Complement

Regulation of Complement Activity via the Alternative Pathway in Placentas of Mouse Spontaneous Abortions

“…In the autologous tissues, the alternative complement pathway is silenced by factor I and cofactor proteins [6], and Crry has a role in restricting self-attacking complement and anaphylaxis shock [4]. It is hypothesized that the alternative complement pathway, of which regulation is not depended to the specific antigens existing in the abortion placentas likely in the classical pathway, is restricted by Crry especially at the late stage of abortion placentas, which show advancing absorption of dead embryo and degenerating placenta.…”