2021
DOI: 10.1007/s41981-021-00173-2
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Complete chiral resolution in a continuous flow crystallizer with recycle stream

Abstract: Repeated temperature cycling of crystals from a conglomerate forming chiral substance suspended in their saturated solution has shown to be effective in converting a mixture of both enantiomers into an enantiomerically pure state. While by now a large number of different setups has been demonstrated, here we show for the first time how a continuous flow temperature cycler with recycle stream is capable of establishing enantiopurity while converting a racemic starting suspension. By capturing the most significa… Show more

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Cited by 7 publications
(5 citation statements)
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“…42 It is therefore straightforward, based on chemical reaction engineering principles, that only for the configuration, which does not contain crystals of the undesired enantiomer (i.e., base configuration), attaining complete enantiomeric purity is feasible. Note that the only feed strategy utilized as to date in continuous tubular temperature cycles experiments is the suspension feed, 26,27 which is not the preferred feeding strategy in an MSMPR crystallizer, as it is expected to underperform the other two feed strategies. However, one could overcome the intrinsic limitation of continuous mixed flow reactors, e.g., by using a cascade of reactors.…”
Section: Process Designmentioning
confidence: 99%
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“…42 It is therefore straightforward, based on chemical reaction engineering principles, that only for the configuration, which does not contain crystals of the undesired enantiomer (i.e., base configuration), attaining complete enantiomeric purity is feasible. Note that the only feed strategy utilized as to date in continuous tubular temperature cycles experiments is the suspension feed, 26,27 which is not the preferred feeding strategy in an MSMPR crystallizer, as it is expected to underperform the other two feed strategies. However, one could overcome the intrinsic limitation of continuous mixed flow reactors, e.g., by using a cascade of reactors.…”
Section: Process Designmentioning
confidence: 99%
“…26 In a recent work, the feasibility of performing continuous temperature cycles in a continuous tubular crystallizer was demonstrated. 27 Nevertheless, to the best of our knowledge, application of periodic temperature cycles in mixed suspension mixed product removal crystallizers (MSMPRCs) for the purpose of solid-state deracemization has not been reported. Yet, forced periodic operation of reactors is not uncommon in the field of chemical engineering.…”
Section: Introductionmentioning
confidence: 99%
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“…The terms racemic conglomerate and racemic crystal are well established in the literature, but the corresponding terms for scalemic are much rarer, although not unknown. The first occurrence we could locate of scalemic conglomerate is in an article by Wei et al (2009), whereas scalemic crystal seems to have been used only recently (Neugebauer et al, 2021).…”
Section: Molecular Versus Structural Chiralitymentioning
confidence: 99%
“…Another, similar concept was presented in several publications, , where a small-diameter tube crystallizer which provided two inlets was employed, one for the solution from which the solute is to be crystallized and the other for either a gas or a liquid immiscible with the solution. This second fluid is used to segment the solution, generating defined droplets and providing control over the residence time distribution and particle size distribution. In addition, sonication was used to induce nucleation . The aim of this design was to provide a product with a uniform, narrow crystal size distribution.…”
Section: Introductionmentioning
confidence: 99%