T horacic surgery has undergone many changes. Lung resection was not performed to any significant degree until less than 100 years ago. Initially, surgery for complications of tuberculosis predominated. It is often said that tuberculosis allowed the field of thoracic surgery to evolve. However, considering how difficult surgery is for end-stage tuberculosis, even in the modern era, perhaps, it was the appearance of lung cancer, and thus patients with less chronically scarred chest anatomy, that allowed the specialty to develop. Initial resection involved pneumonectomy, but gradually, the anatomy began to be understood better, and lobectomy became the most common operation. More recently, the approach has changed, at least in experienced centers, so that most lobectomies are performed by a minimally invasive video-assisted thoracic surgery approach (VATS). The use of robotic technology, with enhanced articulation of instruments, is beginning to be explored. Although these advances are associated with a learning curve and require validation to define their appropriate place, there is no doubt that thoracic surgery is a dynamic field that continues to evolve. Given this history and current state of affairs, what does the future hold? This article explores potential new developments in thoracic surgery. THE FORCES OF CHANGE What are the forces that are bringing about change? There is no doubt that surgery is invasive. In fact, this is a strength of surgery: to directly approach a problem (altered anatomy) and to fix it. Although advances are likely that will prevent problems from developing, halt their progression, or perhaps minimize the consequences, anatomic problems will likely always require a direct approach. At the same time, the invasive nature of surgery is a limitation. A less invasive approach to an anatomic site is at least conceptually desirable. This includes smaller incisions, VATS, or catheter-based approaches. Of course, it must be demonstrated that such less invasive approaches provide an effective and safe way of addressing the problem at hand. But incisions are associated with pain, and pain is a strong motivator for patients. Therefore, the push toward less invasive approaches is enormous, sometimes even overshadowing the desire for treatment efficacy. Other changes in the world we live in are important. Technology is advancing at a rapid, accelerating pace, providing new opportunities to explore alternative approaches. For example, advances in imaging technology, always a critical aspect for surgical procedures, have been crucial to the development of VATS approaches. On a different level, imaging is changing the very nature of the diseases we encounter; increased computed tomography imaging results in a shift to more early-stage lung cancer, 1 as well as an increased proportion of more slow-growing cancers. 2 Less extensive resection may be appropriate for many such lesions, although the role of such interventions is still being defined. Advances in clinical science, data gathering, and analysi...