Complementary roles of serotonergic and cholinergic systems in decisions about when to act

Khalighinejad, Nima; Manohar, Sanjay; Rushworth, Matthew F. S.

doi:10.1016/j.cub.2022.01.042

Cited by 19 publications

(32 citation statements)

References 44 publications

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“…The representation of the environment borne by the dACC is different to that found beyond the cortex, for example, in brainstem regions such as the DRN. DRN activity reflects very broad aspects of the environment, such as whether it is good or bad and what its average value might be (Cohen et al, 2015;Hayashi et al, 2015;Khalighinejad et al, 2022;Wittmann et al, 2020). A dACC-possessing animal can represent the distribution of opportunities across its environment and not just its mean value and prediction errors about that mean.…”

Section: Llmentioning

confidence: 99%

“…Our picture of how these regions interact with one another and the dACC is currently changing rapidly (Joshi and Gold, 2022;Joshi et al, 2016;Muller et al, 2019;Soltani and Izquierdo, 2019;Tervo et al, 2014), but there is much that we still do not know. Perhaps most critically, we do not know why they interact, whether they encode identical indices of uncertainty, whether they have similar influences on behavior, and how they compare with influences from other neuromodulatory systems (Danielmeier et al, 2015;Fischer et al, 2015;Khalighinejad et al, 2020aKhalighinejad et al, , 2022.…”

Section: Dacc and Information Seekingmentioning

confidence: 99%

“…In zebrafish, however, this pattern of reward-guided decision-making depends on the dorsal raphe nucleus (DRN) (Marques et al, 2020). In rodents and even in primates, DRN activity also tracks aspects of the reward environment and indicates when behavioral change might be necessary (Grossman et al, 2022;Hayashi et al, 2015;Khalighinejad et al, 2022;Wittmann et al, 2020). Neurons in other subcortical nuclei, for example, midbrain DA neurons, also have activity that reflects the value of potential choices and the process of decision-making Yun et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Medial and orbital frontal cortex in decision-making and flexible behavior

Klein-Flügge

Bongioanni

Rushworth

2022

Neuron

Self Cite

113

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Section: Llmentioning

confidence: 99%

Section: Dacc and Information Seekingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Medial and orbital frontal cortex in decision-making and flexible behavior

Klein-Flügge

Bongioanni

Rushworth

2022

Neuron

Self Cite

113

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“…Thus, not only did monkeys put more effort to get a reward under fluoxetine ( Meyniel et al, 2016 ), but they also better used reward information in order to guide their behavior. This parameter also influenced their reaction times (RT), for it have recently been found to be prolonged in the context of decision-making under SSRIs ( Khalighinejad et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity

Gacoin

Hamed

2023

Front. Pharmacol.

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Selective serotonin reuptake inhibitors (SSRIs) increase serotonin activity in the brain. While they are mostly known for their antidepressant properties, they have been shown to improve visual functions in amblyopia and impact cognitive functions ranging from attention to motivation and sensitivity to reward. Yet, a clear understanding of the specific action of serotonin to each of bottom-up sensory and top-down cognitive control components and their interaction is still missing. To address this question, we characterize, in two adult male macaques, the behavioral effects of fluoxetine, a specific SSRI, on visual perception under varying bottom-up (luminosity, distractors) and top-down (uncertainty, reward biases) constraints while they are performing three different visual tasks. We first manipulate target luminosity in a visual detection task, and we show that fluoxetine degrades luminance perceptual thresholds. We then use a target detection task in the presence of spatial distractors, and we show that under fluoxetine, monkeys display both more liberal responses as well as a degraded perceptual spatial resolution. In a last target selection task, involving free choice in the presence of reward biases, we show that monkeys display an increased sensitivity to reward outcome under fluoxetine. In addition, we report that monkeys produce, under fluoxetine, more trials and less aborts, increased pupil size, shorter blink durations, as well as task-dependent changes in reaction times. Overall, while low level vision appears to be degraded by fluoxetine, performances in the visual tasks are maintained under fluoxetine due to enhanced top-down control based on task outcome and reward maximization.

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“…Reaction times (RT) are modulated by multiple cognitive functions ranging from spatial attention (Wardak et al, 2012a, 2011), to temporal expectation and anticipation (Cravo et al, 2013; Wardak et al, 2012b), decision making (Fujimoto et al, 2021; Hanks et al, 2006; Noorani and Carpenter, 2016), perception (Song et al, 2008), reinforcement learning (Viejo et al, 2018), arousal (Davranche et al, 2006; Eason et al, 1969; Fujimoto et al, 2021) and reward processing (Epstein et al, 2011; Firestone and Douglas, 1975; Procyk et al, 2000; Simen et al, 2009). RTs have recently been found to be prolonged in the context of decision-making under SSRIs (Khalighinejad et al, 2022). We here reproduce this observation (prolonged RTs under fluoxetine) in a detection task under spatial uncertainty as well as in a task involving free choice based on reward incentives.…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity

Gacoin

Hamed

2022

Preprint

View full text Add to dashboard Cite

Selective serotonin reuptake inhibitors (SSRIs) increase serotonin activity in the brain. While they are mostly known for their antidepressant properties, they have been shown to improve visual functions in amblyopia and impact cognitive functions ranging from attention to motivation and sensitivity to reward. Yet, a clear understanding of the specific action of serotonin to each of bottom-up sensory and top-down cognitive control components and their interaction is still missing. To address this question, we characterize, in two adult macaques, the behavioral effects of fluoxetine, a specific SSRI, on visual perception under varying bottom-up (luminosity, distractors) and top-down (uncertainty, reward biases) constraints while they are performing three different visual tasks. We first manipulate target luminosity in a visual detection task, and we show that fluoxetine degrades luminance perceptual thresholds. We then use a target detection task in the presence of spatial distractors, and we show that under fluoxetine, monkeys display both more liberal responses as well as a degraded perceptual spatial resolution. In a last target selection task, involving free choice in the presence of reward biases, we show that monkeys display an increased sensitivity to reward outcome under fluoxetine. In addition, we report that monkeys produce, under fluoxetine, more trials and less aborts, increased pupil size, shorter blink durations, as well as task-dependent changes in reaction times. Overall, while low level vision appears to be degraded by fluoxetine, performance in the visual tasks are maintained under fluoxetine due to enhanced top-down control based on task outcome and reward maximization.

show abstract

Complementary roles of serotonergic and cholinergic systems in decisions about when to act

Cited by 19 publications

References 44 publications

Medial and orbital frontal cortex in decision-making and flexible behavior

Medial and orbital frontal cortex in decision-making and flexible behavior

Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity

Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity

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