Complementary and Alternative Medicine

Quezada, Sandra; Briscoe, Jessica; Cross, Raymond K.

doi:10.1097/mib.0000000000000761

Cited by 12 publications

(8 citation statements)

References 52 publications

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“…Recently, microbiome-inspired therapeutics, such as fecal microbiome transplantation, and natural products with potent anti-inflammatory properties, have been promoted as viable alternatives to conventional therapeutics [4]. Numerous nutritional and dietary strategies have been developed to aid the treatment of IBD [5].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous nutritional and dietary strategies have been developed to aid the treatment of IBD [5]. For example, ω-3 polyunsaturated fatty acids (n-3 PUFA) have been extensively evaluated to prevent and treat IBD [4,6]. Though their effects on clinical end points, such as the maintenance of remission, relapse rates, or disease activity indices of ulcerative colitis (UC) and/or Crohn's disease (CD), are still debatable, the ability of n-3 PUFA to attenuate intestinal inflammation is seemingly incontestable and has been observed in several clinical trials (reviewed in [7]).…”

Section: Introductionmentioning

confidence: 99%

“…However, excessive M2 macrophage activation may impair intestinal protection against enteric bacterial infection and can aggravate intestinal injury [17]. Infection of pigs with the whipworm, Trichuris suis, induces a protective Th2 immune response and decreases the production of proinflammatory cytokines [4,18]. Notably, the anti-inflammatory properties of T. suis have been exploited as a complementary therapy in IBD with some success [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models

et al. 2020

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Background: The anti-inflammatory property of ω-3 polyunsaturated fatty acids (PUFA) has been exploited in the management of inflammatory bowel disease (IBD) with promising results. However, it remains unclear if PUFA play a significant role in the resolution of inflammation and promotion of mucosal healing. Krill oil (KO) is a natural product rich in PUFA and the potent antioxidant, astaxanthin. In this study, we attempted to understand the mechanisms through which KO modulates the gut microbiome and metabolome using in vitro and in vivo colitis models and a multi-omics based approach. Results: KO significantly decreased LPS-induced IL1β and TNFα expression in human macrophages in vitro in a dosedependent manner by regulating a broad spectrum of signaling pathways, including NF-κB and NOD-like receptor signaling, and displayed a synergistic effect with COX2 and IKK2 inhibitors in attenuating inflammatory pathways. Moreover, KO was involved in the resolution of inflammation by promoting M2 polarization and enhancing macrophagemediated intracellular bacterial killing. Parasite-dependent intestinal mucosal damage and microbial dysbiosis induced by Trichuris suis infection in pigs were partially restored by feeding KO. KO supplementation reduced the abundance of Rickettsiales and several species of Lactobacillus, which were among the important features identified by random forests analysis contributing to classification accuracy for KO supplementation. Several microbial signatures with strong predictive power for the status of both infection and supplementation were identified. The inhibitory effect of KO on histidine metabolism was identified using untargeted metabolomics. KO supplementation reduced several key metabolites related to histamine metabolism by suppressing the expression of a gene encoding L-histidine decarboxylase in the colon mucosa and reducing histamine biosynthesis of microbial origin. Moreover, the pro-resolving properties of KO were validated using a Citrobacter rodentium-induced Th1-dependent colitis murine model. Further, microbial signatures with high prediction accuracy for colitis-related pathophysiological traits were identified in mice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models

et al. 2020

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“…Although systematic reviews about the effectiveness of CAM on inflammatory bowel disease have been published [19,20], there is still insufficient confirmation of their safety and risk based on scientific evidence for the combination of medical treatment with CAM. Nurses need to collect the latest knowledge about CAM and provide their patients with best-practice evidence.…”

Section: Discussionmentioning

confidence: 99%

Self-Control Trial: A Qualitative Grounded Theory Study on the Decision Making Process in Patients with Ulcerative Colitis Who Choose to Use Complementary and Alternative Medicine

Nunotani¹

2018

JCNRC

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This study aimed to explore the decision-making process in patients with ulcerative colitis who were interested in and chose to use complementary and alternative medicine.Methods: This descriptive study used a grounded theory approach to study the decision-making process in patients with ulcerative colitis, including semi-structured interviews and constant comparative analysis. The study subjects were recruited from a self-help group for patients in Japan. A total of 14 adult patients with ulcerative colitis that was in remission participated in this study. Results:In this grounded theory study of patients with ulcerative colitis who choose to use complementary and alternative medicine, a core category was identified, i.e., "self-control trial," along with five other categories included in the patients' decision-making process: "health condition," "feasibility," "influenced by others," "desire to restore my health," and "distrust." Patients whose health condition was not improved by their current treatment were interested in complementary and alternative medicine. While being influenced by others and examining the feasibility of complementary and alternative medicine, these patients weighed their desire to restore health with their distrust. When their desire to restore health outweighed their distrust, patients chose to use complementary and alternative medicine. Conclusions:This study provides an insight into patients' decision-making processes about their choice of complementary and alternative medicine. Such insights might help nurses to better understand and respect patient choice. The findings may also be useful in the development of support programs addressing concerns about the choice of complementary and alternative medicine by patients with ulcerative colitis.

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“…Recently, the use of natural products as traditional, complementary and alternative medicine (TCAM) is increasing in developed countries. In the United States, complementary and alternative medicine practice has nearly doubled in popularity and acceptance in the last decade [3]. Ethiopia is home to many ethnic groups and cultures, which in turn have contributed to the high diversity of traditional health care knowledge and practices.…”

Section: Introductionmentioning

confidence: 99%

ETM-DB: integrated Ethiopian traditional herbal medicine and phytochemicals database

Bultum

Woyessa

Lee

2019

BMC Complement Altern Med

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Background Recently, there has been an increasing tendency to go back to nature in search of new medicines. To facilitate this, a great deal of effort has been made to compile information on natural products worldwide, and as a result, many ethnic-based traditional medicine databases have been developed. In Ethiopia, there are more than 80 ethnic groups, each having their indigenous knowledge on the use of traditional medicine. About 80% of the population uses traditional medicine for primary health care. Despite this, there is no structured online database for Ethiopian traditional medicine, which limits natural products based drug discovery researches using natural products from this country. Description To develop ETM-DB, online research articles, theses, books, and public databases containing Ethiopian herbal medicine and phytochemicals information were searched. These resources were thoroughly inspected and the necessary data were extracted. Then, we developed a comprehensive online relational database which contains information on 1054 Ethiopian medicinal herbs with 1465 traditional therapeutic uses, 573 multi-herb prescriptions, 4285 compounds, 11,621 human target gene/proteins, covering 5779 herb-phenotype, 1879 prescription-herb, 16,426 herb-compound, 105,202 compound-phenotype, 162,632 compound-gene/protein, and 16,584 phenotype-gene/protein relationships. Using various cheminformatics tools, we obtained predicted physicochemical and absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of ETM-DB compounds. We also evaluated drug-likeness properties of these compounds using FAF-Drugs4 webserver. From the 4285 compounds, 4080 of them passed the FAF-Drugs4 input data curation stage, of which 876 were found to have acceptable drug-likeness properties. Conclusion ETM-DB is the largest, freely accessible, web-based integrated resource on Ethiopian traditional medicine. It provides traditional herbal medicine entities and their relationships in well-structured forms including reference to the sources. The ETM-DB website interface allows users to search the entities using various options provided by the search menu. We hope that our database will expedite drug discovery and development researches from Ethiopian natural products as it contains information on the chemical composition and related human target gene/proteins. The current version of ETM-DB is openly accessible at http://biosoft.kaist.ac.kr/etm .

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Complementary and Alternative Medicine

Cited by 12 publications

References 52 publications

Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models

Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models

Self-Control Trial: A Qualitative Grounded Theory Study on the Decision Making Process in Patients with Ulcerative Colitis Who Choose to Use Complementary and Alternative Medicine

ETM-DB: integrated Ethiopian traditional herbal medicine and phytochemicals database

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