2016
DOI: 10.1016/j.ydbio.2016.05.020
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Complementary expression of optomotor-blind and the Iroquois complex promotes fold formation to separate wing notum and hinge territories

Abstract: Animal morphogenesis requires folds or clefts to separate populations of cells which are often associated with different cell affinities. In the Drosophila wing imaginal disc, the regional expression of the Iroquois complex (Iro-C) in the notum leads to the formation of the hinge/notum (H/N) fold that separates the wing hinge and notum territories. Although Decapentaplegic (Dpp) signaling has been revealed as essential for the hinge/notum subdivision through the restriction of Iro-C toward the notum region, th… Show more

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Cited by 18 publications
(16 citation statements)
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“…A key transcription factor in the development of the notum is Mirror (Mirr) ( Diez del Corral et al, 1999 ). The boundary between the notum and the hinge is located at a prominent fold at the edge of the mirr-lacZ expression domain ( Wang et al, 2016 ) ( Figure 4D ). We observed the ectopic Wg expression in the notum within the mirr-lacZ expression domain ( Figure 4E ), and evidence of a new notum/hinge boundary in the ectopic growth ( Figure 4F ).…”
Section: Resultsmentioning
confidence: 99%
“…A key transcription factor in the development of the notum is Mirror (Mirr) ( Diez del Corral et al, 1999 ). The boundary between the notum and the hinge is located at a prominent fold at the edge of the mirr-lacZ expression domain ( Wang et al, 2016 ) ( Figure 4D ). We observed the ectopic Wg expression in the notum within the mirr-lacZ expression domain ( Figure 4E ), and evidence of a new notum/hinge boundary in the ectopic growth ( Figure 4F ).…”
Section: Resultsmentioning
confidence: 99%
“…1a-l ). The mechanisms that position these folds have been studied 19 22 , however, the mechanical forces that drive formation of these folds are unknown.
Fig.
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Section: Introductionmentioning
confidence: 99%
“…The most distal of these, the blade/hinge fold develops under control of the Omb-related T-box transcription factors Dorsocross (Doc)39. The proximal notum/hinge fold requires the complementary expression of Omb in hinge and Iroquois complex (Iro-C) in notum40. In contrast, the A/P compartment boundary is not associated with a fold and remains morphologically inconspicuous throughout development41, even though it derives from the corresponding infolded parasegmental boundary in the embryonic ectoderm42.…”
mentioning
confidence: 99%