Complement Inhibition Reduces Early Erythrolysis, Attenuates Brain Injury, Hydrocephalus, and Iron Accumulation after Intraventricular Hemorrhage in Aged Rats

Zhang, Tianjie; Xia, Fan; Wan, Yingfeng; Xi, Guohua; Ya, Hua; Keep, Richard F.

doi:10.1007/s12975-024-01273-6

Transl. Stroke Res.

2024

DOI: 10.1007/s12975-024-01273-6

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Complement Inhibition Reduces Early Erythrolysis, Attenuates Brain Injury, Hydrocephalus, and Iron Accumulation after Intraventricular Hemorrhage in Aged Rats

Tianjie Zhang,

Fan Xia,

Yingfeng Wan

et al.

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New targets in spontaneous intracerebral hemorrhage

Chiang,

Tsai,

Tsai

2024

Current Opinion in Neurology

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Purpose of review Intracerebral hemorrhage (ICH) is a devastating stroke with limited medical treatments; thus, timely exploration of emerging therapeutic targets is essential. This review focuses on the latest strategies to mitigate secondary brain injury post-ICH other than targeting surgery or hemostasis, addressing a significant gap in clinical practice and highlighting potential improvements in patient outcomes. Recent findings Promising therapeutic targets to reduce secondary brain injury following ICH have recently been identified, including attenuation of iron toxicity and inhibition of ferroptosis, enhancement of endogenous resorption of hematoma, and modulation of perihematomal inflammatory responses and edema. Additionally, novel insights suggest the lymphatic system of the brain may potentially play a role in hematoma clearance and edema management. Various experimental and early-phase clinical trials have demonstrated these approaches may potentially offer clinical benefits, though most research remains in the preliminary stages. Summary Continued research is essential to identify multifaceted treatment strategies for ICH. Clinical translation of these emerging targets could significantly enhance the efficacy of therapeutic interventions and potentially reduce secondary brain damage and improve neurological recovery. Future efforts should focus on large-scale clinical trials to validate these approaches, to pave the way for more effective treatment protocols for spontaneous ICH.

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New targets in spontaneous intracerebral hemorrhage

Chiang,

Tsai,

Tsai

2024

Current Opinion in Neurology

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show abstract

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Complement Inhibition Reduces Early Erythrolysis, Attenuates Brain Injury, Hydrocephalus, and Iron Accumulation after Intraventricular Hemorrhage in Aged Rats

Cited by 1 publication

References 40 publications

New targets in spontaneous intracerebral hemorrhage

New targets in spontaneous intracerebral hemorrhage

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