of Interventions. Statistical analysis will be performed through RevMan 5 software. This review protocol has been registered in PROSPERO (CRD42022306866). Discussion To clarify whether COVID-19 affects the clinical symptoms and prognoses of lung cancer patients. Further study is needed to establish the best evidence-based for the management of lung cancer patients with COVID-19. Conclusion The definitive conclusion will be important to physicians effectively manage lung cancer patients with COVID-19.

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Complement contributions to COVID-19

Cited by 9 publications

References 64 publications

Reduction of Complements C3 and C4 in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection

Reduction of Complements C3 and C4 in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection

Complement dysregulation is a predictive and therapeutically amenable feature of long COVID

Clinical characteristics and outcomes of lung cancer patients with COVID-19: A systematic review and meta-analysis protocol

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