1989
DOI: 10.1159/000153884
|View full text |Cite
|
Sign up to set email alerts
|

Complement Phenotypes in Patients with Psoriasis<sup>1</sup>

Abstract: Phenotype frequencies for the complement proteins C4A, C4B, Bf (factor B) and C3 were performed for 49 Caucasian patients with psoriasis. The C4*A6 allele was present in 26.6% of the patients as compared to 5.4% of healthy regional Caucasian controls, p < 0.001, relative risk = 6.28. The C4*A6 allele is known to be in linkage disequilibrium with the HLA B17 allele and to produce a non-functional gene product when it occurs with the B17 allele. HLA B17 is known to be associated with psoriasis in many Caucasian … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
4
0
1

Year Published

1997
1997
2013
2013

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 9 publications
(5 citation statements)
references
References 17 publications
0
4
0
1
Order By: Relevance
“…This latter finding deserves emphasis, because Japanese are genetically distant from Caucasians and associations of psoriasis with several other genes differ in Japanese and Caucasians, e.g. with HLA‐linked genes such as corneodesmosin (Ishihara et al ., 1996 vs. Tazi‐Ahnini et al ., 1999 and Enerbaeck et al ., 2000) and C4 (Whyatt et al ., 1989 vs. Nakagawa et al ., 1991 and Cis l o et al ., 2002), although strikingly concordant association with KIR2DS1 gene was recently described in both populations (Suzuki et al ., 2004; Łuszczek et al ., 2004).…”
Section: Discussionmentioning
confidence: 99%
“…This latter finding deserves emphasis, because Japanese are genetically distant from Caucasians and associations of psoriasis with several other genes differ in Japanese and Caucasians, e.g. with HLA‐linked genes such as corneodesmosin (Ishihara et al ., 1996 vs. Tazi‐Ahnini et al ., 1999 and Enerbaeck et al ., 2000) and C4 (Whyatt et al ., 1989 vs. Nakagawa et al ., 1991 and Cis l o et al ., 2002), although strikingly concordant association with KIR2DS1 gene was recently described in both populations (Suzuki et al ., 2004; Łuszczek et al ., 2004).…”
Section: Discussionmentioning
confidence: 99%
“…This clustering revealed that three major biological functions, previously implicated in psoriasis, were altered: immune cell trafficking and activation, acute phase response, and lipid metabolism ( Figure 1B). The complement factor C3 was identified as being functionally involved in all three of these biological processes (Acevedo and Hammar, 1989;Basset-Sé guin et al, 1993;Wyatt et al, 1989). Besides S100A8-S100A9, the complement factor C3 was within the most significantly upregulated inflammatory proteins in psoriatic epidermis ( Figure 1C).…”
Section: The Epidermal Proteome In Psoriasismentioning
confidence: 96%
“…Several investigators have conducted case control association studies in psoriasis typically concentrating upon genes involved in the regulation of the immune response (10,11) and particularly the major histocompatibility complex [human leucocyte antigen (HLA) region] on the short arm of chromosome 6 (12,13). Of the *To whom correspondence should be addressed.…”
Section: Introductionmentioning
confidence: 99%