1978
DOI: 10.1021/bi00602a024
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Complete covalent structure of human .beta.-thromboglobulin

Abstract: The complete primary structure of the platelet-specific protein human beta-thromboglobulin has been determined. beta-Thromboglobulin consists of identical subunits of 81 amino acids, each with a molecular weight of 8851. The amino acid sequence of the beta-thromboglobulin subunit is: Gly-Lys-Glu-Glu-Ser-Leu-Asp-Ser-Asp-Leu-Tyr-Ala-Glu-Leu-Arg-Cys-Met-Cys-Ile-Lys-Thr-Thr-Ser-Gly-Ile-His-Pro-Lys-Asn-Ile-Gln-Ser-Leu-Glu-Val-Ile-Gly-Lys-Gly-Thr-His-Cys-Asn-Gln-Val-Glu-Val-Ile-Ala-Thr-Leu-Lys-Asp-Gly-Arg-Lys-Ile-Cy… Show more

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Cited by 210 publications
(85 citation statements)
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“…The C termini of pCEF-4 and CTAP-III are 56% homologous when conserved residues are taken into account. Other related proteins such as ,B-thromboglobulin (19), platelet basic protein (a probable precursor of both CTAP-III and ,B-thromboglobulin, ref. 20), platelet factor 4 (16), and 'yIP-10, an interferon-inducible gene (21), also have homology with pCEF-4.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The C termini of pCEF-4 and CTAP-III are 56% homologous when conserved residues are taken into account. Other related proteins such as ,B-thromboglobulin (19), platelet basic protein (a probable precursor of both CTAP-III and ,B-thromboglobulin, ref. 20), platelet factor 4 (16), and 'yIP-10, an interferon-inducible gene (21), also have homology with pCEF-4.…”
Section: Resultsmentioning
confidence: 99%
“…The sequence of the pCEF-4 insert predicts a protein sequence homologous to CTAP-III and other biologically active peptides found in human platelets (16,(18)(19)(20). Although pleiotropic effects on cellular metabolism have been ascribed to this family of related polypeptides, including the stimulation of synthesis of DNA, glycosaminoglycan, hyaluronic acid as well as glycolysis, the significance of constitutive expression of pCEF4 in fibroblasts remains to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…21,22 Although many activities have been ascribed to PF-4, 1,4,23 a G protein-coupled receptor for this oldest CXC chemokine has still to be identified. In view of its high affinity for heparin, PF-4 was shown to activate neutrophils through binding to chondroitin sulfate-type glycosaminoglycans.…”
Section: Discussionmentioning
confidence: 99%
“…All inductions were done in the regular cell growth media. The IFN--y was always diluted into medium containing either 1 Positive phage were plaque purified, and DNA isolated from these phage was used for restriction analysis against human DNA. Northern (RNA blot) and Southern blot (hybridization) analyses.…”
Section: *Corresponding Authormentioning
confidence: 99%
“…The deduced amino acid sequence of the IP-10 protein reveals that it is a member of a newly emerging family of cytokines having chemotactic, mitogenic, and immunomodulatory activities. This family includes the platelet basic proteins (PBP) (e.g., ,B-thromboglobulin [1] and connective tissue-activating peptide III [7]), platelet factor 4 (PF4) (9), and two recently isolated cDNA clones designated 9E3 (36) and 310c (J. Schmid and C. Weissman, J. Immunol., in press).…”
mentioning
confidence: 99%