“…Grace and Rake (1943) regarded as positive any serum which fixed complement in a 1/4 or higher dilution, but Knott and others (1943) noted that sera from patients with no history or clinical manifestations of the disease often fixed complement in lower dilutions, and that cross reactions with sera from svphilitic patients occurred. Such effects were minimized by the demonstration of rising titres of antibody in successive sera.…”
Section: Preparation Of Yolk-sac Suspensions Of Virusmentioning
“…Grace and Rake (1943) regarded as positive any serum which fixed complement in a 1/4 or higher dilution, but Knott and others (1943) noted that sera from patients with no history or clinical manifestations of the disease often fixed complement in lower dilutions, and that cross reactions with sera from svphilitic patients occurred. Such effects were minimized by the demonstration of rising titres of antibody in successive sera.…”
Section: Preparation Of Yolk-sac Suspensions Of Virusmentioning
“…of cases (Gelperin, 1943;Beeson and Miller, 1944). It must, however, be remembered that the Frei test, once positive, remiains so after the infection has cleared (Grace and Rake, 1943).…”
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