Complete Blood Cell Counts in Capillary and Venous Blood of Healthy Term Newborns

Özbek, Namık; Gürakan, Berkan; Kayıran, Sinan Mahir

doi:10.1159/000041056

Cited by 30 publications

(20 citation statements)

References 4 publications

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“…, 1991; Christensen, 2000). However, in an earlier study, we showed that CBCs done on blood from different sources (venous or capillary) in full‐term, healthy newborns yield different findings (Özbek, Gürakan & Kayıran, 2000). In the current study, we investigated a large range of blood parameters in venous blood from SGA and AGA neonates.…”

Section: Discussionmentioning

confidence: 92%

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

et al. 2006

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No previous study has investigated the full range of complete blood count (CBC) parameters in small-for-gestational-age (SGA) newborns. The main aim of this study was to compare CBC and peripheral smear parameters in term, healthy SGA neonates and appropriate-for-gestational-age (AGA) neonates, and to establish CBC reference values for full-term SGA newborns. One hundred thirty-two healthy, term newborns (73 SGA and 59 AGA) were included. On day 1, we obtained 109 samples and on day 7 we obtained 77 samples. A CBC and peripheral smear were analyzed for each sample collected and group data were compared. We observed higher mean values for normoblast count, hemoglobin, hematocrit, and red blood cell (RBC) count in the SGA babies than in the AGA babies on day 1. The mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration values for the SGA babies were decreased because of the relatively high RBC count and relatively high mean corpuscular volume we observed in this group. Of the SGA newborns, 21.9% had neutropenia and 4.7% had absolute neutrophil counts lower than 1500/microl on day 1. On both day 1 and day 7, the SGA newborns had higher mean absolute metamyelocyte counts and higher mean I : T (immature : total neutrophil ratio) values than the AGA group. The SGA babies had a lower mean absolute lymphocyte count on day 7 than the AGA group. We detected thrombocytopenia in almost one-third of the 64 SGA newborns tested on day 1. In summary, our study clearly demonstrates that CBC parameters for healthy, full-term, SGA newborns are different from those of healthy, term AGA newborns. This is the first study that has documented different mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, metamyelocyte counts, lymphocyte counts, and I : T in SGA babies compared with AGA babies.

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Section: Discussionmentioning

confidence: 92%

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

et al. 2006

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“…This relation did fall within the 95%-confidence interval of the relation previously found by Varela et al; R 1b = 0.5 × Hct + 0.37 (Varela et al, 2011). We know that the haematocrit is by itself susceptible to noise as posture (Jacob et al, 2005), punctuate location and sample (arterial-drawn, capillary-drawn or venous-drawn sample) (Kayiran et al, 2003; Ozbek et al, 2000) can influence its results. Therefore, we subdivided the samples into arterial-drawn and capillary-drawn and interestingly enough we discovered a strong relation with arterial-drawn haematocrit ( R 2 = 0.711, p < 0.01) but a weak and nonsignificant relation between capillary-drawn haematocrit and T 1b .…”

Section: Discussionmentioning

confidence: 99%

Impact of neonate haematocrit variability on the longitudinal relaxation time of blood: Implications for arterial spin labelling MRI

Vis¹,

Hendrikse²,

Groenendaal³

et al. 2014

NeuroImage: Clinical

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Background and purposeThe longitudinal relaxation time of blood (T1b) is influenced by haematocrit (Hct) which is known to vary in neonates. The purpose of this study was threefold: to obtain T1b values in neonates, to investigate how the T1b influences quantitative arterial spin labelling (ASL), and to evaluate if known relationships between T1b and haematocrit (Hct) hold true when Hct is measured by means of a point-of-care device.Materials and methodsOne hundred and four neonates with 120 MR scan sessions (3 T) were included. The T1b was obtained from a T1 inversion recovery sequence. T1b-induced changes in ASL cerebral blood flow estimates were evaluated. The Hct was obtained by means of a point-of-care device. Linear regression analysis was used to investigate the relation between Hct and MRI-derived R1 of blood (the inverse of the T1b).ResultsMean T1b was 1.85 s (sd 0.2 s). The mean T1b in preterm neonates was 1.77 s, 1.89 s in preterm neonates scanned at term-equivalent age (TEA) and 1.81 s in diseased neonates. The T1b in the TEA was significantly different from the T1b in the preterm (p < 0.05). The change in perfusion induced by the T1b was −11% (sd 9.1%, p < 0.001). The relation between arterial-drawn Hct and R1b was R1b = 0.80 × Hct + 0.22, which falls within the confidence interval of the previously established relationships, whereas capillary-drawn Hct did not correlate with R1b.ConclusionWe demonstrated a wide variability of the T1b in neonates and the implications it could have in methods relying on the actual T1b as for instance ASL. It was concluded that arterial-drawn Hct values obtained from a point-of-care device can be used to infer the T1b whereas our data did not support the use of capillary-drawn Hct for T1b correction.

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“…We have to state that the hemostatic system is at an activated state immediately after birth; that is, elevated factor V and factor VIII activities have been detected in cord plasma [18]. Furthermore, umbilical cord and neonatal venous blood differ in their blood cell counts, influencing the concentrations of citrate and both procoagulant and anticoagulant proteins in plasma [19,20].…”

Section: Discussionmentioning

confidence: 99%

Effects of melagatran on activated partial thromboplastin time and on ecarin clotting time in cord versus adult plasma

Koestenberger

Gallistl²,

Leschnik³

et al. 2006

Blood Coagulation &Amp; Fibrinolysis

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Melagatran is the active form of the oral direct thrombin inhibitor ximelagatran. Melagatran does not require antithrombin as a cofactor. Its administration is therefore of special interest in neonatal patients, whose plasma is relatively deficient in antithrombin. We investigated the effects of increasing amounts of melagatran (0.05-1 micromol/l) on the activated partial thromboplastin time (APTT) and ecarin clotting time (ECT) in cord versus adult plasma. Both the APTT and ECT were dose-dependently prolonged in the presence of increasing amounts of melagatran. Furthermore, the ECT revealed a higher susceptibility of cord plasma to addition of melagatran than adult plasma. Whereas similar amounts of melagatran were required in cord and adult plasma samples to double the APTT (IC(50), 0.47 vs 0.46 micromol/l), significantly less melagatran was required in cord versus adult plasma to double the ECT (IC(50), 0.26 vs 0.56 micromol/l). Based on APTT measurements, similar plasma levels of melagatran might be required in neonates and in adults to treat thromboembolic complications. The APTT, however, is relatively insensitive to plasma melagatran concentrations. When the sensitive indicator ECT is used, results suggest that lower amounts of melagatran might be required in neonates than in adults. This has to be scrutinized in future clinical studies.

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Complete Blood Cell Counts in Capillary and Venous Blood of Healthy Term Newborns

Cited by 30 publications

References 4 publications

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

Impact of neonate haematocrit variability on the longitudinal relaxation time of blood: Implications for arterial spin labelling MRI

Effects of melagatran on activated partial thromboplastin time and on ecarin clotting time in cord versus adult plasma

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