Complete Elimination of Peripheral Auditory Input Before Onset of Hearing Causes Long-Lasting Impaired Social Memory in Mice

Guo, Rui; Yang, Li; Liu, Jiao; Gong, Shusheng; Liu, Ke

doi:10.3389/fnins.2021.723658

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…The effect of SI on the basal activity of the HPA axis is controversial (Serra et al, 2005). The type, number, timing, and order of the behavioral tests conducted in previous studies differed from those used in this study (Benfato et al, 2022;Chang et al, 2015;Donovan et al, 2021;Guo et al, 2021), which might have contributed to these differences. Therefore, the protective effect of betaine treatment on the abnormal behavior and microglial function of SI mice might not be due to altered activity of the HPA axis.…”

Section: Discussionmentioning

confidence: 75%

Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice

Shi

Sun³

et al. 2023

Phytotherapy Research

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Chronic social isolation (SI) stress, which became more prevalent during the COVID‐19 pandemic, contributes to abnormal behavior, including mood changes and cognitive impairment. Known as a functional nutrient, betaine has potent antioxidant and anti‐inflammatory properties in vivo. However, whether betaine can alleviate the abnormal behavior induced by chronic SI in mice remains unknown. In this study, we investigated the efficacy of betaine in the treatment of behavioral changes and its underlying mechanism. Three‐week‐old male mice were randomly housed for 8 weeks in either group housing (GH) or SI. The animals were divided into normal saline‐treated GH, normal saline‐treated SI, and betaine‐treated SI groups in the sixth week. The cognitive and depression‐like behavior was determined in the eighth week. We found that long‐term betaine administration improved cognitive behavior in SI mice but failed to prevent depression‐like behavior. Moreover, long‐term betaine administration inhibited hippocampal microglia over‐activation and polarized microglia toward the M2 phenotype, which effectively inhibited the expression of inflammatory factors in SI mice. Finally, the protective effect of betaine treatment in SI mice might not be due to altered activity of the hypothalamic–pituitary–adrenal axis. Collectively, our findings reveal that betaine can improve SI‐induced cognitive impairment, thus providing an alternative natural source for the prevention of memory loss caused by SI or loneliness.

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Section: Discussionmentioning

confidence: 75%

Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice

Shi

Sun³

et al. 2023

Phytotherapy Research

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“…Additionally, GABAa and GABAb receptors were altered during this time period. The change in these neurotransmitter receptors is implicated in hippocampal synaptic plasticity, affecting hippocampal learning, and resulting in cognitive decline (Guo et al, 2021 ).…”

Section: Mechanisms Underlying Hearing Loss Cognitive Function and Ad...mentioning

confidence: 99%

Hearing loss and its link to cognitive impairment and dementia

Azeem,

Julleekeea,

Knight

et al. 2023

Front. Dement.

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Hearing loss is an important risk factor for the development of dementia, particularly Alzheimer's disease (AD). Mid-life hearing loss increases the risk of developing dementia by double any other single factor. However, given this strong connection between hearing loss and AD, the mechanisms responsible for this link are still unknown. Data from observational studies relating hearing loss and cognitive impairment, measured with standardized questionnaires, has shown a strong relationship between them. Similar findings have emerged from animal studies, showing that the induction of hearing loss via prolonged loud sound exposure or ear canal blocking, can impair cognitive abilities. Interestingly, patients with age-related hearing impairment exhibit increased phosphorylated tau in the cerebrospinal fluid, but no such relationship has been identified for amyloid-β. In addition, hearing loss predisposes to social isolation precipitating the development of dementia through a supposed reduction in cognitive load and processing requirements. Given this link between hearing loss and dementia, the question arises whether the restoration of hearing might mitigate against the onset or progress of AD. Indeed, there is a growing body of research that suggests that those who wear hearing aids for age-related hearing problems maintain better cognitive function over time than those who do not. These are compelling findings, as they suggest the use of hearing aids has the potential to be a cost-effective treatment for those with hearing loss both prior (for those at high risk for AD) and after the development of symptoms. This review aims to summarize the current theories that relate hearing loss and cognitive decline, present the key findings of animal studies, observational studies and summarize the gaps and limitations that need to be addressed in this topic. Through this, we suggest directions for future studies to tackle the lack of adequately randomized control trials in the field. This omission is responsible for the inability to provide a conclusive verdict on whether to use hearing interventions to target hearing-loss related cognitive decline.

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Noise-induced hearing loss reduces inhibitory neurotransmitter synthesis in ventral hippocampus and contributes to the social memory deficits of mice

Qianru,

Teng,

et al. 2024

Neuroscience Letters

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Complete Elimination of Peripheral Auditory Input Before Onset of Hearing Causes Long-Lasting Impaired Social Memory in Mice

Cited by 3 publications

References 36 publications

Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice

Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice

Hearing loss and its link to cognitive impairment and dementia

Noise-induced hearing loss reduces inhibitory neurotransmitter synthesis in ventral hippocampus and contributes to the social memory deficits of mice

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