Complete blood count profiles in children with eczema herpeticum

Chan, Grace; Wee, Choo Phei; Ong, Peck Y.

doi:10.1111/pai.13648

Cited by 3 publications

(5 citation statements)

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“…Суттєво, що зміна такого співвідношення може бути обумовлена як зниженням кількості лімфоцитів, так і підвищенням відсотка нейтрофілів у крові. Деякі автори вважають, що ступінь хоумінгу лімфоцитів у шкіру може бути дійсно достатнім, щоб викликати лімфопенію, про що свідчать випадки лімфопенії при тяжкому перебігу атопічної екземи (АД) [52,53]. Як випливає з наших даних і даних літератури, нейтрофільоз частіше зустрічається при важкій формі АД.…”

Section: обговоренняunclassified

Cord Blood as a Corrector of Hematological and Cytomorphological Characteristics of Lymphohemopoietic Organs in Experimental Atopic Dermatitis

Koval,

Bondarovych,

Goltsev

2023

Innov Biosyst Bioeng

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Background. Atopic dermatitis (AD) is an inflammatory skin disease caused by a shift in the interaction between cells of the immune system and the skin. Steroid anti-inflammatory drugs used to treat AD often lead to numerous side effects. Therefore, the development of new natural multifunctional preparations with immunomodulatory activity is of great importance. Objective. To determine the changes in indices of the leukocytes cluster of peripheral blood and determine the peculiarities of cytomorphological changes in the spleen and lymph nodes (LN) of rats with induced AD before and after administration of cryopreserved (cHCBL) and lyophilized (lHCBL) forms of human cord blood leukoconcentrate. Methods. The experiments were conducted using 6-month-old Wistar rats. AD was induced by topically applying a 5% alcohol-acetone solution of dinitrochlorobenzene (DNCB) to the skin of the rats' back for 21 days. Each form of the preparation (cHCBL and lHCBL) was administered intraperitoneally in a 0.5 ml dose containing 5´106 cells, one day after the final DNCB treatment. The following parameters were assessed in the blood: leukocyte count and the neutrophil-to-lymphocyte ratio (N/L index). Сytomorphological characteristics were determined in the spleen and inguinal LN. Results. In AD, specific changes in the cytomorphological characteristics of the lymphohematopoietic complex (LHС) structures, namely the spleen and LN, were observed alongside alterations in the leukocyte cluster indices. The most notable changes in the spleen included the dominance of the white pulp over the red pulp and the prevalence of follicles of stages II and III of development in the LN. Animals with AD displayed pronounced leukocytosis and an increased N/L index in their blood. The study demonstrates the positive corrective effects of cHCBL and lHCBL on the morphological characteristics of LHC and the specified blood parameters. Conclusions. The effectiveness of the cHCBL and lHCBL use for correcting indices of leukocytes cluster of peripheral blood and the structural organization of lymphohemopoietic organs in the development of AD have been proven.

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Section: обговоренняunclassified

Cord Blood as a Corrector of Hematological and Cytomorphological Characteristics of Lymphohemopoietic Organs in Experimental Atopic Dermatitis

Koval,

Bondarovych,

Goltsev

2023

Innov Biosyst Bioeng

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“…movement of white blood cells out of the circulating volume to the skin) as a major feature of AE 3–5 . The degree of skin homing may be sufficient to induce detectable lymphopenia on laboratory testing as is evidenced by case reports of lymphopenia in severe AE 6,7 . Lymphopenia may be a marker of increased infection risk and it complicates initiation and monitoring of currently available broad immunosuppressive systemic therapies to manage AE 8 …”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] The degree of skin homing may be sufficient to induce detectable lymphopenia on laboratory testing as is evidenced by case reports of lymphopenia in severe AE. 6,7 Lymphopenia may be a marker of increased infection risk and it complicates initiation and monitoring of currently available broad immunosuppressive systemic therapies to manage AE. 8 People with AE are known to have increased rates of cutaneous and non-cutaneous infections.…”

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confidence: 99%

The association between atopic eczema and lymphopenia: Results from a UK cohort study with replication in US survey data

Hollestein

Ky-Leigh

et al. 2023

Acad Dermatol Venereol

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Background: Lymphocyte skin homing in atopic eczema (AE) may induce lymphopenia.Objective: To determine if AE is associated with lymphopenia.Methods: We used UK primary care electronic health records (Clinical Practice Research Datalink GOLD) for a matched cohort study in adults (18yrs+) (1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015) with at least 1 recorded lymphocyte count. We matched people with AE to up to 5 people without. We used multivariable logistic regression to estimate the association between AE and lymphopenia (two low lymphocyte counts within 3 months) and linear mixed effects regression to estimate the association with absolute lymphocyte counts using all available counts. Cox proportional hazard models were used to investigate the effect of lymphopenia on common infections. We replicated the study using US survey data (National Health and Nutrition Examination Survey [NHANES]).Results: Amongst 71,731 adults with AE and 126,349 adults without AE, we found an adjusted odds ratio (OR) for lymphopenia of 1.16 (95%CI: 1.09-1.23), the strength of association increased with increasing eczema severity. When comparing all recorded lymphocyte counts from adults with AE(n=1,497,306) to those of people without AE(n=4,035,870) we saw a lower mean lymphocyte (adjusted mean difference -0.047*10 9 /L (95%CI:-0.051--0.043)) in those with AE. The difference was larger for men, increasing age, increasing AE severity and was present among people with AE not treated with immunosuppressive drugs. In NHANES (n=22,624), the adjusted OR for lymphopenia in adults with AE was 1.30 (95% CI 0.80-2.11), and the adjusted mean lymphocyte count difference was -0.03*10 9 /L (95%CI -0.07-0.02). Despite having a lower lymphocyte count, adjusting for time with lymphopenia, did not alter risk estimates of infections. Conclusion: AE, including increasing AE severity, is associated with a decreasing lymphocyte count, regardless of immunosuppressive drug use.. Whether the decreasing lymphocyte count has wider health implications for people with severe eczema warrants further investigation.

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“…Lymphopenia has been documented in atopic eczema (AE) patients mostly in the setting of an active infection 1,2 . However, the question is whether lymphopenia is a primary problem in AE leading to infection or it is a secondary problem due to infection.…”

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confidence: 99%

“…Acute lymphopenia is common with viral respiratory infections 4 . In AE patients, CBC may also be sent together with viral or bacterial identification testing during a skin infection, which may be associated with lymphopenia 1,2 . AE patients are not known to have a primary immunodeficiency that predisposes them to have increased infection.…”

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confidence: 99%