Complete mtDNA genomes of Filipino ethnolinguistic groups: a melting pot of recent and ancient lineages in the Asia-Pacific region

Delfin, Frederick C.; Ko, Albert Min-Shan; Li, Mingkun; Gunnarsdóttir, Ellen; Tabbada, Kristina A.; Salvador, Jazelyn M.; Calacal, Gayvelline C.; Sagum, Minerva S.; Datar, Francisco A.; Padilla, Sabino G.; Ungria, Maria Corazon A. De; Stoneking, Mark

doi:10.1038/ejhg.2013.122

Cited by 54 publications

(49 citation statements)

References 35 publications

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“…Haplogroup N11 presents the oldest divergence (around 76 kya) with two main branches, N11a and N11b. N11a is spread in central, western China and Inner Mongolia, and also in southern China and in Makatao from Taiwan [ 39 – 42 ], whereas N11b is found in Philippines [ 43 , 44 ].The second most ancient lineage is N10 (around 66 kya) being mainly detected in southern China, the Tibet and in Lingao from Hainan [ 39 , 45 ]. It is relevant to mention here that, albeit in a smaller proportion, Tibetan and Southeastern Asians, like Filipinos, have introgressed Denisovan-like DNA in their genomes [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Carriers of Mitochondrial DNA Macrohaplogroup N Lineages Reached Australia around 50,000 Years Ago following a Northern Asian Route

Fregel¹,

Cabrera²,

Larruga³

et al. 2015

PLoS ONE

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BackgroundThe modern human colonization of Eurasia and Australia is mostly explained by a single-out-of-Africa exit following a southern coastal route throughout Arabia and India. However, dispersal across the Levant would better explain the introgression with Neanderthals, and more than one exit would fit better with the different ancient genomic components discovered in indigenous Australians and in ancient Europeans. The existence of an additional Northern route used by modern humans to reach Australia was previously deduced from the phylogeography of mtDNA macrohaplogroup N. Here, we present new mtDNA data and new multidisciplinary information that add more support to this northern route.MethodsMtDNA hypervariable segments and haplogroup diagnostic coding positions were analyzed in 2,278 Saudi Arabs, from which 1,725 are new samples. Besides, we used 623 published mtDNA genomes belonging to macrohaplogroup N, but not R, to build updated phylogenetic trees to calculate their coalescence ages, and more than 70,000 partial mtDNA sequences were screened to establish their respective geographic ranges.ResultsThe Saudi mtDNA profile confirms the absence of autochthonous mtDNA lineages in Arabia with coalescence ages deep enough to support population continuity in the region since the out-of-Africa episode. In contrast to Australia, where N(xR) haplogroups are found in high frequency and with deep coalescence ages, there are not autochthonous N(xR) lineages in India nor N(xR) branches with coalescence ages as deep as those found in Australia. These patterns are at odds with the supposition that Australian colonizers harboring N(xR) lineages used a route involving India as a stage. The most ancient N(xR) lineages in Eurasia are found in China, and inconsistently with the coastal route, N(xR) haplogroups with the southernmost geographical range have all more recent radiations than the Australians.ConclusionsApart from a single migration event via a southern route, phylogeny and phylogeography of N(xR) lineages support that people carrying mtDNA N lineages could have reach Australia following a northern route through Asia. Data from other disciplines also support this scenario.

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Section: Resultsmentioning

confidence: 99%

Carriers of Mitochondrial DNA Macrohaplogroup N Lineages Reached Australia around 50,000 Years Ago following a Northern Asian Route

Fregel¹,

Cabrera²,

Larruga³

et al. 2015

PLoS ONE

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“…8 The SEA negritos are of interest because they are characterized by basal genetic lineages that likely reflect the earliest dispersal of modern humans from Africa 6,34 . However, there is also evidence that at least some negrito groups have interacted and mixed with non-negrito groups [10][11][12]35 . Among the three basal mtDNA haplogroups (M21a, M17a and R21) observed in the Maniq (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Several genetic studies have been conducted in some of these relic populations and indicated deep ancestry [6][7][8][9][10][11][12][13] which could link these people with the ancestral groups who migrated from Africa into SEA during the late Pleistocene 14 . However, the hunter-gatherer groups of Thailand are relatively under-studied compared to those from other SEA regions.…”

Section: Introductionmentioning

confidence: 99%

Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand

Kutanan

Kampuansai

Changmai

et al. 2017

Preprint

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The Maniq and Mlabri are the only recorded nomadic hunter-gatherer groups in Thailand.Here, we sequenced complete mitochondrial (mt) DNA genomes and ~2.364 Mbp of nonrecombining Y chromosome (NRY) to learn more about the origins of these two enigmatic populations. Both groups exhibited low genetic diversity compared to other Thai populations, and contrasting patterns of mtDNA and NRY diversity: there was greater mtDNA diversity in the Maniq than in the Mlabri, while the converse was true for the NRY. We found basal uniparental lineages in the Maniq, namely mtDNA haplogroups M21a, R21 and M17a, and NRY haplogroup

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“…Recent developments in sequencing technology allow the determination of complete mtDNA genomes at the population level and thus enable unbiased insights into the maternal history of human populations (Delfin et al, ; Gunnarsdottir, Li, Bauchet, Finstermeier, & Stoneking, ; Kivisild, ). At present, no such studies are reported for South American indigenous populations.…”

Section: Introductionmentioning

confidence: 99%

High‐resolution mitochondrial DNA analysis sheds light on human diversity, cultural interactions, and population mobility in Northwestern Amazonia

Arias

Barbieri

Barreto

et al. 2017

American J Phys Anthropol

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Contrary to the view of NWA as a pristine area inhabited by small human populations living in isolation, our data support a view of high diversity and contact among different ethnolinguistic groups, with movement along rivers probably facilitating this contact. Additionally, we provide evidence for the impact of cultural practices, such as linguistic exogamy, on patterns of genetic variation. Overall, this study provides new data and insights into a remote and little-studied region of the world.

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Complete mtDNA genomes of Filipino ethnolinguistic groups: a melting pot of recent and ancient lineages in the Asia-Pacific region

Cited by 54 publications

References 35 publications

Carriers of Mitochondrial DNA Macrohaplogroup N Lineages Reached Australia around 50,000 Years Ago following a Northern Asian Route

Carriers of Mitochondrial DNA Macrohaplogroup N Lineages Reached Australia around 50,000 Years Ago following a Northern Asian Route

Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand

High‐resolution mitochondrial DNA analysis sheds light on human diversity, cultural interactions, and population mobility in Northwestern Amazonia

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