Complementary and alternative medicine use among diabetic patients in Africa: a Kenyan perspective

Matheka, Duncan Mwangangi; Demaio, Alessandro

doi:10.11604/pamj.2013.15.110.2925

Cited by 27 publications

(19 citation statements)

References 13 publications

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“…For instance, there is lack of integration of CAM therapies into African mainstream health care systems. This is despite the World Health Organization (WHO) recommendation to integrate traditional and CAM therapies into national health care systems [9]. Another major concern is the lack of regulation on CAM use, therefore exposing the population to potential harm.…”

Section: Introductionmentioning

confidence: 99%

Lipidaemic and Hepatic Status of Type 2 Diabetic Rats Treated with the Polyherbal Capsule Glucoblock

Briggs

Elechi-Amadi

Ezeiruaku

et al. 2020

JAMPS

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The scourge of diabetes has led to an increase in the use of complementary and alternative medicine. The lack of regulation and control leads to the indiscriminate use of these herbals, with potential risk to patients. Aim: This study evaluates the lipidaemic and hepatic status of type 2 diabetic rats treated with the polyherbal capsule glucoblock. Methodology: A total of 35 male Wistar albino rats weighing between 120-220 g were used for this study. The rats were placed on high fat diet and diabetes was induced by a single intraperitoneal injection of freshly prepared streptozotocin (STZ) (45 mg/kg body wt). Fasting plasma glucose (FPG) was determined using the glucose oxidase method. Total Cholesterol (TC), Triglyceride (TG) and High Density Lipoprotein Cholesterol (HDL-C) were determined using enzymatic methods. Low Density Lipoprotein Cholesterol (LDL-C) was calculated using the Friedewald’s equation. Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) were determined using Reitman-Frankel method, while alkaline phosphatase (ALP) was determined using the colorimetric phenolphthalein method. Liver sections were stained using haematoxylin and eosin (H&E) staining technique, and phytochemical analysis was also done on the herbal capsule. Results: The results show no significant differences in TC levels in all groups compared to the negative control. TG level was significantly higher in the diabetic control group when compared to the negative control. TG level in the singular treatment groups were significantly lower, but the combination group (glibenclamide + glucoblock) showed no significant difference compared to the diabetic control. The negative control had significantly higher HDL-C compared to the diabetic control and treatment groups. There were no significant differences in HDL-C levels in all the treatment groups, when compared to the diabetic control. The negative control had significantly lower LDL-C compared to the diabetic control and treatment groups. There were no significant differences in LDL-C levels in all the treatment groups, when compared to the diabetic control. ALT, AST and ALP levels were significantly higher in the diabetic control, but was significantly reduced to normal levels by the treatments. Liver sections of the negative control showed normal histoarchitecture. The diabetic control showed inflammation and fatty deposition. The treatment groups showed a nearly normal histoarchitecture, with fatty deposits. Conclusion: High fat diet in combination with a sub-diabetic dose of streptozotocin produced significant diabetes in the Wistar rats with dyslipidaemia and elevated liver enzyme levels. The anti-diabetic treatments, glibenclamide and glucoblock did not correct the dyslipidaema caused by diabetes. However, the treatments had equipotent hepatoprotective effect and restored liver enzyme levels to normal as well as improving liver histology.

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Section: Introductionmentioning

confidence: 99%

Lipidaemic and Hepatic Status of Type 2 Diabetic Rats Treated with the Polyherbal Capsule Glucoblock

Briggs

Elechi-Amadi

Ezeiruaku

et al. 2020

JAMPS

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“…With the increased burden of diabetes and the unresolved complications, most patients resort to complementary and alternative medicine (CAM), in which they practice polypharmacy, combining orthodox and herbal drugs, in an attempt to improve the outcomes of their illnesses as well as to improve general well-being. The increased prevalence in the use of CAM by diabetic patients in Africa [7], particularly Nigeria, must be matched with efforts to ascertain the safety as well as the therapeutic efficacies of these drugs. Diawell is a well-known anti-diabetic herbal tablet in Nigeria used by many diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of the Anti-diabetic Polyherbal Drug Diawell in Combination with Metformin on Liver and Lipid Parameters in Type 2 Diabetic Rats

Briggs

Nwachuku

Brown

et al. 2019

JOCAMR

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Type 2 diabetes is one of the most important diseases worldwide. It affects several organ systems including the liver and lipid metabolism. Many herbal formulations have shown anti-diabetic potential, however, their safety and efficacy remain a debate in the medical community. Aim: This study evaluates the therapeutic effects of the anti-diabetic polyherbal drug diawell in combination with metformin on liver enzyme and lipid profile in type 2 diabetic rats. Methodology: A total of 35 male Wistar albino rats weighing between 120-220 g were used for this study. The rats were placed on high fat diet, and diabetes was induced by a single intraperitoneal injection of freshly prepared streptozotocin (STZ) (45 mg/kg body wt). Fasting plasma glucose (FPG) was determined using the glucose oxidase method. Total Cholesterol (TC), Triglyceride (TG) and High density lipoprotein cholesterol (HDL-C) were determined using enzymatic methods. Low density lipoprotein cholesterol (LDL-C) was calculated using the Friedewald equation. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined using Reitman-Frankel method, while alkaline phosphatase (ALP) was determined using the colorimetric phenolphthalein method. Liver sections were stained using haematoxylin and eosin (H&E) staining technique, and phytochemical analysis was also done on the herbal tablet. Results: The results show no significant differences in mean TC levels in all groups. TG level was significantly higher in the diabetic control when compared to the negative control. There were no significant differences in TG levels in the metformin group, and diawell group when compared to the diabetic control. TG levels in the combination group (metformin + diawell) was significantly lower versus the diabetic control, and showed no significant difference compared to the negative control. HDL-C was significantly higher in the negative control when compared to the diabetic control and the treatment groups. There were no significant differences in HDL-C levels in all the treatment groups, when compared to the diabetic control. LDL-C levels were significantly lower in the negative control compared to the diabetic control and treatment groups. There were no significant differences in LDL-C levels in all the treatment groups, when compared to the diabetic control. The diabetic control had significantly higher ALT, AST and ALP levels compared to the negative control and treatment groups. All the treatment groups showed no significant differences in ALT and AST levels compared to the negative control. Liver sections of the negative control showed normal histoarchitecture. The diabetic control showed inflammation and fatty deposition. The treatment groups showed a nearly normal histoarchitecture, with fatty deposits. Conclusion: High fat diet in combination with 45 mg/kg of STZ produced significant diabetes in the Wistar rats with dyslipidaemia and elevated liver enzyme levels. Metformin and the polyherbal tablet diawell had no impact on the lipid levels as it did not correct the dyslipidaema, however, the treatments showed hepatoprotective potentials and restored liver enzyme levels to normal. Lipid lowering drugs should be included in the management of type 2 diabetes, and there should be proper evaluation of anti-diabetic herbal products.

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“…The same had been reported by others. 14,[35][36][37] In the current study, we depend on self-rating of patient`s compliance which usually overestimate patients Compliance levels. 38 Conclusively, rate of non-compliance with anti-diabetic medication among Saudi diabetes is high and significantly associated with young age, younger age at diagnosis, moderate educational level, type 2 diabetes, absence of comorbid diseases, never compliance with physicians' visits, treatment by anti-diabetics, use of traditional medicine and having information about diabetes from the family.…”

Section: Discussion:-mentioning

confidence: 99%

Compliance of Saudi Diabetic Patients With Their Diabetic Medication.

AlDawsari¹,

AlQauyyed²,

Al-Dawsari³

et al. 2016

IJAR

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Background: In recent years there were a lot of studies showing increasing numbers of complication in diabetic patient in the world include Saudi population. Amongst the most important reasons for such complications is the non-adherence of diabetic patient with their medication, diet and exercise. Objectives: To explore the rate and determinants of non-compliance with diabetic treatment regimen in Saudi Arabia population. Subjects and methods: A cross-sectional study was conducted among Saudi diabetic patients. Online approach was adopted to enroll patients through filling the study questionnaire throughout the period between 1st to 30 October, 2016. Inclusion criteria were Saudi, diabetic and have online access patients. Our outcomes were compliance with anti diabetic medication and the associated factors. An online pretested semi-structured questionnaire was utilized for date collection. Results: The study included 1473 Saudi diabetic patients. The age of 31.4% of them ranged between 41 and 60 years. Slightly more than half of them (54.1%) were males, married (52.2%), university educated (50.9%) and 60.1% of them were type 2 diabetic patients. Compliance with physicians` visits was reported by majority of them (80.2%). However, this compliance was perfect among 42.5% of patients. Glycated hemoglobin percentage exceeded 8% among 33.7% of patients. Minority of patients (8.7%) reported difficulty in getting antidiabetic drugs. Using traditional medicine in treating diabetes was reported by 14.7% of the participants; however it was a lot among 2.3% of them. Daily compliance with diabetic drugs was reported among 60.3% of the patients. The commonest reported reasons for escaping a daily dose of anti-diabetic drugs were being not definitely explained by physician (52.7%) and forgetting (21.7%). Most of the participants reported being reminded by family members to have the drugs.The most frequent reported sources of patient`s information regarding diabetes were physicians (69.6%) and internet (59.9%). The determinants of none-compliance to anti-diabetic medications were young age, younger age at diagnosis, moderate educational level, type 2 diabetes, absence of co-morbid diseases, never compliance with physicians visits, treatment by anti-diabetics, use of traditional medicine and having information about diabetes from the family.

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Complementary and alternative medicine use among diabetic patients in Africa: a Kenyan perspective

Cited by 27 publications

References 13 publications

Lipidaemic and Hepatic Status of Type 2 Diabetic Rats Treated with the Polyherbal Capsule Glucoblock

Lipidaemic and Hepatic Status of Type 2 Diabetic Rats Treated with the Polyherbal Capsule Glucoblock

Therapeutic Effects of the Anti-diabetic Polyherbal Drug Diawell in Combination with Metformin on Liver and Lipid Parameters in Type 2 Diabetic Rats

Compliance of Saudi Diabetic Patients With Their Diabetic Medication.

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