Complete Genome Sequence of Duck Tembusu Virus, Isolated from Muscovy Ducks in Southern China

Zhu, Wanjun; Chen, Jidang; Wei, Chunya; Wang, Heng; Huang, Zhen; Zhang, Minze; Tang, Fengfeng; Xie, Jiexiong; Liang, Hui; Zhang, Guihong; Su, Shuo

doi:10.1128/jvi.02361-12

Cited by 25 publications

(16 citation statements)

References 4 publications

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“…The genomic RNA of flaviviruses is infectious and has a positive polarity with regard to the coding regions of all viral proteins [15]. NCRs of different lengths [a 5¢ NCR from 67 (DENV) to 132 (tickborne encephalitis virus, TBEV) bases and a 3¢ NCR from 114 (TBEV) to 585 (JEV) bases] flank the long ORF in different Flaviviridae species [16][17][18][19][20][21]. Through subsequent cleavage by viral and cellular proteases, the polyprotein is processed into three structural proteins from the 5¢ end of the genome [i.e.…”

Section: Viral Genome Characteristicsmentioning

confidence: 99%

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

Zhang

Chen

Mahalingam

et al. 2017

Journal of General Virology

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Tembusu virus (TMUV, genus Flavivirus, family Flaviviridae) was first isolated in 1955 from Culex tritaeniorhynchus mosquitoes in Kuala Lumpur, Malaysia. In April 2010, duck TMUV was first identified as the causative agent of egg-drop syndrome, characterized by a substantial decrease in egg laying and depression, growth retardation and neurological signs or death in infected egg-laying and breeder ducks, in the People's Republic of China. Since 2010, duck TMUV has spread to most of the duck-producing regions in China, including many of the coastal provinces, neighbouring regions and certain Southeast Asia areas (i.e. Thailand and Malaysia). This review describes the current understanding of the genome characteristics, host range, transmission, epidemiology, phylogenetic and immune evasion of avian-origin TMUV and the innate immune response of the host.

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Section: Viral Genome Characteristicsmentioning

confidence: 99%

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

Zhang

Chen

Mahalingam

et al. 2017

Journal of General Virology

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“…We and other colleagues have identified TMUV as the causative agent of the disease (Cao et al, 2011;Su et al, 2011;Yan et al, 2011). Although it was first isolated from ducks during the 2010 outbreak, TMUV has now been routinely isolated from ducks, geese, chickens, pigeons, sparrows, and mosquitos, suggesting TUMV has a wide host range (Chen et al, 2013(Chen et al, , 2014Han et al, 2013;Huang et al, 2012;Liu et al, 2012;Tang et al, 2012Tang et al, , 2013aWan et al, 2012;Xie et al, 2014;Yu et al, 2013;Yun et al, 2012a,b;Zhu et al, 2012). Recently, it has been indicated that TMUV causes neurovirulence in mice and mortality ranging from 20% to 80% when intracerebrally inoculated with a dose of 7.5 Â 10 4 PFU/mouse .…”

Section: Introductionmentioning

confidence: 95%

Evolutionary analysis of Tembusu virus: Evidence for the emergence of a dominant genotype

Dai

2015

Infection, Genetics and Evolution

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“…In addition to the DEDSV infection in adult laying ducks, the causative pathogen has been isolated from young meat-type ducks, geese, house sparrows, and a dead racing pigeon [16,20,21,25,27]. The virus-infected ducklings and geese display various degrees of neurological signs, ranging from recumbency to leg and wing paralysis.…”

Section: Clinical and Pathological Datamentioning

confidence: 99%

Duck egg drop syndrome virus: an emerging Tembusu-related flavivirus in China

Lü

et al. 2013

Sci. China Life Sci.

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Duck egg drop syndrome virus (DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China. DEDSV infection mainly results in severe egg drop syndrome in domestic poultry, which leads to huge economic losses. Thus, the discovery of ways and means to combat DEDSV is urgent. Since 2010, a remarkable amount of progress concerning DEDSV research has been achieved. Here, we review current knowledge on the epidemiology, symptomatology, and pathology of DEDSV. A detailed dissection of the viral genome and polyprotein sequences, comparative analysis of viral antigenicity and the corresponding potential immunity against the virus are also summarized. Current findings indicate that DEDSV should be a distinct species from Tembusu virus. Moreover, the adaption of DEDSV in wildlife and its high homology to pathogenic flaviviruses (e.g., West Nile virus, Japanese encephalitis virus, and dengue virus), illustrate its reemergence and potential to become a zoonotic pathogen that should not be overlooked. Detailed insight into the antigenicity and corresponding immunity against the virus is of clear significance for the development of vaccines and antiviral drugs specific for DEDSV.

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Complete Genome Sequence of Duck Tembusu Virus, Isolated from Muscovy Ducks in Southern China

Cited by 25 publications

References 4 publications

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

Evolutionary analysis of Tembusu virus: Evidence for the emergence of a dominant genotype

Duck egg drop syndrome virus: an emerging Tembusu-related flavivirus in China

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