Complete atrioventricular block persisting after regression of infectious myocarditis

Chilon, T.; Dumonteil, Nicolas; Fontán, A

doi:10.1016/j.jelectrocard.2008.07.001

Cited by 11 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recent discovery that macrophages contribute to AVN conduction could also be useful for treating arrhythmias and conduction abnormalities that result from inflammation of the heart. The inflammatory diseases lyme carditis, viral myocarditis, and cardiac sarcoidosis have all been associated with cardiac conduction abnormalities [ 151 , 152 , 153 ], whilst there has also been a reported case of a patient suffering from complete atrioventricular block after the regression of infectious myocarditis [ 154 ]. Macrophages also change phenotype and numbers in response to MI and HF, both of which are associated with ventricular arrhythmia and sudden cardiac death [ 126 ].…”

Section: Non-myocyte Gap Junctions and Hemichannels As Novel Theramentioning

confidence: 99%

Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?

Johnson

Camelliti

2018

IJMS

View full text Add to dashboard Cite

The heart is a complex organ composed of multiple cell types, including cardiomyocytes and different non-myocyte populations, all working closely together to determine the hearts properties and maintain normal cardiac function. Connexins are abundantly expressed proteins that form plasma membrane hemichannels and gap junctions between cells. Gap junctions are intracellular channels that allow for communication between cells, and in the heart they play a crucial role in cardiac conduction by coupling adjacent cardiomyocytes. Connexins are expressed in both cardiomyocytes and non-myocytes, including cardiac fibroblasts, endothelial cells, and macrophages. Non-myocytes are the largest population of cells in the heart, and therefore it is important to consider what roles connexins, hemichannels, and gap junctions play in these cell types. The aim of this review is to provide insight into connexin-based signalling in non-myocytes during health and disease, and highlight how targeting these proteins could lead to the development of novel therapies. We conclude that connexins in non-myocytes contribute to arrhythmias and adverse ventricular remodelling following myocardial infarction, and are associated with the initiation and development of atherosclerosis. Therefore, therapeutic interventions targeting these connexins represent an exciting new research avenue with great potential.

show abstract

Section: Non-myocyte Gap Junctions and Hemichannels As Novel Theramentioning

confidence: 99%

Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?

Johnson

Camelliti

2018

IJMS

View full text Add to dashboard Cite

show abstract

“…Most of the acquired atrioventricular block after acute myocarditis is expected to recover after the inflammation is resolved. [1][2][3][4] Thus, most of such children will have complete recovery. A review of the literature showed that the recovery time of complete atrioventricular block may range from few days to weeks, with the longest of 18 days.…”

Section: Discussionmentioning

confidence: 99%

Late recurrence of infra-Hisian complete atrioventricular block

Chang

Wang

2011

Cardiol Young

View full text Add to dashboard Cite

Acquired complete atrioventricular block that is caused by infectious myocarditis is usually transient and has a favourable outcome. We report the case of a 15-year-old girl who had complete infra-Hisian atrioventricular block due to adeno viral myocarditis and received a permanent pacemaker at the age of 10 months. The pacemaker lost its function at the age of 7 years. However, she experienced a late recurrence of complete atrioventricular block 10 years later. Complete atrioventricular block is rarely recovered if it persisted for 2 weeks. Even in the patients with late recovery, long-term follow-up and pacemaker therapy are still needed.

show abstract

“…Immunosuppressive therapy with steroids can promote recovery of atrioventricular nodal conduction. In some patients, however, complete atrioventricular blocks may persist even after the acute phase, requiring permanent pacemaker implantation [213]. Resynchronization therapy and the application of mechanical pumps enable longer survival of patients with severe DCM.…”

Section: Hemodynamically Unstable Patientsmentioning

confidence: 99%

Update on Myocarditis: From Etiology and Clinical Picture to Modern Diagnostics and Methods of Treatment

Lasica,

Djukanovic,

Savic

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Although the frequency of myocarditis in the general population is very difficult to accurately determine due to the large number of asymptomatic cases, the incidence of this disease is increasing significantly due to better defined criteria for diagnosis and the development of modern diagnostic methods. The multitude of different etiological factors, the diversity of the clinical picture, and the variability of the diagnostic findings make this disease often demanding both for the selection of the diagnostic modality and for the proper therapeutic approach. The previously known most common viral etiology of this disease is today overshadowed by new findings based on immune-mediated processes, associated with diseases that in their natural course can lead to myocardial involvement, as well as the iatrogenic cause of myocarditis, which is due to use of immune checkpoint inhibitors in the treatment of cancer patients. Suspecting that a patient with polymorphic and non-specific clinical signs and symptoms, such as changes in ECG and echocardiography readings, has myocarditis is the starting point in the diagnostic algorithm. Cardio magnetic resonance imaging is non-invasive and is the gold standard for diagnosis and clinical follow-up of these patients. Endomyocardial biopsy as an invasive method is the diagnostic choice in life-threatening cases with suspicion of fulminant myocarditis where the diagnosis has not yet established or there is no adequate response to the applied therapeutic regimen. The treatment of myocarditis is increasingly demanding and includes conservative methods of treating heart failure, immunomodulatory and immunospressive therapy, methods of mechanical circulatory support, and heart transplantation. The goal of developing new diagnostic and therapeutic methods is to reduce mortality from this complex disease, which is still high.

show abstract

Complete atrioventricular block persisting after regression of infectious myocarditis

Cited by 11 publications

References 5 publications

Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?

Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?

Late recurrence of infra-Hisian complete atrioventricular block

Update on Myocarditis: From Etiology and Clinical Picture to Modern Diagnostics and Methods of Treatment

Contact Info

Product

Resources

About