Complete genome sequence and phylogenetic analysis of nosocomial pathogen Acinetobacter nosocomialis strain NCTC 8102

Subhadra, Bindu; Surendran, Surya; Lim, Bo Ra; Yim, Jong-Sung; Kim, Dong Ho; Woo, Kyungho; Han, Kyudong; Oh, Man Hwan; Choi, Chul Hee

doi:10.1007/s13258-019-00834-6

Cited by 7 publications

(1 citation statement)

References 35 publications

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“…Acinetobacter baumannii and its close relative Acinetobacter nosocomialis have one quorum sensing (QS) system, which plays an integral role in regulating virulence factors, biofilm formation and surface motility (Niu et al, 2008;Clemmer et al, 2011;Bhargava et al, 2015;Subhadra et al, 2019). AbaI is the autoinducer synthase that generates the QS molecule N-(3-hydroxydodecanoyl)-L-HSL (AHL), which at high enough density interacts with the cognate receptor AbaR leading to downstream cellular responses.…”

Section: Biofilm Formation Cues and Detectionmentioning

confidence: 99%

Insights Into Mechanisms of Biofilm Formation in Acinetobacter baumannii and Implications for Uropathogenesis

Colquhoun

Rather

2020

Front. Cell. Infect. Microbiol.

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Multidrug resistant Acinetobacter baumannii is a serious healthcare threat. In fact, the Center for Disease Control recently reported that carbapenem-resistant A. baumannii is responsible for more than 8,500 infections, 700 deaths, and $281 million in healthcare costs annually in the United States with few, if any, treatment options available, leading to its designation as a pathogen of urgent concern and a priority for novel antimicrobial development. It is hypothesized that biofilms are, at least in part, responsible for the high prevalence of A. baumannii nosocomial and recurrent infections because they frequently contaminate hospital surfaces and patient indwelling devices; therefore, there has been a recent push for mechanistic understanding of biofilm formation, maturation and dispersal. However, most research has focused on A. baumannii pneumonia and bloodstream infections, despite a recent retrospective study showing that 17.1% of A. baumannii isolates compiled from clinical studies over the last two decades were obtained from urinary samples. This highlights that A. baumannii is an underappreciated uropathogen. The following minireview will examine our current understanding of A. baumannii biofilm formation and how this influences urinary tract colonization and pathogenesis.

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Section: Biofilm Formation Cues and Detectionmentioning

confidence: 99%