Complete atrioventricular block in a woman with systemic lupus erythematosus

Gómez-Barrado, José J.; Garcı́a-Rubira, Juan C.; Ostariz, Miguel Ángel Polo; Albarrán, Soledad Turégano

doi:10.1016/s0167-5273(01)00590-3

Cited by 12 publications

(7 citation statements)

References 7 publications

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“…Finally, we could not completely rule out the possibility of leukemic infiltration of the myocardium or cardiac toxicity caused by chemotherapeutic agents. Infiltrative cardiomyopathy, caused by tumors or autoimmune diseases, may result in complete heart block [7,8]. In this case, complete heart block occurred and disappeared simultaneously with ST-T changes in ECG.…”

Section: Discussionmentioning

confidence: 72%

Recurrent coronary spasm with complete atrioventricular block in a patient with refractory acute myelocytic leukemia

Lin

Chow

Hsieh

et al. 2005

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 72%

Recurrent coronary spasm with complete atrioventricular block in a patient with refractory acute myelocytic leukemia

Lin

Chow

Hsieh

et al. 2005

International Journal of Cardiology

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“…In the study of Godeau et al., two out of five patients had prior myocarditis, possibly diagnosed on the basis of impaired systolic function. 6 In addition, a few case reports have described concomitant lupus cardiomyopathy and cAVB that was managed with pacemaker 22 or ventricular fibrillation managed conservatively. 23 In our series, two patients had a history of lupus myocarditis, 9 years and 16 years before PPM implantation.…”

Section: Discussionmentioning

confidence: 99%

Severe brady-arrhythmias in systemic lupus erythematosus: prevalence, etiology and associated factors

Tselios

Gladman

Harvey

et al. 2018

Lupus

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Background Severe brady-arrhythmias, requiring a permanent pacemaker (PPM), have been sparsely reported in systemic lupus erythematosus (SLE). The aim of this study was to describe the characteristics of such arrhythmias in a defined lupus cohort. Patients and methods The database of the Toronto Lupus Clinic ( n = 1366) was searched for patients who received a PPM. Demographic, clinical, immunological and therapeutic variables along with electrocardiographic (ECG) and echocardiographic findings (based on the last available test prior to PPM) were analyzed. Patients with a PPM (cases) were compared with age-, sex- and disease duration-matched patients without a PPM (controls). Analysis was performed with SAS 9.0; p < 0.05 was considered significant. Results Eighteen patients were identified, 13 (0.95%) with complete atrioventricular block and 5 (0.37%) with sick sinus syndrome. Disease duration at PPM implantation was 22 ± 12 years. Compared to controls, cases had more frequently coronary artery disease, hypertension, dyslipidemia and longer antimalarial (AM) treatment duration. The prevalence of first-degree atrioventricular block, right bundle branch block, left anterior fascicular block and septal hypertrophy was also higher. AM treatment was significantly associated with brady-arrhythmias (OR = 1.128, 95% CI = 1.003-1.267, p = 0.044). Nine patients had prior heart disease and one received a PPM two years after renal transplantation. Eight patients did not have any potential risk factors; prolonged AM therapy (mean 22 years) might have been the cause. Conclusions Apart from known causes, prolonged AM treatment may be associated with severe brady-arrhythmias in SLE. Certain ECG and echocardiographic characteristics may represent indicators of an ongoing damage in the conduction system.

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“…Arrhythmias are uncommon but heart block has been reported in systemic lupus erythematosus. 6 Small vessel vasculitides include Wegener's granulomatosis, microscopic polyarteritis, and Churg-Strauss syndrome. They are usually associated with the presence of antineutrophil cytoplasmic antibodies, though this may be negative.…”

Section: Discussionmentioning

confidence: 99%