2008
DOI: 10.1101/lm.1120509
|View full text |Cite
|
Sign up to set email alerts
|

Complementary roles for amygdala and periaqueductal gray in temporal-difference fear learning

Abstract: Pavlovian fear conditioning is not a unitary process. At the neurobiological level multiple brain regions and neurotransmitters contribute to fear learning. At the behavioral level many variables contribute to fear learning including the physical salience of the events being learned about, the direction and magnitude of predictive error, and the rate at which these are learned about. These experiments used a serial compound conditioning design to determine the roles of basolateral amygdala (BLA) NMDA receptors… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

5
41
0
1

Year Published

2011
2011
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 42 publications
(47 citation statements)
references
References 35 publications
5
41
0
1
Order By: Relevance
“…5B). Taken together, these results are consistent with previous suggestions that the amygdala is exclusively involved in learning from increases in aversive outcomes, whereas the striatum and PAG also partake in learning from decreases in aversive outcomes (21,23,29).…”
Section: Resultssupporting
confidence: 92%
See 1 more Smart Citation
“…5B). Taken together, these results are consistent with previous suggestions that the amygdala is exclusively involved in learning from increases in aversive outcomes, whereas the striatum and PAG also partake in learning from decreases in aversive outcomes (21,23,29).…”
Section: Resultssupporting
confidence: 92%
“…A large body of animal and human work implicates the amygdala and periaqueductal gray (PAG) in learning from aversive outcomes and, in particular, in generating aversive prediction errors (19)(20)(21)(22)(23)(24). BOLD responses to outcomes in these areas suggests both areas were involved in learning in our task, albeit in different ways.…”
Section: Resultsmentioning
confidence: 98%
“…There are several reports showing that NR2B antagonists decrease fear memory after both systemic and local amygdala treatments (Rodrigues et al, 2001;Zhao et al, 2005;Cole and McNally, 2008;Mathur et al, 2009). In these studies, treatments were performed in the acquisition phase of the conditioned fear test, that is, NR2B blockade interfered with learning, a process in which NMDA receptors are also involved.…”
Section: Discussionmentioning
confidence: 99%
“…Behavioral studies also suggest that the NR2B subunit mediates the PTSD-related roles of NMDA receptors. When injected before electric shocks, NR2B antagonists reduce or even abolish contextual or cue-induced freezing, showing that the NR2B subunitcontaining NMDA receptors play an important role in fear learning (Zhao et al, 2005;Cole and McNally, 2008;Mathur et al, 2009). Local treatments in the amygdala and prefrontal cortex, that is, brain regions that are strongly involved in the emotional control and highly express the NR2B subunit, also impaired the acquisition of conditioned fear (Zhao et al, 2005;Cole andMcNally, 2008, Zhang et al, 2008).…”
Section: Introductionmentioning
confidence: 92%
See 1 more Smart Citation