Complementary and alternative therapies for restless legs syndrome: An evidence-based systematic review

Xu, Xiaomin; Yang, Licong; Jia, Shiyu; Dong, Mei-Xue; Cao, Du; Wei, You-Dong

doi:10.1016/j.smrv.2017.06.003

Cited by 52 publications

(31 citation statements)

References 62 publications

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“…8 As an alternative therapy, exercise can also be highly efficacious in symptom management. Xu et al 9 suggested that exercise has many beneficial effects on uremic RLS, poor sleep, depression, and low quality of life. In addition, Shahgholian et al's study 2 showed that four weeks of stretching exercises can reduce the severity of RLS symptoms.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exercise Training on Restless Legs Syndrome, Depression, Sleep Quality, and Fatigue Among Hemodialysis Patients: A Systematic Review and Meta-analysis

Song

Diao

et al. 2018

Journal of Pain and Symptom Management

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Section: Introductionmentioning

confidence: 99%

Effects of Exercise Training on Restless Legs Syndrome, Depression, Sleep Quality, and Fatigue Among Hemodialysis Patients: A Systematic Review and Meta-analysis

Song

Diao

et al. 2018

Journal of Pain and Symptom Management

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“…In 2018, a study concluded that RLS symptoms could be significantly reduced through exercise training, transcutaneous spinal direct current stimulation, pneumatic compression devices, light therapy, repetitive transcranial magnetic stimulation, and acupuncture. The authors also reported that exercise training is highly effective in RLS secondary to uremia from ESRD [46]. Endogenous laser ablation would be a better option for patients suffering from RLS with superficial venous insufficiency [46].…”

Section: Therapeutic Approaches To Rlsmentioning

confidence: 98%

“…The authors also reported that exercise training is highly effective in RLS secondary to uremia from ESRD [46]. Endogenous laser ablation would be a better option for patients suffering from RLS with superficial venous insufficiency [46]. In 2019, Harrison et al conducted a trial of treating RLS using non-pharmacological methods.…”

Section: Therapeutic Approaches To Rlsmentioning

confidence: 99%

Unraveling the Mysteries of Restless Leg Syndrome

Memon

Zaveri

Perry

et al. 2020

Cureus

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Restless leg syndrome (RLS) or Willis-Ekbom disease (WED) is an under-diagnosed, chronic, and progressive primary sensory-motor disorder. It is characterized by an uncontrollable urge to move the legs due to uncomfortable and sometimes painful sensations, with a diurnal variation. RLS can lead to severe sleep disturbances, a usual cause of consultation. The pathophysiology is known partially, and it is believed that there is an association between the different variants of genetic mutations combined with dopaminergic and brain iron dysregulation, which plays an important role. The data used for this study were extracted from the articles found in the PubMed database that discuss different gene variants, pathophysiology, and various methods of treatment. They also highlight the role of iron in the pathogenesis of RLS as it is required for the synthesis of tyrosine hydroxylase, which is the rate-limiting step for dopamine synthesis. This review article provides a clinically useful overview of RLS in terms of pathophysiological findings, its genetic associations, and therapeutic options by using the currently available literature. Because RLS presents with vague symptoms and shares similarities with many other diseases, it might be overlooked by many physicians resulting in underdiagnosis and under-treatment. While these discoveries provide a breakthrough in understanding the details of RLS, further studies are recommended as these studies are limited to animal models and provide a limited representation of the general population.

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“…Among the seven acupunctural points mentioned above, only ST36 (Zusanli), GB34 (Yanglingquan), SP9 (Yinlingquan) and KI9 (Zhubin) with electrical stimulation are conducted. The frequency of electrical stimulation is 2 Hz, and the intensities of the stimulation are below 9.8 mA for 15 min [16,17].…”

Section: Intervention Description {11a}mentioning

confidence: 99%

WITHDRAWN: The effect of electroacupuncture on hemodialysis patients with restless legs syndrome (RLS): study protocol for a randomized crossover trial

Chen¹,

Chiu

Chang

et al. 2020

Preprint

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Background The aim of the present study was to evaluate the effects of electroacupuncture (EA) in hemodialysis patients with restless leg syndrome (RLS) by heart rate variability (HRV) monitor. Methods112 subjects who were hemodialysis patients with RLS will be divided into 2 groups: experimental and control. Each subject will receive the treatment relevant to their group 2 times a week for 4 weeks. After 4 weeks of treatment the subject will enter a 2-week washout period, after which the subjects will switch groups. Measurements will include HRV recordings, International Restless Legs Syndrome Rating Scale (IRLSRS) and Insomnia Severity Index (ISI). DiscussionThis study is the first investigation to analyze the relationship between EA and the change of HRV by an objective monitor. If the findings of the current trial are positive, this study will also help support an effective, safe and cheap approach to clinical treatment of this challenging disorder, help foster improved understanding the relationship between RLS and HRV, and ultimately contribute to elucidate the mechanisms of EA. Trial registrationClinicalTrials.gov Identifier: NCT04356794; registration date: April 22, 2020.

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Complementary and alternative therapies for restless legs syndrome: An evidence-based systematic review

Cited by 52 publications

References 62 publications

Effects of Exercise Training on Restless Legs Syndrome, Depression, Sleep Quality, and Fatigue Among Hemodialysis Patients: A Systematic Review and Meta-analysis

Effects of Exercise Training on Restless Legs Syndrome, Depression, Sleep Quality, and Fatigue Among Hemodialysis Patients: A Systematic Review and Meta-analysis

Unraveling the Mysteries of Restless Leg Syndrome

WITHDRAWN: The effect of electroacupuncture on hemodialysis patients with restless legs syndrome (RLS): study protocol for a randomized crossover trial

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