2015
DOI: 10.1007/978-3-319-18603-0_2
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Complement Interactions with Blood Cells, Endothelial Cells and Microvesicles in Thrombotic and Inflammatory Conditions

Abstract: The complement system is activated in the vasculature during thrombotic and inflammatory conditions. Activation may be associated with chronic inflammation on the endothelial surface leading to complement deposition. Complement mutations allow uninhibited complement activation to occur on platelets, neutrophils, monocytes, and aggregates thereof, as well as on red blood cells and endothelial cells. Furthermore, complement activation on the cells leads to the shedding of cell derived-microvesicles that may expr… Show more

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Cited by 38 publications
(35 citation statements)
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“…Taken together, these data indicated that complement only minimally increases platelet procoagulant properties. Although the effects of C3 deficiency on platelet activation were consistent with prior reports implicating complement interaction with platelets, 47,48 activation of platelets in C5-deficient plasma had no effect on VWF binding ( Figure 2D), P-selectin exposure ( Figure 2E), integrin a IIb b 3 activation (supplemental Figure 2C), the exposure of procoagulant PS (Figure 2F), or platelet-dependent thrombin generation (supplemental Figure 2D). Thus, complement activation influences platelets essentially independent of the terminal C5b-9 complement complex.…”
Section: Significantly Fewer C3supporting
confidence: 78%
“…Taken together, these data indicated that complement only minimally increases platelet procoagulant properties. Although the effects of C3 deficiency on platelet activation were consistent with prior reports implicating complement interaction with platelets, 47,48 activation of platelets in C5-deficient plasma had no effect on VWF binding ( Figure 2D), P-selectin exposure ( Figure 2E), integrin a IIb b 3 activation (supplemental Figure 2C), the exposure of procoagulant PS (Figure 2F), or platelet-dependent thrombin generation (supplemental Figure 2D). Thus, complement activation influences platelets essentially independent of the terminal C5b-9 complement complex.…”
Section: Significantly Fewer C3supporting
confidence: 78%
“…This small difference may potentially be due to the higher sieving coefficient and larger membrane surface area, although as we only made blood side measurements cannot exclude any membrane adsorption. 27 Whereas, previous studies have reported increased microparticle generation, 28 we found that with these dialyzers designed for high volume hemodiafiltration there were no significant increases in microparticles. 14 There was no change in prothrombin times, the aPTT increased, but there was no difference in samples taken pre-and post-dialyzer, suggesting no significant loss during dialyzer passage.…”
Section: Discussioncontrasting
confidence: 66%
“…Our findings may have further implications in the setting of transfusion medicine, as platelet concentrates contain variable amounts of EVs, dependent on the donor, the apheresis system, as well as on storage conditions and age. Platelet transfusions rich in EVs might have detrimental effects particularly in the oncological setting, since there is evidence that platelet EVs enhance the invasive potential of cancer cells 33, 34 .…”
Section: Discussionmentioning
confidence: 99%