Complementary Modulation of Somatic Inhibition by Opioids and Cannabinoids

Glickfeld, Lindsey L.; Atallah, Bassam V.; Scanziani, Massimo

doi:10.1523/jneurosci.4700-07.2008

Cited by 81 publications

(95 citation statements)

References 47 publications

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“…In those brain regions, however, feedforward inhibition is mainly mediated by perisomatic fast-spiking basket cells (Glickfeld et al, 2008;Torborg et al, 2010), unlike our finding in the PC that feedforward inhibition is dendritic. The latter architecture is a consequence of the unusual laminar structure of the PC, whereby afferent inputs are received exclusively on the distal apical dendritic tufts of layer II/III principal cells.…”

Section: Functional Significancecontrasting

confidence: 99%

“…The fMP cell is reminiscent of fast-spiking basket cells found in the hippocampus and neocortex (Freund and Katona, 2007) and, like them, has a profuse axonal arbor that appears to contact the somata of many principal neurons (Yoshimura and Callaway, 2005;Glickfeld et al, 2008;Suzuki and Bekkers, 2010b). This ability of fMP cells to provide powerful perisomatic inhibition of many principal neurons suggests that they may underlie the global inhibition that has been reported in the PC (Poo and Isaacson, 2009; but see also Zhan and Luo, 2010).…”

Section: Functional Significancementioning

confidence: 91%

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Microcircuits Mediating Feedforward and Feedback Synaptic Inhibition in the Piriform Cortex

Suzuki¹,

Bekkers²

2012

J. Neurosci.

109

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Local inhibition by GABA-releasing neurons is important for the operation of sensory cortices, but the details of these inhibitory circuits remain unclear. We addressed this question in the olfactory system by making targeted recordings from identified classes of inhibitory and glutamatergic neurons in the piriform cortex (PC) of mice. First, we looked for feedforward synaptic inhibition provided by interneurons located in the outermost layer of the PC, layer Ia, which is the unique recipient of afferent fibers from the olfactory bulb. We found two types of feedforward inhibition: a fast-rising, spatially restricted kind that was generated by horizontal cells, and a slow-rising, more diffuse kind generated by neurogliaform cells. Both cell types targeted the distal apical dendrites of layer II principal neurons. Next, we studied feedback synaptic inhibition in isolation by making a tissue cut across layer I to selectively remove feedforward inhibitory connections. We identified a powerful type of feedback inhibition of layer II neurons, mostly generated by soma-targeting fast-spiking multipolar cells in layer III, which in turn were driven by feedforward excitation from layer II semilunar cells. Dynamic clamp simulation of feedback inhibition revealed differential effects of this inhibition on the two main types of layer II principal neurons. Thus, our results articulate the connectivity and functions of two important classes of inhibitory microcircuits in the PC. Feedforward and feedback inhibition generated by these circuits is likely to be required for the operation of this sensory paleocortex during the processing of olfactory information.

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Section: Functional Significancecontrasting

confidence: 99%

Section: Functional Significancementioning

confidence: 91%

Microcircuits Mediating Feedforward and Feedback Synaptic Inhibition in the Piriform Cortex

Suzuki¹,

Bekkers²

2012

J. Neurosci.

109

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“…dorsoventral axis of the MEC. To test this hypothesis, we investigated the modulation of GABA release by mu-opioid receptors (mOR), which are known to negatively regulate release from axon terminals of PV+ interneurons(Krook-Magnuson et al, 2011;Glickfeld et al, 2008). Bath application of [D-Ala 2 , NMe-Phe 4 , Gly-ol 5 ]-enkephalin (DAMGO), a canonical agonist of mORs(Figure 5A), significantly depressed evoked synaptic inhibitory currents (eIPSCs) at L2S in the MEC (Baseline: 165.1 ± 25.17 pA; in DAMGO: 46.66 ± 10.49 pA, n = 20; p < 0.01, Mann-Whitney test;…”

mentioning

confidence: 99%

Inhibitory Gradient along the Dorsoventral Axis in the Medial Entorhinal Cortex

Beed

Gundlfinger

Schneiderbauer

et al. 2013

Neuron

106

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Local inhibitory microcircuits in the medial entorhinal cortex (MEC) and their role in network activity are little investigated. Using a combination of electrophysiological, optical, and morphological circuit analysis tools, we find that layer II stellate cells are embedded in a dense local inhibitory microcircuit. Specifically, we report a gradient of inhibitory inputs along the dorsoventral axis of the MEC, with the majority of this local inhibition arising from parvalbumin positive (PV+) interneurons. Finally, the gradient of PV+ fibers is accompanied by a gradient in the power of extracellular network oscillations in the gamma range, measured both in vitro and in vivo. The reported differences in the inhibitory microcircuitry in layer II of the MEC may therefore have a profound functional impact on the computational working principles at different locations of the entorhinal network and influence the input pathways to the hippocampus.

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“…109,110 Exogenous and endogenous cannabinoid agonists inhibit the GABA A , but not GABA B , receptor-dependent inhibition of pyramidal postsynaptic currents. 110,111 Therefore, GABA released from the cholecystokinin (CCK)-expressing GABAergic interneurons (that contain CB 1 receptors) selectively activates GABA A receptors in the pyramidal neurons and the inhibition of this process by CB 1 receptor agonists results in cognitive disruption.…”

Section: Evidence For a 1 -Cb 1 Interactionsmentioning

confidence: 99%

Caffeine and Adenosine Receptor Modulation of Cannabinoid Influence Upon Cognitive Function

Sousa

Ribeiro

Sebastião

2013

Journal of Caffeine Research

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A 1 and CB 1 receptors are main targets for the cognitive effects of caffeine and D 9 -tetrahydrocannabinol (THC), two of the most heavily consumed psychoactive substances worldwide. Both receptors can coincide in the same neuronal structures and both couple to similar G proteins and transducing pathways. Ex vivo evidence revealed that A 1 and CB 1 receptors can interact, and recent in vivo studies showed that those interactions can influence the behavioral actions of cannabinoids. In particular, studies on interactions between the adenosine receptor nonselective antagonist caffeine and CB 1 receptor agonists, such as THC, showed that these receptor interactions may have relevant consequences for the function of the hippocampus, which impact upon cognition. In addition, interactions between adenosine A 2A receptors, also targeted by caffeine, and CB 1 receptors may impact upon the motor and addictive actions of cannabinoids. Being so widely consumed, caffeine habits should therefore be taken into account whenever evaluating the influences of cannabinoids upon neuronal function or dysfunction in humans. Manipulation of the degree of activation of adenosine receptors with caffeine or adenosine receptor selective ligands should also be considered to reduce side effects of CB 1 receptor ligands with therapeutic potential.

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Complementary Modulation of Somatic Inhibition by Opioids and Cannabinoids

Cited by 81 publications

References 47 publications

Microcircuits Mediating Feedforward and Feedback Synaptic Inhibition in the Piriform Cortex

Microcircuits Mediating Feedforward and Feedback Synaptic Inhibition in the Piriform Cortex

Inhibitory Gradient along the Dorsoventral Axis in the Medial Entorhinal Cortex

Caffeine and Adenosine Receptor Modulation of Cannabinoid Influence Upon Cognitive Function

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