Complement-independent nephrotoxic nephritis in the guinea pig

Couser, William G.; Stilmant, Magda M.; Jermanovich, Nancy B.

doi:10.1038/ki.1977.25

Cited by 43 publications

(15 citation statements)

References 36 publications

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“…These lesions were succeeded by mesangial cell proliferation and glomerular sclerosis. These changes were in accord with those of nephrotoxic glomerulonephritis (2,7,13,16) including those in dogs (18,29).…”

Section: Ultrastructural Study For Asssupporting

confidence: 82%

Alterations in Glomerular Anionic Sites in the Autologous Phase of Canine Anti-Glomerular Basement Membrane Nephritis

et al. 1996

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There have been a few studies on canine nephrotoxic glomerulonephritis produced by anti-glomerular basement membrane serum (AGBM), but these reports have not focused on an alteration in the charge properties of glomerular basement membrane (GBM). In this study, rabbit AGBM or normal rabbit serum (NRS) was given intravenously (2 ml/kg body weight) to 16 male beagle dogs. An alteration of anionic sites (ASs) of GBM was studied quantitatively using polyethyleneimine as a cationic probe by electron microscopy at weeks 1, 2, 4, and 8 postinjection. In AGBM-treated dogs, severe or mild proteinuria continued until week 2. At weeks 4 and 8, there was no significant difference in the intensity of proteinuria between AGBM-and NRS-treated groups. Until week 2 postinjection, there were significantly fewer ASs of GBM in AGBM-treated dogs than in NRS-treated dogs. At week 8, however, there was no difference in ASs of GBM between AGBM-and NRS-treated dogs. The fact that a reduction of glomerular AS occurred in AGBMtreated dogs with severe or mild proteinuria and the recovery of AS in the GBM coincided with an improvement of proteinuria suggested that alteration of the glomerular ASs might play an important role in the pathogenesis of proteinuria in canine anti-GBM nephritis.

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Section: Ultrastructural Study For Asssupporting

confidence: 82%

Alterations in Glomerular Anionic Sites in the Autologous Phase of Canine Anti-Glomerular Basement Membrane Nephritis

et al. 1996

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“…To assess purity and specificity, immunoelectrophoresis and micro-Ouchterlony reactivity in 1% agarose was determined against whole rat serum and to sheep IgG (N. L. Cappel Laboratories Inc., Cochranville, Pa.) (26,27 (11).…”

Section: Antibodiesmentioning

confidence: 99%

A new role for complement in experimental membranous nephropathy in rats.

Salant¹,

Belok²,

Madaio³

et al. 1980

J. Clin. Invest.

272

121

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“…The development of the passive model of Heymann nephritis with heavy proteinuria enabled studies to be done to answer this question. At first glance, the Heymann models looked very similar to models of anti-GBM nephritis in guinea pigs described in the 1970s, models in which glomerular antibody deposition also resulted in heavy proteinuria despite the absence of any significant changes in the glomerulus by light microscopy (a scenario that we recognize today probably represented a predominance of antibodies to the podocyte rather than to GBM) (18). In the guinea pig models, complement activation and deposition did not occur, and proteinuria was completely complement independent.…”

mentioning

confidence: 56%