Complementary measurement of nontyphoidal Salmonella-specific IgG and IgA antibodies in oral fluid and serum

Elias, Sean C.; Muthumbi, Esther; Mwanzu, Alfred; Wanjiku, Perpetual; Mutiso, Agnes; Simon, Raphael; MacLennan, Calman A.

doi:10.1016/j.heliyon.2022.e12071

Cited by 1 publication

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IgG levels in oral fluid increased significantly from 8 to 12 times, compared to the control, that indicates a state of hyperreactivity of oral mucosa, mainly a humoral response by a systemic type instead of a secretory one. At the same time, IgG has an anti-inflammatory orientation, ensuring the retention and elimination of foreign antigens by inflammatory mechanisms within the proper oral mucosa [18].…”

Section: Figure 1 -Oral Hygiene Status According To the Ohi-s Index I...mentioning

confidence: 99%

“…It should be noted that the increased concentration of this immune protein is formed as a result of certain disorders in the oral mucosa [14,18]. Presumably, part of the monomeric IgA has a vascular origin, and the other part is formed due to the splitting of the secretory IgA structure into separate fragments that are not able to agglutinate microorganisms and prevent bacterial adhesion to epithelial cells.…”

Section: Figure 1 -Oral Hygiene Status According To the Ohi-s Index I...mentioning

confidence: 99%

See 1 more Smart Citation

Assessing Mucosal Immunity in Patients With Oral Diseases Associated With Rheumatoid Arthritis

Povsheniuk,

Gadzhula,

Rekun

2024

EUMJ

View full text Add to dashboard Cite

Introduction. The association between diseases of connective tissue and oral cavity are of increased interest for scientists because they can contribute to the burden of the pathological process of each other and the occurrence of recurrences. Given that autoimmune disorders in rheumatoid arthritis are the main ones, it is advisable to study the specific and non-specific immunity features of the oral cavity in associated diseases. Methods. The research group included 19 patients with benign migratory glossitis and 16 patients with atrophic glossitis. 15 practically healthy persons made up the control group. The levels of IgA, IgG and lysozyme were determined by radial immunodiffusion according to Mancini method and with the use of biomass powder of Micrococcus lysodeicticus, respectively. Statistical analysis of the obtained results was performed using Statistica 6.1. Results. The high levels of IgG in the oral fluid was found in both research groups (p<0.001). In patients with benign migratory glossitis, high levels of secretory IgA (p>0.05) and serum IgA (p<0.001) were found, while in patients with atrophic glossitis associated with rheumatoid arthritis, there was a significant decrease in the content of sIgA and lysozyme, and similar increase in mIgA content. Conclusions. Oral mucosal diseases associated with RA are accompanied by suppression of defense mechanisms of the oral cavity and its local immunity, which is characterized by a decrease in the levels of lysozyme and secretory IgA in the oral fluid of patients.

show abstract

Section: Figure 1 -Oral Hygiene Status According To the Ohi-s Index I...mentioning

confidence: 99%

Section: Figure 1 -Oral Hygiene Status According To the Ohi-s Index I...mentioning

confidence: 99%

Assessing Mucosal Immunity in Patients With Oral Diseases Associated With Rheumatoid Arthritis

Povsheniuk,

Gadzhula,

Rekun

2024

EUMJ

View full text Add to dashboard Cite

show abstract

Complementary measurement of nontyphoidal Salmonella-specific IgG and IgA antibodies in oral fluid and serum

Cited by 1 publication

References 74 publications

Assessing Mucosal Immunity in Patients With Oral Diseases Associated With Rheumatoid Arthritis

Assessing Mucosal Immunity in Patients With Oral Diseases Associated With Rheumatoid Arthritis

Contact Info

Product

Resources

About