Complément de dose de protons pour les cancers du nasopharynx localement évolués : une expérience de l’institut Curie

Beddok, Arnaud; Feuvret, L.; Noel, George; Bolle, Stéphanie; Deberne, M.; Mammar, Hamid; Chaze, A.; Tourneau, C. Le; Goudjil, F.; Zefkili, S.; Herman, Philippe; Dendale, R.; Calugaru, Valentin

doi:10.1016/j.canrad.2019.01.003

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…After the removal of duplicates, 300 reports were reviewed for inclusion. Two reports were removed due to the availability of newer reports from the same group, 19,20 making the final count of 12 reports meet the inclusion criteria. Of note, several articles were excluded because the patient cohorts are mixed with less than 50% NPCs 21 .…”

Section: Resultsmentioning

confidence: 99%

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

Yahya

Salleh

Nasir

et al. 2023

Asia-Pac J Clncl Oncology

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BackgroundProton and carbon‐ion therapy may spare normal tissues in regions with many critical structures surrounding the target volume. As toxicity outcome data are emerging, we aimed to synthesize the published data for the toxicity outcomes of proton or carbon‐ion therapy (together known as particle beam therapy [PBT]) for primary nasopharyngeal carcinoma (NPC).Materials and methodsWe searched PubMed and Scopus electronic databases to identify original studies reporting toxicity outcomes following PBT of primary NPC. Quality assessment was performed using NIH's Quality Assessment Tool. Reports were extracted for information on demographics, main results, and clinical and dose factors correlates. Meta‐analysis was performed using the random‐effects model.ResultsTwelve studies were selected (six using mixed particle‐photon beams, five performed comparisons to photon‐based therapy). The pooled event rates for acute grade ≥2 toxicities mucositis, dermatitis, xerostomia weight loss are 46% (95% confidence interval [95% CI]—29%–64%, I2 = 87%), 47% (95% CI—28%–67%, I2 = 87%), 16% (95% CI—9%–29%, I2 = 76%), and 36% (95% CI—27%–47%, I2 = 45%), respectively. Only one late endpoint (xerostomia grade ≥2) has sufficient data for analysis with pooled event rate of 9% (95% CI—3%–29%, I2 = 77%), lower than intensity‐modulated radiotherapy 27% (95% CI—10%–54%, I2 = 95%). For most endpoints with significant differences between the PBT and photon‐based therapies, PBT resulted in better outcomes. In two studies where dose distribution was studied, doses to the organs at risk were independent risk factors for toxicities.ConclusionPBT may reduce the risk of acute toxicities for patients treated for primary NPC, likely due to dose reduction to critical structures. The pooled event rate for toxicities derived in this study can be a guide for patient counseling.

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Section: Resultsmentioning

confidence: 99%

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

Yahya

Salleh

Nasir

et al. 2023

Asia-Pac J Clncl Oncology

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“…Radiotherapy (RT) is the mainstay of treatment, although Intensity-modulated RT (IMRT) is preferred now because it has fewer adverse effects (xerostomia, trismus, dysphagia, temporal lobe injury) (16,17). Also, proton therapy represents a promising approach for patients with locally advanced NPC (18)(19)(20). Patients with stage II NPC benefit from concurrent chemoradiotherapy (CRT) with cisplatin (21).…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Carcinoma (NPC): Strong suspicion in persistent otitis media with effusion

Lianou¹,

Zarachi²,

Tsimos³

et al. 2023

Int. J. Sci. Res. Arch.

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Nasopharyngeal carcinoma (NPC) is an intriguing disease with unique epidemiological features. It shows a distinct geographical distribution with well-defined, high-risk ethnic groups, age and gender. This neoplasm exhibits strong associations with the Epstein-Barr virus, dietary and genetic factors. Radiation therapy is the mainstay of treatment and imaging plays a central role in tumor mapping and radiation therapy planning. The purpose of the current manuscript is to present a case of a 65-year-old male patient that examined in the outpatient ENT Department of our hospital, reported a persistent otitis media in the left ear, for about one year. It is important always to raise the suspicion of nasopharyngeal carcinoma, in patients with persistent otologic symptoms, that do not improve despite therapy.

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Proton pencil-beam scanning radiotherapy in the treatment of nasopharyngeal cancer: dosimetric parameters and 2-year results

Kubes

Vondráček

Andrlík

et al. 2020

Eur Arch Otorhinolaryngol

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Complément de dose de protons pour les cancers du nasopharynx localement évolués : une expérience de l’institut Curie

Cited by 4 publications

References 28 publications

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

Toxicity profile of patients treated with proton and carbon‐ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta‐analysis

Nasopharyngeal Carcinoma (NPC): Strong suspicion in persistent otitis media with effusion

Proton pencil-beam scanning radiotherapy in the treatment of nasopharyngeal cancer: dosimetric parameters and 2-year results

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