Complete blood count and differential in diagnosis of early onset neonatal sepsis

Ognean, Mihai; Boicean, Adrian; Șular, Floredana-Laura; Cucerea, Manuela

doi:10.1515/rrlm-2016-0042

Cited by 12 publications

(13 citation statements)

References 26 publications

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“…We believe that the significant decreases in hemoglobin and hematocrit values after G-CSF administration in our study were secondary to the frequent blood specimen collections for laboratory tests, prematurity, and other existing neonatal problems. Although sepsis, 3,13 SGA birth weight, 2 and maternal preeclampsia 19 are risk factors for thrombocytopenia in newborns, we observed no significant differences in platelet values in our study (P=0.180). A study reported that a G-CSF treatment group exhibited no change in platelet values after G-CSF administration when compared to baseline.…”

Section: Discussioncontrasting

confidence: 70%

“…1 However, the incidence of neonatal neutropenia is higher in infants who are small for gestational age (SGA), born to mothers with hypertension and/or preeclampsia, and those with sepsis. 2,3 Neutropenia is defined as having an absolute neutrophil count (ANC) below the 5 th percentile according to the reference range, or <1,000-1,500/μL. 4,5 The etiology of neutropenia includes inadequate production, excessive margination, or increased destruction of neutrophils.…”

mentioning

confidence: 99%

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White blood cell count and ratıo changes ın newborns after granulocyte colony-stımulatıng factor treatments

Buyukeran

Yiğit²,

Çelik

et al. 2021

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Background Granulocyte-colony stimulating factor (G-CSF) is frequently used to treat neonatal neutropenia. There is a paucity of data in the literature on when immature to total neutrophil ratio (I/T ratio) can be accurately used as a sepsis marker after G-CSF therapy, as well as when I/T ratio returns to normal values expected in newborns who did not receive G-CSF. Objective To investigate changes in white blood cells counts and ratios in neonates with neutropenia before and after G-CSF therapy. Methods This retrospective study included newborns admitted to the NICU of Hacettepe University Ihsan Dogramaci Hospital, Ankara, Turkey, between 2005 and 2017 who received G-CSF therapy for neutropenia. Subjects underwent complete blood counts on the day before receiving G-CSF therapy (day 0) as well as days 1, 2, and 3 after treatment; I/T ratios were recorded from peripheral smears. Results Twenty-eight neonates were included in the study. Subjects’ median gestational age (interquartile range 25–75%) was 32.6 (29.7–37.6) weeks, and median birth weight was 1,630 (1,040–2,980) g. On day 3, there were significant increases in white blood cell counts compared to day 0. There were statistically significant elevations in the I/T ratios between day 0 and day 1 and between day 0 and day 2. On day 3, the I/T ratio decreased, but was not significantly different between day 0 and day 3. Conclusion The changes in I/T ratio observed after G-CSF treatments in our study suggest that the I/T ratio can be used as a reliable sepsis marker starting 72 hours after G-CSF administration. However, I/T ratio is significantly affected within 72 hours of G-CSF administration, and therefore, is unreliable as a sepsis marker during that period.

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Section: Discussioncontrasting

confidence: 70%

mentioning

confidence: 99%

White blood cell count and ratıo changes ın newborns after granulocyte colony-stımulatıng factor treatments

Buyukeran

Yiğit²,

Çelik

et al. 2021

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“…Tam kan sayımı, evrensel olarak kullanılan, çeşitli hastalıklar için önemli takip parametreleri içeren ve karar aşamasında hekime yardımcı olan hızlı ve ucuz bir testtir 7 . Tam kan sayımı parametrelerinden olan lökosit sayısı, nötrofil sayısı ve trombosit sayısı yenidoğan sepsisi tanısında yaygın olarak kullanılan laboratuvar parametreleridir 8 . Son yıllarda, tam kan sayımı parametrelerinden olan ortalama trombosit hacmi (MPV) 9,10 , trombosit dağılım genişliği (PDW) 9,10 , eozinofil sayısı 11 , eritrosit eritrosit dağılım genişliği (RDW) 12 ve tam kan sayımına dayalı skorlardan olan nötrofil/lenfosit oranı (NLO) 1,11,13,14 ve trombosit/lenfosit oranı (TLO) 1,13 (hipotermi <36º C, hipertermi>38,5 º C, ısı düzensizliği) 6) Cilt ve cilt altı lezyonlar (peteşiyel döküntü, sklerem).…”

Section: Yenidoğanunclassified

“…Tam kan sayımı uygun maliyetli basit bir yöntemdir ve pek çok hastalık için tanı ve takip parametrelerini içerir. Günümüzde, tam kan sayımından elde edilen lökosit sayısı, trombosit sayısı ve nötrofil sayısı yenidoğan sepsisi laboratuvar tanı kriterleri arasında yer almaktadır 8 . Son yıllarda, yenidoğan sepsisinin tanısı için kolay erişilebilen ve uygun maliyetli olan tam kan sayımı parametreleri yeniden gözden geçirilmekte ve tam kan sayımı parametrelerine dayanan skorlar araştırılmaktadır 1,[9][10][11][12][13][14] .…”

Section: Yenidoğanunclassified

Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

Akkeçeci¹,

Seğmen²,

Yurttutan³

et al. 2019

Dicle Tıp Dergisi

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ÖzAmaç: Bu çalışma tam kan sayımı parametrelerinin ve tam kan sayımına dayalı skorların yenidoğan sepsisinde tanısal biyo-belirteç olarak kullanılıp kullanılamayacaklarını belirlemek amacıyla planlanmıştır.Yöntemler: Retrospektif olarak planlanan bu çalışmaya, yenidoğan sepsisi tanısı almış 70 hasta (Grup 1) ve hasta grubuyla benzer yaş, cinsiyet, doğum ağırlığı ve doğum haftasında olan 65 sağlıklı yenidoğan (Grup 2) olarak çalışmaya alındı. Demografik veriler, kan kültürü sonuçları, klinik ve laboratuvar bulguları tıbbi kayıtlardan elde edildi. Nötrofil/lenfosit oranı (NLO), trombosit/lenfosit oranı (TLO), eozinofil/lenfosit oranı (ELO), bazofil/lenfosit oranı (BLO) ve monosit/lenfosit oranı (MLO) gibi tam kan sayımına dayalı skorlar, sırasıyla nötrofil, trombosit, eozinofil, bazofil ve monosit sayısının lenfosit sayısına bölünmesiyle hesaplandı. Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

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“…6 Understandably then, there has been significant interest in identification of specific biomarkers of neonatal sepsis. 7 Haematological indices are still being the most 8 Research studies reported that PCT is an effective marker for sepsis as PCT levels rise earlier and return to normal levels more rapidly than other inflammatory markers.…”

Section: Introductionmentioning

confidence: 99%

A prospective study of inflammatory biomarkers in neonatal sepsis at a tertiary level hospital

Paimode

Sharma

Kour

2020

Int J Contemp Pediatr

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Background: Sepsis in neonates is a syndrome which is characterized clinically by systemic symptoms or signs of infection and associated with bacteremia in the first 28 days of life. More than 40% of under-five deaths globally occur in the neonatal period, resulting in 3.1 million newborn deaths each year. Procalcitonin (PCT) is an early diagnostic tool for neonatal sepsis.Methods: Present prospective cross- sectional observational study was conducted at NICU of Base hospital, Delhi Cantonment from 1st Dec 2016 to Jan 31st, 2018. Universal sampling technique was followed. SPSS version 21 was used for statistical analysis. A p-value of less than 0.05 was taken as significant.Results: Out of the total 440 cases, 63% were males while rest 37% were females. Mean gestation age and birth weight of the babies was 35.6 weeks and 2.13 Kg respectively. Raised/ decreased Total Leucocyte Count (TLC) and raised pro calcitonin levels were seen in 23% and 19.8% cases respectively.Conclusions: These results indicated that the sensitivity of procalcitonin was higher than TLC for the diagnosis of culture proven neonatal sepsis. Hence, PCT is a more sensitive and useful biomarker for the diagnosis of neonatal sepsis.

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Complete blood count and differential in diagnosis of early onset neonatal sepsis

Cited by 12 publications

References 26 publications

White blood cell count and ratıo changes ın newborns after granulocyte colony-stımulatıng factor treatments

White blood cell count and ratıo changes ın newborns after granulocyte colony-stımulatıng factor treatments

Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

A prospective study of inflammatory biomarkers in neonatal sepsis at a tertiary level hospital

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