Complete Genome Sequences of Mycoplasma ovipneumoniae Strains 150 and 274, Isolated from Different Regions in Bosnia and Herzegovina

Hao, Hiroyuki; Maksimović, Zinka; Ma, Lu; Rifatbegović, Maid; Chen, Shengli; Yan, Xingcheng; Fu, Lei; Chu, Yuefeng

doi:10.1128/mra.00011-23

Cited by 1 publication

(1 citation statement)

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“…In accordance with expectations, our strain NXNK2203, isolated from Hu sheep, fell within the clade associated with sheep hosts. Furthermore, the evolutionary analysis indicated that M. ovipneumoniae strain NXNK2203 exhibited the closest evolutionary relationship with the NM2010 strain (isolated from Inner Mongolia, China) and the 150 strain (isolated from Central Bosnia Canton) [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring Mycoplasma ovipneumoniae NXNK2203 infection in sheep: insights from histopathology and whole genome sequencing

Wang,

Liu,

Raheem

et al. 2024

BMC Vet Res

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Background Mycoplasma ovipneumoniae (M. ovipneumoniae) is a significant pathogen causing respiratory infections in goats and sheep. This study focuses on investigating vulnerability of Hu sheep to M. ovipneumoniae infection in the context of late spring’s cold weather conditions through detailed autopsy of a severely affected Hu sheep and whole genome sequencing of M. ovipneumoniae. Results The autopsy findings of the deceased sheep revealed severe pulmonary damage with concentrated tracheal and lung lesions. Histopathological analysis showed tissue degeneration, mucus accumulation, alveolar septum thickening, and cellular necrosis. Immunohistochemistry analysis indicated that M. ovipneumoniae was more in the bronchi compared to the trachea. Genome analysis of M. ovipneumoniae identified a 1,014,835 bp with 686 coding sequences, 3 rRNAs, 30 tRNAs, 6 CRISPRs, 11 genomic islands, 4 prophages, 73 virulence factors, and 20 secreted proteins. Conclusion This study investigates the vulnerability of Hu sheep to M. ovipneumoniae infection during late spring’s cold weather conditions. Autopsy findings showed severe pulmonary injury in affected sheep, and whole genome sequencing identified genetic elements associated with pathogenicity and virulence factors of M. ovipneumoniae.

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Section: Resultsmentioning

confidence: 99%