Complementary and Alternative Medicine for Cancer

Robinson, Narda G.

doi:10.1016/b978-1-4377-2362-5.00016-5

Cited by 5 publications

(2 citation statements)

References 132 publications

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“…Evidence showed that petroselinic acid played an important role in the biofilm formation and virulence factor production ( 105 ). The acetyl-11-keto-beta-boswellic acid is known to exhibit potent anti-inflammatory properties in vitro and in vivo ( 106 ). The 11-deoxy-16,16-dimethyl prostaglandin E2 was confirmed to protect against oxidative stress ( 107 ), which is responsible for a variety of degenerative processes including diarrhea ( 108 ).…”

Section: Discussionmentioning

confidence: 99%

Multi-omics strategy reveals potential role of antimicrobial resistance and virulence factor genes responsible for Simmental diarrheic calves caused by Escherichia coli

Shi,

Lan,

Wang

et al. 2024

mSystems

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Escherichia coli ( E. coli ) is reported to be an important pathogen associated with calf diarrhea. Antibiotic resistance genes (ARGs) and virulence factor genes (VFGs) pose a considerable threat to both animal and human health. However, little is known about the characterization of ARGs and VFGs presented in the gut microbiota of diarrheic calves caused by E. coli . In this study, we used multi-omics strategy to analyze the ARG and VFG profiles of Simmental calves with diarrhea caused by E. coli K99. We found that gut bacterial composition and their microbiome metabolic functions varied greatly in diarrheic calves compared to healthy calves. In total, 175 ARGs were identified, and diarrheal calves showed a significantly higher diversity and abundance of ARGs than healthy calves. Simmental calves with diarrhea showed higher association of VFGs with pili function, curli assembly, and ferrienterobactin transport of E. coli . Co-occurrence patterns based on Pearson correlation analysis revealed that E. coli had a highly significant ( P < 0.0001) correlation coefficient (>0.8) with 16 ARGs and 7 VFGs. Metabolomics analysis showed that differentially expressed metabolites in Simmental calves with diarrhea displayed a high correlation with the aforementioned ARGs and VFGs. Phylotype analysis of E. coli genomes showed that the predominant phylogroup B1 in diarrheic Simmental calves was associated with 10 ARGs and 3 VFGs. These findings provide an overview of the diversity and abundance of the gut microbiota in diarrheic calves caused by E. coli and pave the way for further studies on the mechanisms of antibiotic resistance and virulence in the calves affected with diarrhea. IMPORTANCE Simmental is a well-recognized beef cattle breed worldwide. They also suffer significant economic losses due to diarrhea. In this study, fecal metagenomic analysis was applied to characterize the antibiotic resistance gene (ARG) and virulence factor gene (VFG) profiles of diarrheic Simmental calves. We identified key ARGs and VFGs correlated with Escherichia coli isolated from Simmental calves. Additionally, metabolomics analysis showed that differentially expressed metabolites in Simmental calves with diarrhea displayed a high correlation with the aforementioned ARGs and VFGs. Our findings provide an insight into the diversity and abundance of the gut microbiota in diarrheic calves caused by Escherichia coli and pave the way for further studies on the mechanisms of antibiotic resistance and virulence in the diarrheal calves from cattle hosts.

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Section: Discussionmentioning

confidence: 99%

Multi-omics strategy reveals potential role of antimicrobial resistance and virulence factor genes responsible for Simmental diarrheic calves caused by Escherichia coli

Shi,

Lan,

Wang

et al. 2024

mSystems

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“…1,8‐cineole present in L. nobilis , M. communis and many other plant EOs has an antigenotoxic effect and stimulates DNA repair (Aprotosoaie, Luca, Trifan, & Miron, 2018). Boswellic acids present in Boswelia serrata EO (Siddiqui, 2011) have an anti‐inflammatory effect by stabilizing mast cells and decreasing the synthesis of leukotrienes (Robinson, 2012). Geranial and neral present in Myrcianthes fragrans (Armijos et al, 2018) also have an antioxidant effect, the mechanism of which is not fully elucidated (Aprotosoaie et al, 2018).…”

Section: Important Bioactive Compounds In Unani Drugs Used During Epidemicsmentioning

confidence: 99%

Exploring new horizons in health care: A mechanistic review on the potential of Unani medicines in combating epidemics of infectious diseases

Fazil

Nikhat

2020

Phytotherapy Research

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Optimization and Pharmacokinetic Study of Boswellic Acid–Loaded Chitosan-Guggul Gum Nanoparticles Using Box-Behnken Experimental Design

Gaur¹,

Puri²,

Singh³

et al. 2021

J Pharm Innov

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Complementary and Alternative Medicine for Cancer

Cited by 5 publications

References 132 publications

Multi-omics strategy reveals potential role of antimicrobial resistance and virulence factor genes responsible for Simmental diarrheic calves caused by Escherichia coli

Multi-omics strategy reveals potential role of antimicrobial resistance and virulence factor genes responsible for Simmental diarrheic calves caused by Escherichia coli

Exploring new horizons in health care: A mechanistic review on the potential of Unani medicines in combating epidemics of infectious diseases

Optimization and Pharmacokinetic Study of Boswellic Acid–Loaded Chitosan-Guggul Gum Nanoparticles Using Box-Behnken Experimental Design

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