Complete and irreversible unilateral vestibular loss: A novel rat model of vestibular pathology

Péricat, David; Farina, Anne; Agavnian-Couquiaud, Emilie; Chabbert, Christian; Tighilet, Brahim

doi:10.1016/j.jneumeth.2017.04.001

Cited by 37 publications

(90 citation statements)

References 44 publications

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“…All operations were performed on left ears. Access to the vestibular nerve was achieved through the tympanic bulla approach [ 6 ]. After shaving the area of interest, animals were positioned on the ¾ back (half the way between lateral and dorsal decubitus).…”

Section: Methodsmentioning

confidence: 99%

“…Sudden alteration of the sensory inputs arising from peripheral vestibular sensory and/or neural elements evokes typical vestibular symptoms characterized by a cascade of functional disorders that includes postural imbalance at rest and during movement, spontaneous nystagmus and oscillopsia, associated to cognitive and neurovegetative disorders. These vestibular disorders occur through alteration of the vestibulo spinal, vestibulo oculomotor, vestibulo cerebellar and cortical reflexes [ 3 , 4 , 5 , 6 ] ( Fig 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…Given this anatomical-functional organization of the vestibular system and its projection targets, unilateral vestibular nerve section induces a quadruple syndrome: posture-locomotor (blue), oculomotor (green), vegetative (pink) and perceptive-cognitive (red). Adapted from [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Adjustment of the dynamic weight distribution as a sensitive parameter for diagnosis of postural alteration in a rodent model of vestibular deficit

et al. 2017

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Vestibular disorders, by inducing significant posturo-locomotor and cognitive disorders, can significantly impair the most basic tasks of everyday life. Their precise diagnosis is essential to implement appropriate therapeutic countermeasures. Monitoring their evolution is also very important to validate or, on the contrary, to adapt the undertaken therapeutic actions. To date, the diagnosis methods of posturo-locomotor impairments are restricted to examinations that most often lack sensitivity and precision. In the present work we studied the alterations of the dynamic weight distribution in a rodent model of sudden and complete unilateral vestibular loss. We used a system of force sensors connected to a data analysis system to quantify in real time and in an automated way the weight bearing of the animal on the ground. We show here that sudden, unilateral, complete and permanent loss of the vestibular inputs causes a severe alteration of the dynamic ground weight distribution of vestibulo lesioned rodents. Characteristics of alterations in the dynamic weight distribution vary over time and follow the sequence of appearance and disappearance of the various symptoms that compose the vestibular syndrome. This study reveals for the first time that dynamic weight bearing is a very sensitive parameter for evaluating posturo-locomotor function impairment. Associated with more classical vestibular examinations, this paradigm can considerably enrich the methods for assessing and monitoring vestibular disorders. Systematic application of this type of evaluation to the dizzy or unstable patient could improve the detection of vestibular deficits and allow predicting better their impact on posture and walk. Thus it could also allow a better follow-up of the therapeutic approaches for rehabilitating gait and balance.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adjustment of the dynamic weight distribution as a sensitive parameter for diagnosis of postural alteration in a rodent model of vestibular deficit

et al. 2017

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“…Vestibular nucleus (VN) is the core neural complex which receives input primarily from the peripheral vestibular organ as well as other different body structures, and the obtained messages are processed and converged in VN. As two labyrinths are separately positioned at both sides of the head, the generated vestibular information from the ipsilateral labyrinth initially projects on the ipsilateral VN, and it is again transferred to the contralateral VN through the interconnected commissural pathway (CP) [1][2][3][4][5]. Thus, if a unilateral vestibular loss occurs, the VN fails to receive the incoming sensation of head movement, and it results in imbalanced vestibular functions, such as balance control, head orientation, and navigation [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Directional preference of otolith-related neurons in vestibular nucleus

Nguyen

Kim

2020

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Background: Due to the paired structure of two labyrinths, their neural communication is conducted through the interconnected commissural pathway. Using the tight link, the neural responding characteristics are formed in vestibular nucleus, and these responses are initially generated by the mechanical movement of the hair cells in the semicircular canals and otoliths. Although the mechanism to describe the neuronal responses to the head movements was evident, few direct experimental data were provided, especially the directional preference of otolith-related neurons as one of critical responses to elucidate the function of the neurons in vestibular nucleus (VN). Experimental Approach: The directional preference of otolith-related neurons was investigated in VN. Also, a chemically induced unilateral labyrinthectomy (UL) was performed to identify the origin of the directional preference. For the model evaluation, static and dynamic behavioral tests were performed. Following the evaluation, an extracellular neural activity was recorded for the neuronal responses to the horizontal head rotation and the linear head translation. Results: Seventy seven neuronal activities were recorded from thirty SD rats (270-450 g, male), and total population was divided into three groups; left UL (20), sham (35), right UL (22). Based on the directional preference, two sub-groups were again classified as contra- and ipsi-preferred neurons. There was no significance in the number of those sub-groups (contra-: 15/35, 43%; ipsi-: 20/35, 57%) in the sham (p=0.155). However, more ipsi-preferred neurons (19/22, 86%) were observed after right UL (p=6.056×10-5) while left UL caused more contra-preferred neurons (13/20, 65%) (p=0.058). In particular, the convergent neurons mainly led this biased difference in the population (ipsi-: 100% after right UL & contra-: 89% after left UL) (p<0.002). Conclusion: The directional preference was evenly maintained under a normal vestibular function, and its unilateral loss biased the directional preference of the neurons, depending on the side of lesion. Moreover, the dominance of the directional preference was mainly led by the convergent neurons which had the neural information related with head rotation and linear translation.

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“…the head, the generated neural signal initially projects on the ipsilateral VN, and it is again transferred to the contralateral VN through the interconnected commissural pathway (CP) [1][2][3][4][5]. Thus, if a unilateral vestibular loss occurs, the same side of VNs fails to receive the incoming sensation of head movement, and it results in imbalanced vestibular functions, such as balance control, head orientation, and navigation [6][7][8].…”

mentioning

confidence: 99%

Directional preference of otolith-related neurons in vestibular nucleus

Nguyen

Kim

2020

Preprint

View full text Add to dashboard Cite

Background: Due to the paired structure of two labyrinths at both sides of ear, their communication is conducted through the interconnected commissural pathway. The close interconnection produces the neural responding property in vestibular nucleus, and the mechanical movement of the hair cells mainly specifies the property. However, the mechanism to initiate the responding property was evident based on the structure, but few direct experimental data were provided to understand the responding property based on the structure.Experimental Approach: The directional preference was investigated, which was one of critical neural responding property to illustrate the functional structure. Also, a chemically induced unilateral labyrinthectomy (UL) was performed to emphasize the preference. For the model evaluation, static and dynamic behavioral tests were applied, and the results demonstrated a practical model construction. Following the evaluation, an extracellular neural activity was conducted for the neuronal responses to the horizontal head rotation and the linear head movement.Results: Seventy seven neuronal activities were recorded from thirty SD rats (270-450 g, male), and total population was divided into three groups; left UL (20), sham (35), right UL (22). Based on the directional preference, two sub-groups were again classified as contra- and ipsi-preferred neurons. There was no significance between those sub-groups (contra-: 15/35, 43%; ipsi-: 20/35, 57%) in sham model. However, more ipsi-preferred neurons (19/22, 86%) were observed after right UL while left UL caused more contra-preferred neurons (13/20, 65%). In particular, the convergent neurons mainly led this biased difference in the population (ipsi-: 100% after right UL & contra-: 89% after left UL).Conclusion: The directional preference was evenly maintained under a normal vestibular function, and its unilateral loss biased the directional preference of the neurons, depending on the side of lesion. Moreover, the dominance of the directional preference was mainly led by the convergent neurons which had the neural information related with head rotation and linear translation.

show abstract

Complete and irreversible unilateral vestibular loss: A novel rat model of vestibular pathology

Cited by 37 publications

References 44 publications

Adjustment of the dynamic weight distribution as a sensitive parameter for diagnosis of postural alteration in a rodent model of vestibular deficit

Adjustment of the dynamic weight distribution as a sensitive parameter for diagnosis of postural alteration in a rodent model of vestibular deficit

Directional preference of otolith-related neurons in vestibular nucleus

Directional preference of otolith-related neurons in vestibular nucleus

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