Complementary and alternative therapies for knee osteoarthritis

Yu, Honggang; Wang, Haiyan; Cao, Panju; Ma, Tao; Zhao, Yongli; Xie, Fei-Yang; Yao, Chuanjiang; Zhang, Xiaogang

doi:10.1097/md.0000000000023035

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Currently, cartilage protection still awaits a dedicated pharmaceutical solution. This has prompted interest in complementary and alternative medicine [ 16 , 17 ], including nutraceuticals and herbal remedies believed to possess chondroprotective effects and the ability to stimulate cartilage repair [ 18 , 19 ]. The exploration of traditional medicinal systems for potential drugs aiming at reducing inflammation, safeguarding cartilage, enhancing joint functionality, and reinstating activity levels has become a topic of considerable interest.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of Intra-Articular Injection of Synthetic Deer Antler Peptides in a Rat Model of Knee Osteoarthritis

Hung,

Chen,

Wang

et al. 2024

IJMS

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Synthetic deer antler peptides (TSKYR, TSK, and YR) stimulate the proliferation of human chondrocytes and osteoblasts and increase the chondrocyte content of collagen and glycosamino-glycan in vitro. This study investigated the peptide mixture’s pain relief and chondroprotective effect in a rat model of collagenase-induced osteoarthritis. Thirty-six adult male Sprague–Dawley rats were divided into three groups: control (saline), positive control (hyaluronic acid), and ex-perimental (peptides). Intra-articular collagenase injections were administered on days 1 and 4 to induce osteoarthritis in the left knees of the rats. Two injections of saline, hyaluronic acid, or the peptides were injected into the same knees of each corresponding group at the beginning of week one and two, respectively. Joint swelling, arthritic pain, and histopathological changes were evaluated. Injection of the peptides significantly reduced arthritic pain compared to the control group, as evidenced by the closer-to-normal weight-bearing and paw withdrawal threshold test results. Histological analyses showed reduced cartilage matrix loss and improved total cartilage degeneration score in the experimental versus the control group. Our findings suggest that intra-articular injection of synthetic deer antler peptides is a promising treatment for osteoarthritis.

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Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of Intra-Articular Injection of Synthetic Deer Antler Peptides in a Rat Model of Knee Osteoarthritis

Hung,

Chen,

Wang

et al. 2024

IJMS

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“…4 Owing to the side effects associated with the use of pharmacological management of OA, 5 there has been a major shift in the use of Complementary and Alternative Medicine (CAM) therapies. 6,7 Few studies [8][9][10][11] suggested homeopathy to be effective in the management of OA but no such definitive conclusion could be made. In this regard, a randomised placebo-controlled trial was conducted to assess the efficacy of individualised homeopathic medicines in the treatment of OA.…”

Section: Introductionmentioning

confidence: 99%

A Randomised Placebo-Controlled Clinical Trial of Homeopathic Medicines on Osteoarthritis

et al. 2023

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Background Osteoarthritis (OA) is one of the most common musculoskeletal disorders present worldwide. It increases with age and is prevalent among elderly people affecting their daily activities thus adding to the economic burden. Objectives This clinical study was undertaken to assess the efficacy of homeopathic medicines in the treatment of OA. Methods This single-blind, randomised, placebo-controlled, clinical trial was conducted on 90 patients suffering from OA. Each patient was randomised into an intervention group (IG) and a control group (CG). The IG (n = 60) received individualised homeopathic medicine (IHM) based on the symptom similarity of the case. The CG (n = 30) received an identical-looking placebo. Outcome assessment was done by assessing the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores at the baseline and after 3 months of follow-up. Paired t-test was used to determine differences between before and after treatment within groups. Results The difference in the WOMAC index score before and after treatment in the CG was found non-significant (p = 0.96), while in the IG the difference was statistically significant (p < 0.05) at a 95% of confidence level. The most useful medicines indicated were Bryonia alba, Medorrhinum, Pulsatilla pratensis, Rhus toxicodendron, Arnica montana, Causticum and Sulphur. Conclusion Patients with OA reported a significant decrease in WOMAC index score after 3 months of homeopathic treatment based on the totality of symptoms.

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“…Considering the escalation in the number of cases of osteoarthritis today, even with advanced medical technology, this research study aims to gather information about every aspect of the topic of interest [ 3 , 4 ]. Along with surgeries, an alternative approach for the treatment of osteoarthritis was the focus of this research for the benefit of public health globally [ 5 , 6 ]. Bibliometric analysis is one such tool where qualitative and quantitative statistical analysis of all the articles and of all types, is carried out [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Growing Trends in Scientific Publication in Physiotherapy Treatment of Knee Osteoarthritis: A Bibliometric Literature Analysis

Joshi,

Kulkarni,

Wadhokar

et al. 2023

Cureus

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There has been an increase in the life expectancy of people worldwide, especially in developing countries like India. Osteoarthritis, a condition that usually onsets during later decades of life, has also been on the rise, even with advancing technology. This has led osteoarthritis of the knee to become a global disabling condition of the lower extremity that increases dependency on the affected individual. A bibliometric study has not been conducted on knee osteoarthritis research. Therefore, a bibliometric analysis which includes statistical analysis of recent articles, books, and other forms of publications is done for evaluation of scientific output and to find the importance of scientific studies in terms of quality as well as quantity. The aim of this analysis was to evaluate the productivity of research articles indexed in PubMed related to the condition. The PubMed database was used and articles related to osteoarthritis of the knee, phonophoresis, and start excursion balance test were extracted. In the bib text format, all the files were downloaded and placed together. The R studio software (R Foundation for Statistical Computing, Vienna, Austria) for bibliometric analysis was then used, into which the research data was uploaded and a data framework of bibliometric analysis was made. Analysis of bibliometric publications related to knee osteoarthritis, phonophoresis, Otago exercises, star excursion balance test, ultrasound, and exercise therapy generated between 1989 and 2021 lists a total of 120 relevant documents from 75 sources with an average of 4.53 articles per year of publication. The use of an advanced PubMed database enables the extraction of adequate articles and powerful bibliometric analysis of the studies conducted on osteoarthritis of the knee published from 1989 to 2021. It includes an assessment of the contributions from major countries. This study allowed us to validate our methodology which can be used to evaluate research policies and promote international collaboration.

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Complementary and alternative therapies for knee osteoarthritis

Cited by 5 publications

References 43 publications

The Therapeutic Potential of Intra-Articular Injection of Synthetic Deer Antler Peptides in a Rat Model of Knee Osteoarthritis

The Therapeutic Potential of Intra-Articular Injection of Synthetic Deer Antler Peptides in a Rat Model of Knee Osteoarthritis

A Randomised Placebo-Controlled Clinical Trial of Homeopathic Medicines on Osteoarthritis

Growing Trends in Scientific Publication in Physiotherapy Treatment of Knee Osteoarthritis: A Bibliometric Literature Analysis

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