Complement inhibitory proteins expression in placentas of thrombophilic women

Wirstlein, Przemysław; Jasiński, Piotr; Rajewski, Marcin; Goździewicz, Tomasz; Skrzypczak, Jana

doi:10.5603/fhc.2012.0064

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…In uncomplicated pregnancies, complement system activation is involved in placental development in several stages such as trophoblast invasion of decidua [ 10 , 11 ]. Additionally, trophoblast cells express complement regulatory proteins (DAF/CD55), MCP/CD46, and CD59 to protect against fetal injury, preventing dysregulated complement activation [ 12 ]. Regulation of the complement system is tightly controlled during pregnancy; however, excessive complement activation is harmful to a developing fetus [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy

Santiago

Dombrowski

Kawahara

et al. 2023

Genes

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Malaria in pregnancy (MiP) is a public health problem in malaria-endemic areas, contributing to detrimental outcomes for both mother and fetus. Primigravida and second-time mothers are most affected by severe anemia complications and babies with low birth weight compared to multigravida women. Infected erythrocytes (IE) reach the placenta, activating the immune response by placental monocyte infiltration and inflammation. However, specific markers of MiP result in poor outcomes, such as low birth weight, and intrauterine growth restriction for babies and maternal anemia in women infected with Plasmodium falciparum are limited. In this study, we identified the plasma proteome signature of a mouse model infected with Plasmodium berghei ANKA and pregnant women infected with Plasmodium falciparum infection using quantitative mass spectrometry-based proteomics. A total of 279 and 249 proteins were quantified in murine and human plasma samples, of which 28% and 30% were regulated proteins, respectively. Most of the regulated proteins in both organisms are involved in complement system activation during malaria in pregnancy. CBA anaphylatoxin assay confirmed the complement system activation by the increase in C3a and C4a anaphylatoxins in the infected plasma compared to non-infected plasma. Moreover, correlation analysis showed the association between complement system activation and reduced head circumference in newborns from Pf-infected mothers. The data obtained in this study highlight the correlation between the complement system and immune and newborn outcomes resulting from malaria in pregnancy.

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Section: Introductionmentioning

confidence: 99%

Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy

Santiago

Dombrowski

Kawahara

et al. 2023

Genes

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Histopathology in the placentae of women with antiphospholipid antibodies: A systematic review of the literature

Viall

Chamley

2015

Autoimmunity Reviews

141

107

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Complement activation in the plasma and placentas of women with different subsets of antiphospholipid syndrome

Scambi

Ugolini

Tonello

et al. 2019

American J Rep Immunol

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ProblemAs antiphospholipid antibody‐positive women with adverse pregnancy outcomes have higher plasma complement activation product levels, and the placentas of women with antiphospholipid syndrome (APS) exhibit C4d complement component deposition, complement activation involvement has been hypothesized in APS pregnancy complications.Method of studyPlasma levels of C5a and C5b‐9 complement components of 43 APS non‐pregnant patients and 17 pregnant APS women were measured using enzyme‐linked immunosorbent assay. The results were compared with those of 16 healthy non‐pregnant women and eight healthy pregnant women, respectively. Placenta samples of five APS patients at high risk of pregnancy complications and of five healthy controls were subjected to immunoblotting analysis with specific antibodies to C5b‐9 and CD46, CD55, CD59 complement regulators.ResultsThe mean plasma C5a and C5b‐9 levels were significantly higher in the non‐pregnant APS patients with previous thrombosis ± pregnancy morbidity (P = .0001 and P = .0034, respectively) and in the pregnant APS women with adverse outcomes (P = .0093 for both). Similarly, C5b‐9 amounts were significantly higher in the adverse pregnancy outcome placenta (P = .0115) than in those associated to a favorable outcome. The mean CD46, CD55 and CD59 amounts were, instead, lower, although not always significantly, in the placentas of all the high‐risk APS women with respect to the control placentas.ConclusionData analysis demonstrated that there was significant complement activation in the more severe subset of APS patients and in only the adverse pregnancy outcome APS women. Further studies will clarify whether the lower CD46, CD55, and CD59 expressions in the APS placentas are limited to only high‐risk APS patients.

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Complement inhibitory proteins expression in placentas of thrombophilic women

Cited by 4 publications

References 14 publications

Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy

Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy

Histopathology in the placentae of women with antiphospholipid antibodies: A systematic review of the literature

Complement activation in the plasma and placentas of women with different subsets of antiphospholipid syndrome

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