2000
DOI: 10.1007/s003950070035
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Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of Ginkgo biloba extract (EGb 761) during ischemia and reperfusion

Abstract: Hemodynamic and electron spin resonance (ESR) analyses were performed on isolated ischemic and reperfused rat hearts to assess the cardioprotective and antioxidant effects of therapeutically relevant concentrations of Ginkgo biloba extract (EGb 761; 5, 50 or 200 microg/ml), its terpenoid constituents (ginkgolide A; 0.05 microg/ml and ginkgolide B; 0.05, 0.25 or 0.50 microg/ml), and a terpene-free fraction of EGb 761 (CP 205; 5 or 50 microg/ml). Hearts underwent 10 min of low-flow ischemia, 30 min of no-flow gl… Show more

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Cited by 87 publications
(56 citation statements)
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“…There has been recent evidence that ginkgolides B and A also display interesting activity as antiischemic cardioprotectors [Pietri et al, 1997;Liebgott et al, 2000], but the extent of how this latter property could be intrinsic to this class of molecules remains unknown because PAF inhibition is one of the mechanisms that may be effective in relieving the ischemic-reperfusion syndrome [Koltai et al, 1989]. In recent studies on cell cultures [Masson et al, 1994;Rapin et al, 1994;Janssens et al, 1995;Krieglstein et al, 1995;Rapin et al, 1998], subcellular components [Janssens et al, 1999], isolated hearts [Pietri et al, 1997;Liebgott et al, 2000], or in an vivo model of rat cerebral ischemia [Krieglstein, 1995], it has been proposed that terpenoids, including ginkgolides A and B, and bilobalide could display pharmacological properties unrelated to PAF antagonism.…”
Section: Chemistrymentioning
confidence: 99%
“…There has been recent evidence that ginkgolides B and A also display interesting activity as antiischemic cardioprotectors [Pietri et al, 1997;Liebgott et al, 2000], but the extent of how this latter property could be intrinsic to this class of molecules remains unknown because PAF inhibition is one of the mechanisms that may be effective in relieving the ischemic-reperfusion syndrome [Koltai et al, 1989]. In recent studies on cell cultures [Masson et al, 1994;Rapin et al, 1994;Janssens et al, 1995;Krieglstein et al, 1995;Rapin et al, 1998], subcellular components [Janssens et al, 1999], isolated hearts [Pietri et al, 1997;Liebgott et al, 2000], or in an vivo model of rat cerebral ischemia [Krieglstein, 1995], it has been proposed that terpenoids, including ginkgolides A and B, and bilobalide could display pharmacological properties unrelated to PAF antagonism.…”
Section: Chemistrymentioning
confidence: 99%
“…Nestes estudos os autores relataram obtenção de redução significativa na incidência e tempo de duração da taquicardia e fibrilação ventricular 15,16,25 . Foram ainda relatados a melhora no fluxo coronário, fluxo aórtico, pressão sistólica, pressão desenvolvida pelo ventrículo esquerdo, pressão diastólica final do ventrículo esquerdo e na primeira derivação da pressão sistólica 6,9,12,18,20,22,24,26 , e a recuperação da força contrátil 17,25 . A recuperação destes componentes da função cardíaca parece ser dependente da presença de vasorrelaxantes como a antraquinona 17 e o óxido nítrico 6 , neste caso, através da ativação da fosfatidilinositol-3-cinase (PI3K), Akt 22 e eNOS 12 .…”
Section: Discussionunclassified
“…Similarly, ginkgolides were shown to have cardioprotective effects, with GA (1) being the most effective. [194,199] To prove that this effect was not related to PAFR antagonism, a GC (3) derivative with a tolyl group at 7-OH was synthesized. This derivative showed improved cardioprotective activity relative to GB (2) and GC (3), while having no effect at the PAFR at 120 mm.…”
Section: Various Effects Of the Ginkgolidesmentioning
confidence: 99%