Complement inhibition alleviates donor brain death-induced liver injury and posttransplant cascade injury by regulating phosphoinositide 3-kinase signaling

Lin, Chengjie; Lei, Biao; Dong, Changxian; Chen, Junze; Chen, Shilian; Jiang, Keqing; Zeng, Yonglian; Su, Huizhao; Hu, Jin; Qiu, Xiaoqiang; Li, Zeyuan; Hu, Zhigao; Yu, Shuiping; Zhang, Cheng; Lu, Shiliu; Atkinson, Carl; Tomlinson, Stephen; Zhong, Fan; Yuan, Guandou; He, Songqing

doi:10.1016/j.ajt.2023.01.019

Cited by 2 publications

(1 citation statement)

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“…The entrance of LPS to the bloodstream leads to the activation of immune cells, and thereby results in the activation of the complement systems [ 27 ], during which the complement C3 will be cleaved to C3a and C3b by C3-convertase [ 28 ]. Moreover, complement activation products could induce liver injury via acting on PI3K signaling pathway [ 29 ]. Previous study in rats indicated that salvianolic acid A could attenuate liver damage through blocking LPS-induced complement terminal activation [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Macleaya cordata isoquinoline alkaloids on lipopolysaccharide-induced liver injury in broilers

Chen,

Yang,

Liu

et al. 2024

Anim Biosci

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Objective: This experiment aimed to explore the protective action of dietary supplementation with isoquinoline alkaloids (IA) from Macleaya cordata on lipopolysaccharide (LPS)-induced liver injury in broilers.Methods: Total 216 healthy broilers were selected in a 21-d trial and assigned randomly to the following 3 treatments: control (CON) group, LPS group, and LPS+IA group. The CON and LPS groups were provided with a basal diet, whereas the LPS+IA group received the basal diet supplemented with 0.6 mg/kg Macleaya cordata IA. Broilers in LPS and LPS+IA groups were intraperitoneally injected with LPS (1 mg/kg body weight) at 17, 19, and 21 days of age, while those in CON group were injected with equivalent amount of saline solution.Results: Results showed LPS injection caused systemic and liver inflammation in broilers, inhibited immune function, and ultimately lead to liver injury. By contrast, supplementation of IA ameliorated LPS-induced adverse change in serum parameters, boosted immunity in LPS+IA group. Furthermore, IA suppressed the elevation of hepatic inflammatory cytokines and caspases levels induced by LPS, as well as the expressions of genes related to the tolllike receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factorkappa B (NF-κB) pathway.Conclusion: Dietary inclusion of 0.6 mg/kg Macleaya cordata IA could enhance immune function of body and inhibit liver damage via inactivating TLR4/MyD88/NF-κB signaling pathway in broilers.

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