Complete Genome Sequences, Derived by Next-Generation Sequencing, of JC Polyomavirus Strains Isolated from Vietnamese Renal Transplant Recipients

Van, Trang Dinh; Rockett, Rebecca; Ha, An Phan Hai; Nguyen, Trung Vu; Dwyer, Dominic E.

doi:10.1128/mra.01350-19

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“…This result was similar to other studies that reported JCV subtype 7A was found in Asian populations 9,19 . To our knowledge, there were only a few reports that identified JCV subtype 7A and 7B1 in Vietnamese patients 20,21 but JCV subtype 7C1 was for the first time observed in this study. It was also proposed that the identification of JCV genotypes can be used for tracing the migration and evolution of JCV 22 .…”

Section: Discussionsupporting

confidence: 92%

Prevalence and genotype distribution of JC polyomavirus in urine from patients with hematological malignancies in Vietnam

Bang

Xuan

Trung

et al. 2021

Journal of Medical Virology

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JC virus (JCV) causes progressive multifocal leukoencephalopathy in immunocompromised patients. The prevalence and genotype patterns of JCV vary between different geographical regions. This study was done to investigate the prevalence and genotype distribution of JCV in patients with hematological malignancies in Vietnam. A total of 48 urine samples were collected from patients with hematological malignancies. DNA was extracted and detection of JCV was by nested‐polymerase chain reaction. Sequence analysis was obtained and a phylogenetic tree was constructed for genotyping of JCV. Twenty‐seven (56.25%) urine samples tested positive for JCV. JCV genotype 7 was only observed in this study. Subtype analysis showed that JCV subtype 7A was the most commonly prevalent, followed by 7B1 and 7C1. Other subtypes were not detected in this population. There were no significant differences associated with age, gender, and biochemical parameters between patients with JCV and without JCV excretion in urine. The present study showed a high prevalence of JCV in the urine of patients with hematologic malignancies. The most common genotype found in this population was JCV subtype 7A.

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Section: Discussionsupporting

confidence: 92%