2010
DOI: 10.1016/j.imbio.2010.02.003
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Complement factor B expression profile in a spontaneous uveitis model

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Cited by 24 publications
(25 citation statements)
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“…Further significantly enriched functional pathways were 'platelet degranulation and response to elevated platelet cytosolic Ca2 + ,' 'lipoprotein metabolism' and 'formation of the fibrin clot' (Table 1). This is in agreement with previous studies from our group that indicate both complement pathway upregulation of central C3 molecule in ERU [19], and the detection of high levels of classical plasma proteins albumin and Immunoglobulin in ERU vitreous samples [20].…”
Section: 1supporting
confidence: 94%
See 1 more Smart Citation
“…Further significantly enriched functional pathways were 'platelet degranulation and response to elevated platelet cytosolic Ca2 + ,' 'lipoprotein metabolism' and 'formation of the fibrin clot' (Table 1). This is in agreement with previous studies from our group that indicate both complement pathway upregulation of central C3 molecule in ERU [19], and the detection of high levels of classical plasma proteins albumin and Immunoglobulin in ERU vitreous samples [20].…”
Section: 1supporting
confidence: 94%
“…Five of the six upregulated proteins were classical plasma proteins, which were also detected as upregulated candidates in this study. One of these was central complement cascade component C3 [5], which was discovered as significantly elevated with 2D experiment and was later confirmed and further characterized as changed through alternate complement pathway in ERU [19].…”
Section: Discussionmentioning
confidence: 84%
“…Treatment with CFB antibodies resulted in suppression of EAAU in animals. 14,18 In addition, CFB gene polymorphisms are associated with multiple inflammatory diseases, such as age-related macular degeneration (AMD), lupus, and atypical hemolytic-uremic syndrome. [19][20][21] Our results provide additional evidence for the involvement of complement system in ocular inflammatory disease-uveitis, especially CFB.…”
Section: Discussionsupporting
confidence: 54%
“…14,29 Via complement activation, the presence of an IgM response toward NF-M may aggravate the process of intraocular inflammation as a whole and thus cause damage that impacts ocular structures and cell populations beyond those that express NF-M.…”
Section: Discussionmentioning
confidence: 99%