Complementary/alternative therapies for reducing hot flashes in prostate cancer patients: reevaluating the existing indirect data from studies of breast cancer and postmenopausal women

Moyad, Mark A.

doi:10.1016/s0090-4295(02)01641-2

Cited by 49 publications

(34 citation statements)

References 122 publications

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“…Additional in vivo results demonstrated the ability of licorice root to double activity in skeletal and cardiovascular tissue (Tamir et al, 2000) and its effect on reducing testosterone production in rats (Moyad, 2002). Daily consumption of 7 g of a licorice dietary supplement (0.5 g of glycyrrhizic acid) in seven men significantly reduced serum testosterone within 4 days (Armanini et al, 1999).…”

Section: Licoricementioning

confidence: 94%

“…An herbal mixture including licorice and ginseng as well as six other herbs has shown estrogenic activity and was effective in two cases of hormone-refractory prostate cancer (De la Taille et al, 2000). Other studies have evaluated alternative therapies, such as soy, black cohosh, vitamin E and red clover for their potential use in alleviating hot flashes for prostate cancer patients (Moyad, 2002). A recently published randomized cross-over study on soy food consumption and serum prostate specific antigen (PSA) in men with hyperlipidemia showed lowered LDL, no significant effects on serum PSA, and a reduced calculated risk for CHD (Jenkins et al, 2003).…”

Section: Prostate Cancermentioning

confidence: 99%

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Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

407

278

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Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. The number of articles published on phytoestrogens has risen dramatically in the past couple decades. Further research continues to demonstrate the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. This paper discusses the classification of phytoestrogens, methods of identification, their proposed mechanisms of action and botanical sources for phytoestrogens. The effects of phytoestrogens on breast and prostate cancers, cardiovascular disease, menopausal symptoms and osteoporosis will also be examined including research on benefits and risks.

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Section: Licoricementioning

confidence: 94%

Section: Prostate Cancermentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

407

278

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“…Few RCTs included long-term follow-ups, thus findings remain unclear in terms of the longer effects of the examined interventions for vasomotor symptoms. Findings from healthy women may not generalize to women with breast cancer or other populations because of differences in the underlying aetiology of HFNS [99,102]. In addition, although HFNS in the groups appear to be physiologically similar [103], the higher frequency and severity of symptoms experienced in breast cancer survivors may require more intensive therapies [104].…”

Section: Limitationsmentioning

confidence: 99%

Mind–body interventions for vasomotor symptoms in healthy menopausal women and breast cancer survivors. A systematic review

Stefanopoulou

Grunfeld

2016

Journal of Psychosomatic Obstetrics & Gynecology

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Mind-body therapies are commonly recommended to treat vasomotor symptoms, such as hot flushes and night sweats (HFNS). The purpose of this systematic review was to evaluate the available evidence to date for the efficacy of different mind-body therapies to alleviate HFNS in healthy menopausal women and breast cancer survivors. Randomised controlled trials (RCTs) were identified using seven electronic search engines, direct searches of specific journals, and backwards searches through reference lists of related publications. Outcome measures included HFNS frequency and/or severity or self-reported problem rating at post-treatment. The methodological quality of all studies was systematically assessed using predefined criteria. 26 RCTs met the inclusion criteria.Interventions included yoga (n=5), hypnosis (n=3), mindfulness (n=2), relaxation (n=7), paced breathing (n=4), reflexology (n=1) and cognitive behavioural therapy (CBT) (n=4). Findings were consistent for the effectiveness of CBT and relaxation therapies for alleviating troublesome vasomotor symptoms. For the remaining interventions, although some trials indicated beneficial effects (within groups) at post-treatment and/or follow up, between group findings were mixed and overall, methodological differences across studies failed to provide convincing supporting evidence.Collectively, findings suggest that interventions that include breathing and relaxation techniques, as well as CBT, can be beneficial for alleviating vasomotor symptoms. Additional large, methodologically rigorous trials are needed to establish the efficacy of interventions on vasomotor symptoms, examine long-term outcomes and understand how they work.

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“…Knowledge learned from management of hot flashes in breast cancer and postmenopausal women provides a helpful framework. 4 However, men with prostate cancer are distinctly different from women, and research in this area has been minimal.…”

Section: Hot Flashesmentioning

confidence: 99%

“…3 The mortality rate of prostate cancer in the United States is 10 times higher than in China. 4 Observational nutrition research demonstrates that countries with diets high in animal fat have a greater risk for prostate cancer. 2,3,5 The cause of this observation remains unclear, yet there are biologically sound hypothesis, such as 2,6 • increased exposure to serum androgen due to greater fat mass may initiate or promote prostate cancer cell growth, • excessive consumption of omega-6 fatty acids may initiate or promote prostate cancer cell growth, and • adequate consumption of omega-3 fatty acids may inhibit prostate cancer cell growth.…”

Section: Nutritionmentioning

confidence: 99%

Nursing/Quality-of-Life Perspective

Bauer‐Wu

2003

Integr Cancer Ther

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Nursing/Quality-of-Life PerspectiveThis discussion is written through a nursing lens, which is holistic and has high regard for quality-of-life issues. The essence of oncology nursing practice is to assist individuals with cancer and their families to live as well as possible, beyond the diagnosis and treatment of cancer. Addressing symptoms and psychosocial needs earlier in the disease course rather than later is integral to comprehensive cancer care.Men with prostate cancer can experience myriad physical and psychological symptoms. For this case, the prescribed treatments, neoadjuvant hormonal therapy followed by brachytherapy, have the potential to cause hot flashes, fatigue, bowel inflammation and diarrhea, impotence, incontinence, and depression. These symptoms, individually or in combination, may affect this patient's ability to function and carry out normal activities, thereby affecting his sense of wellbeing, relationships, and overall quality of life. Caring for this patient involves attention to the whole person and amelioration of his symptoms using an integrative care model, using the best of conventional and unconventional practices.Given the number of symptoms that this patient is at risk of experiencing and the breadth of the literature on these symptoms, the focus of this discussion will be on one symptom: hot flashes. The reason for focusing on hot flashes is 2-fold: (1) hot flashes are highly prevalent in men who receive hormonal therapy for prostate cancer and (2) there is no consensus how to treat these hot flashes. Treatment options for hot flashes in men are plentiful and diverse. Clinicians are generally not aware of the extent of the literature in this area. The following is an evidence-based

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Complementary/alternative therapies for reducing hot flashes in prostate cancer patients: reevaluating the existing indirect data from studies of breast cancer and postmenopausal women

Cited by 49 publications

References 122 publications

Phytoestrogens: a review of the present state of research

Phytoestrogens: a review of the present state of research

Mind–body interventions for vasomotor symptoms in healthy menopausal women and breast cancer survivors. A systematic review

Nursing/Quality-of-Life Perspective

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