Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases

Bio-analytical chiral chromatography method for the enantioselective separation of carbinoxamine maleate in human plasma

“…n-Hexane was given first preference as it is comparatively green (Paul et al 2012). For separation of most of the analytes containing basic and/or acidic functional groups, the additive plays a major role in increasing the chromatographic efficiency (Zhang et al 2012). The additives were used in the present word in order to improve the peak shape.…”

Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC

“…However, the advantage of the immobilized CSPs lies in their universal use due to compatibility with many different solvents and one column gives the possibility of changes among different separation modes. The immobilized CSPs have been mostly employed in the NP and PO modes [7,9,10]. However, a few application reports under RP conditions can be found in the literature, too [11][12][13].…”

“…The columns with immobilized phases are multimodal, i.e. can be used in any separation modes, while coated ones are designed just for the given mode (NP or RP) [6,7]. The coated CSPs exhibit better enantioseparation ability for certain analytes [6,8].…”

Simultaneous Enantiomer Separation of α-Amino Acids and Their Esters as Fluorenylmethoxycarbonyl Derivatives under UV and Fluorescence Detection by High Performance Liquid Chromatography

“…그런 결점들을 극복하기 위해 키랄선택자인 다당류 유도체 를 공유결합으로 고정시킨 컬럼들이 그 이후에 개발되었는 데, 이러한 키랄선택자가 공유결합된 키랄 컬럼들을 이용한 순상 크로마토그래피에서 기존의 키랄선택자가 흡착된 키랄 컬럼에서는 허용되지 않았던 halogenated solvents 같은 용매 들을 이동상으로 사용한 여러 연구들이 보고되었다 [4][5][6][7][8][9]. 최 근 amylose tris(3,5-dichlorophenylcarbamate)을 키랄선택자 로 사용하여 실리카 젤에 공유결합된 새로운 Chiralpak IE 키 랄컬럼이 소개되었다 [10][11][12]. 그러나 실제적인 많은 광학분 리연구가 많이 진행되지 않아 아직까지 이 컬럼의 특성이 깊 이 연구되지 않은 상태이며, 보고된 몇 개의 소수의 연구도 supercritical fluid chromatography에 주로 초점이 맞추어져 있 다.…”