This communication presents an analytical framework that combines transmission line models for the design of electromagnetically coupled microstrip patch antennas for the 2.45 GHz industrial, scientific and medical band. It provides initial values for all dimensions of the antenna, with measured resonance frequency errors below 6%. The initial design is optimized in two subsequent phases to center the resonance frequency and to increase the impedance bandwidth (BW), obtaining measured resonance frequency errors below 0.6% and BW enhancements of more than 1.2 times the original ones, respectively. The model has been validated with antenna prototypes based on rigid and textile materials, exhibiting excellent freespace measured BW of 4% and 5.12%, maximal measured gains of 4.28 dBi and 7.33 dBi, and radiation efficiencies of 63.4% and 71.8%, respectively. Moreover, very stable on-body performance is obtained, with minimal frequency detuning when deploying the textile antenna on the human body. The measured maximum onbody gain for the textile antenna equals 5.5 dBi, with a simulated specific absorption rate of 0.323 W/kg at 2.45 GHz.