Complementary expression of parvalbumin and calbindin D‐28k delineates subdivisions of the rabbit medial geniculate body

Venecia, Ronald K. de; Smelser, Chad; Lossman, Scott D.; McMullen, Nathaniel T.

doi:10.1002/cne.903590407

Cited by 51 publications

(47 citation statements)

References 95 publications

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“…1) as defined in the rabbit by Jones (1985). This area corresponds to the medial and internal divisions of the MG nucleus as defined by De Venecia et al (1995). TIA was localized within these same areas in previous studies using the present procedures and in studies with other procedures (Gabriel et al, 1975(Gabriel et al, , 1976Supple and Kapp, 1989;Hocherman and Yirmiya, 1990;McEchron et al, 1995;O'Connor et al, 1997).…”

Section: Histologysupporting

confidence: 61%

Amygdalar Efferents Initiate Auditory Thalamic Discriminative Training-Induced Neuronal Activity

Poremba

Gabriel

2001

J. Neurosci.

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It is well known that neurons of the medial geniculate (MG) nucleus of the thalamus send axonal projections to the amygdala. It has been proposed that these projections supply information that supports amygdalar associative processes underlying acquisition of acoustically cued conditioning and learning. Here we demonstrate the reverse direction of influence. Temporary inactivation of the amygdala using the GABA A receptor agonist muscimol just before the onset of discriminative avoidance conditioning permanently blocked the development of training-induced discriminative neuronal activity in the MG nucleus of rabbits. No discriminative activity developed when the amygdala was inactivated or during later training to criterion without muscimol. Thus, amygdalar processing at the outset of training is necessary for the development of training-induced discriminative activity of neurons in the MG nucleus.Key words: muscimol; GABA A agonist; temporary lesion; rabbits; associative conditioning; retention; multiunit neuronal activity It is well established that neurons in the amygdala and the medial geniculate (MG) nucleus, the auditory region of the sensory thalamus, are importantly involved in mediating acoustically cued Pavlovian and instrumental aversive conditioning Jarrell et al., 1986;LeDoux et al., 1986;McEchron et al., 1995;Maren and Fanselow, 1996;Davis, 1997; Poremba and Gabriel, 1997a,b;Armony et al., 1998;Ferry et al., 1999). Yet controversy remains as to the separate and distinct contributions of these nuclei, and little is known about how their neurons interact in mediating learning and performance.These issues could have been neatly resolved years ago had it been possible to confirm the hypothesis that neurons of the MG nucleus act simply to relay acoustic data to the amygdala via the direct axonal pathway documented by LeDoux et al. (1985). On this simple view, the function of MG nuclear neurons is sensory coding and transmission of acoustic signals. Interaction within the amygdala of the acoustic information with information concerning reinforcing stimuli would promote the development of plasticity at amygdalar synapses, which would thenceforth allow amygdalar neurons to respond uniquely to associatively significant acoustic cues, thus inducing the output of learned emotional responses and behaviors in other parts of the learning-relevant circuitry.A finding not easily incorporated into the foregoing model is the occurrence of training-induced associative neuronal activity, not simply sensory transmission, in the MG nucleus itself. For example, conditioning-induced, brief-latency discriminative neuronal activity develops in the medial region of the MG nucleus, and this activity exhibits reversal, during acquisition and reversal learning of a discriminative avoidance response (for review, see Gabriel et al., 1982). In the discriminative avoidance task, rabbits learn to avoid a foot shock by locomoting in response to a tone, the positive conditional stimulus (CSϩ), and they ignore a different tone, the CS...

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Section: Histologysupporting

confidence: 61%

Amygdalar Efferents Initiate Auditory Thalamic Discriminative Training-Induced Neuronal Activity

Poremba

Gabriel

2001

J. Neurosci.

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“…Within this area, referred to elsewhere as the internal nucleus (e.g., DeVenecia et al, 1995) and the zone of transition , the architectural properties of the surrounding three nuclei overlapped, blurring the borders between nuclei. In our material stained using the Nissl method, small, medium, and large cells were found within this zone (Z).…”

Section: Thalamic Architecture and Subdivisionsmentioning

confidence: 98%

Thalamocortical connections of the parabelt auditory cortex in macaque monkeys

1998

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The auditory cortex of macaque monkeys contains a core of primary-like areas surrounded by a narrow belt of associated fields that encompass much of the superior temporal plane in these animals. Adjacent to the lateral belt on the superior temporal gyrus is a parabelt region that contains at least two subdivisions (rostral and caudal). In a previous study (Hackett et al. [1998] J. Comp. Neurol. 394:475-495), we determined that the parabelt has topographic connections with the belt areas surrounding the core, but minimal connections with the core itself. In this study, we describe the thalamocortical connections of the parabelt auditory cortex based on multiple injections of neuronal tracers into this region in each of five macaque monkeys. Injections confined to the parabelt labeled large numbers of neurons in the dorsal (MGd) and magnocellular (MGm) divisions of the medial geniculate complex (MGC), suprageniculate (Sg), limitans (Lim), and medial pulvinar (PM) nuclei. Only when injections encroached on the lateral belt cortex were substantial numbers of labeled neurons found in the ventral (MGv) division of the MGC, consistent with the absence of significant connections between the parabelt and core fields. The rostrocaudal topography of the parabelt region was maintained in the thalamocortical connections, supporting the parcellation of this region of cortex. The results suggest that the parabelt region represents a third level of auditory cortical processing, which is not influenced by direct inputs from primary cortical or subcortical auditory structures.

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“…In other regions of the central nervous system, neurochemical techniques, including enzyme histochemistry and immunohistochemistry, have shown anatomical subdivisions not apparent in cell or fiber stains. Examples include staining for cytochrome oxidase in visual cortex (Horton and Hubel 1981), and acetylcholinesterase in the superior colliculus and striatum (Graybiel and Ragsdale 1978;Graybiel 1983;Chevalier and Mana 2000), immunoreactivity to nitric oxide synthase in the nucleus prepositus hypoglossi (Moreno-Lopez et al 2001), immunoreactivity to zebrin in the cerebellum (Sillitoe et al 2003), and immunoreactivity to calcium-binding proteins in thalamus and cortex Jones 1991a, 1991b;Rausell et al 1992;Cusick et al 1993;de Venecia et al 1995;Jones et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Immunoreactivity for calcium-binding proteins defines subregions of the vestibular nuclear complex of the cat

Baizer

Baker

2005

Exp Brain Res

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The vestibular nuclear complex (VNC) is classically divided into four nuclei on the basis of cytoarchitectonics. However, anatomical data on the distribution of afferents to the VNC and the distribution of cells of origin of different efferent pathways suggest a more complex internal organization. Immunoreactivity for calcium-binding proteins has proven useful in many areas of the brain for revealing structure not visible with cell, fiber or Golgi stains. We have looked at the VNC of the cat using immunoreactivity for the calcium-binding proteins calbindin, calretinin and parvalbumin. Immunoreactivity for calretinin revealed a small, intensely stained region of cell bodies and processes just beneath the fourth ventricle in the medial vestibular nucleus. A presumably homologous region has been described in rodents. The calretinin-immunoreactive cells in this region were also immunoreactive for choline acetyltransferase. Evidence from other studies suggests that the calretinin region contributes to pathways involved in eye movement modulation but not generation. There were focal dense regions of fibers immunoreactive to calbindin in the medial and inferior nuclei, with an especially dense region of label at the border of the medial nucleus and the nucleus prepositus hypoglossi. There is anatomical evidence that suggests that the likely source of these calbindin-immunoreactive fibers is the flocculus of the cerebellum. The distribution of calbindin-immunoreactive fibers in the lateral and superior nuclei was much more uniform. Immunoreactivity to parvalbumin was widespread in fibers distributed throughout the VNC. The results suggest that neurochemical techniques may help to reveal the internal complexity in VNC organization.

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Complementary expression of parvalbumin and calbindin D‐28k delineates subdivisions of the rabbit medial geniculate body

Cited by 51 publications

References 95 publications

Amygdalar Efferents Initiate Auditory Thalamic Discriminative Training-Induced Neuronal Activity

Amygdalar Efferents Initiate Auditory Thalamic Discriminative Training-Induced Neuronal Activity

Thalamocortical connections of the parabelt auditory cortex in macaque monkeys

Immunoreactivity for calcium-binding proteins defines subregions of the vestibular nuclear complex of the cat

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