2024
DOI: 10.1111/febs.17150
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Complement receptor 4 mediates the clearance of extracellular tau fibrils by microglia

Chang Jae Yoo,
Youngtae Choi,
Eugene Bok
et al.

Abstract: Tauopathies exhibit a characteristic accumulation of misfolded tau aggregates in the brain. Tau pathology shows disease‐specific spatiotemporal propagation through intercellular transmission, which is closely correlated with the progression of clinical manifestations. Therefore, identifying molecular mechanisms that prevent tau propagation is critical for developing therapeutic strategies for tauopathies. The various innate immune receptors, such as complement receptor 3 (CR3) and complement receptor 4 (CR4), … Show more

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