Complete mitochondrial genome of the gray mouse lemur,
            <i>Microcebus murinus</i>
            (Primates, Cheirogaleidae)

Lecompte, Émilie; Crouau‐Roy, Brigitte; Aujard, Fabienne; Holota, Hélène; Murienne, Jérôme

doi:10.3109/19401736.2015.1074196

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…Sequences were aligned to the M. sp. #3 nuclear genome generated by this study, and to the published M. murinus mitochondrial genome (LeCompte et al 2016). We used two genotyping approaches to ensure robustness of our results.…”

Section: Sequencing Data Genotyping and Genome Assemblymentioning

confidence: 99%

Cryptic Patterns of Speciation in Cryptic Primates: Microendemic Mouse Lemurs and the Multispecies Coalescent

et al. 2020

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Abstract Mouse lemurs (Microcebus) are a radiation of morphologically cryptic primates distributed throughout Madagascar for which the number of recognized species has exploded in the past two decades. This taxonomic revision has prompted understandable concern that there has been substantial oversplitting in the mouse lemur clade. Here, we investigate mouse lemur diversity in a region in northeastern Madagascar with high levels of microendemism and predicted habitat loss. We analyzed RADseq data with multispecies coalescent (MSC) species delimitation methods for two pairs of sister lineages that include three named species and an undescribed lineage previously identified to have divergent mtDNA. Marked differences in effective population sizes, levels of gene flow, patterns of isolation-by-distance, and species delimitation results were found among the two pairs of lineages. Whereas all tests support the recognition of the presently undescribed lineage as a separate species, the species-level distinction of two previously described species, M. mittermeieri and M. lehilahytsara is not supported – a result that is particularly striking when using the genealogical discordance index (gdi). Non-sister lineages occur sympatrically in two of the localities sampled for this study, despite an estimated divergence time of less than 1 Ma. This suggests rapid evolution of reproductive isolation in the focal lineages, and in the mouse lemur clade generally. The divergence time estimates reported here are based on the MSC calibrated with pedigree-based mutation rates and are considerably more recent than previously published fossil-calibrated relaxed-clock estimates. We discuss the possible explanations for this discrepancy, noting that there are theoretical justifications for preferring the MSC estimates in this case.

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Section: Sequencing Data Genotyping and Genome Assemblymentioning

confidence: 99%

Cryptic Patterns of Speciation in Cryptic Primates: Microendemic Mouse Lemurs and the Multispecies Coalescent

et al. 2020

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“…In addition to the above-mentioned assembly for H. griseus , we mined data from publicly available genome assemblies for 14 species: Prolemur simus (Hawkins et al, 2018), Lemur catta (Palmada-Flores et al, 2022), Eulemur flavifrons and E. macaco (Meyer et al 2015), Propithecus coquereli (Lowe and Eddy 1997; Guevara et al 2021), Indri indri (accession number: GCA_004363605.1), Daubentonia madagascariensis (accession number: GCA_004027145.1), Mirza coquereli (accession number: GCA_004024645.1), Mirza zaza (Hunnicutt et al, 2020), and Microcebus murinus (Averdam et al, 2011; Lecompte et al, 2016), as well as the following additional species of mouse lemur: Mic. griseorufus, Mic.…”

Section: Methodsmentioning

confidence: 99%

Hyper-specialized primates possess a reduced suite of xenobiotic-metabolizing cytochrome P450 genes

Chaney,

Tosi,

Bergey

2023

Preprint

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Subfamilies of cytochrome P450 proteins have been strongly linked to the metabolism of physiologically disruptive compounds such as alkaloids, terpenoids, and other xenobiotics. Consistent with this function, these genes have adaptively evolved in response to environmental pressures exerted on animals, such as herbivores, that consume elevated amounts of toxic xenobiotics or plant secondary metabolites (PSMs). Theory on evolutionary tradeoffs predicts that highly specialized herbivores should exhibit a relatively narrow toolkit of adaptations to accommodate the concomitantly narrow arrays of PSMs in their diets. The bamboo lemurs of Madagascar (genera Prolemur and Hapalemur) represent an interesting test case for this theory because of their dietary hyper-specialization, as these lemurs consume bamboo and grasses at rates otherwise unseen in the order Primates. To test whether the hyper-specialized folivory of these primates is reflected in a similarly specialized and narrow P450 gene suite, we assembled a dataset of confidently assembled CYP1-3 genes for two species of bamboo lemur and 13 additional lemur species. With this dataset, we tested the predictions that bamboo lemurs would exhibit, first, greater rates of gene loss for xenobiotic-metabolizing P450s and, second, relaxed selection on xenobiotic-metabolizing P450 subfamilies relative to lemurs without such dietary hyper-specialization. We found support for the prediction of gene loss in the CYP2B, CYP2C, CYP2D, CYP2J, and CYP3A subfamilies, all of which encode xenobiotic metabolizers. We inferred relaxation of selection for the CYP1A and CYP2D subfamilies. The CYP2F subfamily exhibited a signal of significant intensification of selection in the bamboo-lemur lineage. The evolution of the P450 genes in bamboo lemurs provides support for the evolutionary tradeoff hypothesis, and we further hypothesize that, rather than adapting to a general array of PSMs, bamboo lemurs have instead adapted to the primary toxin in their diet, the highly potent poison cyanide.

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“…Subsequent work was then conducted to address the impact of PUFA supplementation on brain glucose utilization with protocols involving both human and non-human primates, particularly the grey mouse lemur (Microcebus murinus), an emerging and promising animal model in the fields of neuroscience and ageing [31][32][33]. In addition to sharing closer phylogenetic proximity to humans than rodents [31,34], the grey mouse lemur also shares several neuroanatomical traits with higher primates, including humans [35,36], and has the advantage of being a true omnivorous species [37], which is of major interest in applied nutrition studies. In 2015, our group described the positive effect of long-chain n-3 PUFAs from fish oil on mouse lemur brain glucose utilization using PET 18F-FDG [38].…”

Section: Positron Emission Tomography Studiesmentioning

confidence: 99%

Evidence of the Role of Omega-3 Polyunsaturated Fatty Acids in Brain Glucose Metabolism

Pifferi

Cunnane

Guesnet³

2020

Nutrients

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In mammals, brain function, particularly neuronal activity, has high energy needs. When glucose is supplemented by alternative oxidative substrates under different physiological conditions, these fuels do not fully replace the functions fulfilled by glucose. Thus, it is of major importance that the brain is almost continuously supplied with glucose from the circulation. Numerous studies describe the decrease in brain glucose metabolism during healthy or pathological ageing, but little is known about the mechanisms that cause such impairment. Although it appears difficult to determine the exact role of brain glucose hypometabolism during healthy ageing or during age-related neurodegenerative diseases such as Alzheimer’s disease, uninterrupted glucose supply to the brain is still of major importance for proper brain function. Interestingly, a body of evidence suggests that dietary n-3 polyunsaturated fatty acids (PUFAs) might play significant roles in brain glucose regulation. Thus, the goal of the present review is to summarize this evidence and address the role of n-3 PUFAs in brain energy metabolism. Taken together, these data suggest that ensuring an adequate dietary supply of n-3 PUFAs could constitute an essential aspect of a promising strategy to promote optimal brain function during both healthy and pathological ageing.

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Complete mitochondrial genome of the gray mouse lemur, Microcebus murinus (Primates, Cheirogaleidae)

Cited by 4 publications

References 11 publications

Cryptic Patterns of Speciation in Cryptic Primates: Microendemic Mouse Lemurs and the Multispecies Coalescent

Cryptic Patterns of Speciation in Cryptic Primates: Microendemic Mouse Lemurs and the Multispecies Coalescent

Hyper-specialized primates possess a reduced suite of xenobiotic-metabolizing cytochrome P450 genes

Evidence of the Role of Omega-3 Polyunsaturated Fatty Acids in Brain Glucose Metabolism

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